Skip to main content
SpringerLink
Log in

Antihyperglycemic and antioxidant activities of polysaccharide produced from Pleurotus ferulae in streptozotocin-induced diabetic rats

  • Biotechnology
  • Published:
Korean Journal of Chemical Engineering Aims and scope Submit manuscript

Abstract

We investigated the antihyperglycemic and antioxidant activities of polysaccharides produced from Pleurotus ferulae mutant in streptozotocin-induced diabetic rats. Blood glucose level in the STZ-induced diabetic rat administered the extract polysaccharides, 250mg/kg b·w/d (EPSG) was 196.97mg/dL, approximately 54.12% less compared to that of the STZ-induced diabetic rats administered 0.9% NaCl solution (NCG). The insulin level in the EPSG was approximately 1.64-fold higher than that in the NCG. HDL and LDL cholesterol levels in the EPSG were 29.15mg/L and 20.35mg/dL, respectively, representing an approximate increase of 69.18% and decrease of 38.52%, respectively. The activities of aspartate aminotransferase (AST) and alanine transferase (ALT) in the EPSG decreased approximately by 49.27 and 50.43%, respectively, while the alkaline phosphatase (ALP) activity decreased by 34.25%, relative to the NCG. Antioxidant activities in the NCG decreased relative to the normal group. In contrast, for EPSG, these values increased relative to the NCG. The malondialdehyde level in the EPSG was 12.95mmol/mg protein, which was approximately 70.64% of that in the NCG. These results suggest that the polysaccharides of Pleurotus ferulae mutant could be developed as potential antidiabetic agents or functional foods for people with a high risk of diabetes mellitus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. Gordon, Nat. Product Rep., 13, 265 (1996).

    Article  CAS  Google Scholar 

  2. S. Wild, M. B. Bchir, G. Roglic, A. Green, R. Sicree and H. King, Diabetes Care, 27, 1047 (2004).

    Article  Google Scholar 

  3. N. Sharma, V. Garg and A. Paul, Indian J. Clin. Biochem., 25, 193 (2010).

    Article  CAS  Google Scholar 

  4. M. A. Atkinson and N. K. Maclaren, New Engl. J. Med., 331, 1428 (1994).

    Article  CAS  Google Scholar 

  5. H. Yki-Jarvinen, Lancet., 343, 91 (1994).

    Article  CAS  Google Scholar 

  6. A. Mehmet and K. Sevda, Eur. J. Biosci., 3, 58 (2009).

    Google Scholar 

  7. K. Y. Hong, B. Y. Kim and H. K. Kim, Kor. J. Food Sci. Technol., 36, 563 (2004).

    Google Scholar 

  8. J. Y. Rho and S. D. Park, J. Microbio., 49, 191 (2013).

    Google Scholar 

  9. D. B. Choi, S. H. Kang, Y. H. Song, K. H. Kwun, K. J. Jeong and W. S. Cha, J. Microbiol. Biotechnol., 15, 368 (2005).

    CAS  Google Scholar 

  10. D. B. Choi, W. S. Cha and S. H. Kang, Biotechnol. Biopro. Eng., 9, 356 (2004).

    Article  CAS  Google Scholar 

  11. B. H. Kim, D. B. Choi, Y. L. Piao, S. S. Park, M. K. Lee, W. S. Cha, Y. C. Chang and H. Cho., Korean J. Chem. Eng., 29, 1393 (2012).

