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Electrochemical sensor for selective detection of norepinephrine using graphene sheets-gold nanoparticle complex modified electrode

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Abstract

Neural diseases, like Alzheimer’s (AD) and Parkinson’s (PD) are widely expanding portions of neurodegenerative diseases, are related to norepinephrine (NE) concentration with proportional correlation. However, quantification of NE is quite difficult because NE coexists with ascorbic acid (AA) and uric acid (UA), which interferes with detecting NE in biological fluid. We fabricated a multi-modified electrode with reduced graphene oxide sheets (GS) and gold nanoparticles (GNPs) for highly selective and sensitive detection of NE. Thus, GS-GNPs modified electrode could enhance the sensitivity for detection of NE, as well as highly sensitive manner with AA. Compared with recent studies, our newly developed sensor appears to have not only a wide detection range (0.2-10 μM), but also superior detection limit (200 nM) in presence of 2000 times higher concentration of AA.

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Authors and Affiliations

  1. Department of Chemical & Biomolecular Engineering, Sogang University, Seoul, 04107, Korea

    Eun Jung Lee, Jin-Ha Choi & Byung-Keun Oh

  2. School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Korea

    Soong Ho Um

Authors
  1. Eun Jung Lee
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  2. Jin-Ha Choi
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  3. Soong Ho Um
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  4. Byung-Keun Oh
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Corresponding author

Correspondence to Byung-Keun Oh.

Additional information

This article is dedicated to Prof. Ki-Pung Yoo on the occasion of his retirement from Sogang University.

The authors contributed equally in this work.

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Lee, E.J., Choi, JH., Um, S.H. et al. Electrochemical sensor for selective detection of norepinephrine using graphene sheets-gold nanoparticle complex modified electrode. Korean J. Chem. Eng. 34, 1129–1132 (2017). https://doi.org/10.1007/s11814-016-0363-4

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  • DOI: https://doi.org/10.1007/s11814-016-0363-4

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