    Article  CAS  Google Scholar 

  12. T. C. Lo, C. A. Chang, K. Chiuc, P. K. Tsayd and J. F. Jena, Carbohydrate Poly., 86, 320 (2011).

    Article  CAS  Google Scholar 

  13. S. I. Lee, J. S. Kim, S. H. Oh, K. Y. Park, H. G. Lee and S. D. Kim, J. Med. Food, 11, 518 (2008).

    Article  CAS  Google Scholar 

  14. V. K. Murthy, J. C. Shipp, C. Hanson and D. M. Shipp, Diabetes Res. Clini. Practice, 18, 11 (1992).

    Article  CAS  Google Scholar 

  15. X. Hu, P. H. Yin, L. Zhao and Q. M. Yu, Biotechnol. Biopro. Eng., 20, 58 (2015).

    Article  CAS  Google Scholar 

  16. J. D. Hayes and L. I. McLellan, Free Radical Res., 31, 273 (1999).

    Article  CAS  Google Scholar 

  17. S. Ali, G. Diwakar, S. Pawa, M. R. Siddiqui, M. Z. Abdin, F. J. Ahmad and S. K. Jain, Biochem. Biophys. Acta., 1536, 21 (2001).

    CAS  Google Scholar 

  18. H. J. Hwang, S. W. Kim, J. M. Lim, J. H. Joo, H. O. Kim, H. M. Kim and J. W. Yun, Life Sci., 76, 3069 (2005).

    Article  CAS  Google Scholar 

  19. H. S. Hwang and J. W. Yun, Biotech. Biopro. Eng., 15, 173 (2010).

    Article  CAS  Google Scholar 

  20. C. X. Xio, Q. P. Wu, W. Cai, J. B. Tan, X. B. Yang and J. M. Jhang, Arch. Pharm. Res., 35, 1793 (2012).

    Article  Google Scholar 

  21. M. Y. Kim, M. H. Park and G. H. Kim, J. Kor. Nutr., 30, 743 (1997).

    Google Scholar 

  22. Z. Yuan, P. He, J. Cui and H. Takeuchi, Bisci. Biotech. Biochem., 62, 1898 (1998).

    Article  CAS  Google Scholar 

  23. H. R. Park and J. S. Cho, J. Nat. Sci., 25, 43 (2006).

    Google Scholar 

  24. P. Kalaiarasi and K. V. Pugalendi, Eur. J. Pharmacol., 606, 269 (2009).

    Article  CAS  Google Scholar 

  25. B. K. Yang, S. C. Jeong, H. L. Lee, D. H. Sohn and C. H. Song, Arch. Pharm. Res., 29, 73 (2006).

    Article  Google Scholar 

  26. D. H. Kim, B. K. Yang and S. C. Jeong, Biotechol Lett., 23, 513 (2001).

    Article  CAS  Google Scholar 

  27. B. K. Yang, D. K. Kim, S. C. Jeong, S. Das, Y. S. Choi, J. S. Shin, S. C. Lee and C. H. Song, Biosci. Biotechnol. Biochem., 66, 937 (2002).

    Article  CAS  Google Scholar 

  28. E. J. Cho, H. J. Hwang, S. W. Kim, J. Y. Oh, Y. M. Baek, J. W. Choi, S. H. Bae and J. W. Yun, Appl. Micribiol. Biotechnol., 75, 1257 (2007).

    Article  CAS  Google Scholar 

  29. H. N. Zhang, J. H. He, L. Yuan and J. B. Lin, Life Sci., 73, 2307 (2003).

    Article  CAS  Google Scholar 

  30. H. N. Zang and Z. B. Yuan, Acta. Pharmacol. Sin., 25, 190 (2004).

    Google Scholar 

  31. J. Y. Cha, B. S. Jeon, J. W. Park, G. C. Shin, B. K. Kim, H. K. Kim and Y. S. Cho, J. Life Sci., 14, 676 (2004).

    Article  Google Scholar 

  32. M. J. Abrahamson, Arch. Inter. Med., 164, 486 (2004).

    Article  CAS  Google Scholar 

  33. A. Ceriello, J. Davidson, M. Hanefeld, L. Leiter, L. Monnier, D. Owens, N. Tajima and J. Tuomilehto, Nutr. Metab. Cardiovasc. Dis., 16, 453 (2006).

    Article  CAS  Google Scholar 

  34. I. Inoue, K. Takahashi, S. Noji, T. Awata and K. Negishi, Diabetes Res. Clin. Pract., 36, 143 (2005).

    Article  Google Scholar 

  35. J. W. Dennis, S. Laferte, C. Waghorne, M. L. Breitman and R. S. Kergel, Science, 236, 582 (1987).

    Article  CAS  Google Scholar 

  36. Y. Wang, Z. Yang and X. Wie, Int. J. Biol. Macromol., 47, 534 (2010).

    Article  CAS  Google Scholar 

  37. R. B. Kasetti, M. D. Rajasekhar, V. K. Kondeti, S. S. Fatima, E. G. Kumar, S. Swapna, B. Ramesh and C. A. Rao, Food Chem. Toxicol., 48, 1078 (2010).

    Article  CAS  Google Scholar 

  38. K. Mori, C. Kobayashi, T. Tomita, S. Inatomi and M. Ikeda, Nutr. Res., 28, 335 (2008).

    Article  CAS  Google Scholar 

  39. T. Kiho, M. Kochi, S. Usui, K. Hirano, K. Aizawa and T. Inakurma, Inter. J. Med. Mush., 4, 291 (2002).

    CAS  Google Scholar 

  40. F. E. Ashry, M. F. Mahmoud, N. N. Maraghy and A. F. Ahmed, Food Chem. Toxicol., 50, 1159 (2011).

    Article  Google Scholar 

  41. J. Gao, Z. Q. Lian, P. Zhu and H. B. Zhu, Yao Xue Xue Bao., 46, 669 (2011).

    CAS  Google Scholar 

  42. T. Kiho, A. Yamane, J. Hui, S. Usui and S. Ukai, Biol. Pharm. Bull., 19, 294 (1996).

    Article  CAS  Google Scholar 

  43. M. R. Taskinen, Diabetologia., 46, 733 (2003).

    Article  Google Scholar 

  44. W. V. Brown, L. Clark, J. M. Falko, J. R. Guyton, T. J. Rees, G. Schonfeld and M. F. Lopes-Virella, J. Clin. Lipidol., 2, 335 (2008).

    Article  Google Scholar 

  45. S. D. Proctor and J. C. Mamo, Eur. J. Clin. Invest., 28, 497 (1998).

    Article  CAS  Google Scholar 

  46. J. Stamler, O. Vaccaro, J. D. Neaton and D. Wentworth, Diabetes Care., 16, 434 (1993).

    Article  CAS  Google Scholar 

  47. S. H. Kim, S. H. Hyun and S. Y. Choung, J. Ethnopharmacol., 104, 119 (2006).

    Article  Google Scholar 

  48. R. Jasmine and P. Daisy, Int. J. Biol. Chem., 1, 117 (2007).

    Article  Google Scholar 

  49. N. Jose, T. A. Ajith and K. K. Jananrdhanan, Int. J. Med. Mush., 4, 59 (2002).

    Article  Google Scholar 

  50. E. F. Leonid and L. H. Phillpson, Diabetes, 53, 1942 (2004).

    Article  Google Scholar 

  51. M. Kaya, T. Baran, M. Asan-Ozusaglam, Y. S. Cakmak, K. O. Tozak, A. Mol, A. Mentes and G. Sezen, Biotechnol. Biopro. Eng., 20, 168 (2015).

    Article  CAS  Google Scholar 

  52. S. M. Hong, J. H. Choi, S. J. Jo, S. K. Song, J. M. Lee and T. H. Kusakabe, Biotechnol. Biopro. Eng., 20, 515 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacy, College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea

    Dubok Choi & Myung-Koo Lee

  2. Biotechnology Laboratory, B-K Company Ltd., Jeonbuk, 54008, Korea

    Dubok Choi

  3. Department of Biochemical Polymer Science & Engineering, Chosun University, Gwangju, 61452, Korea

    YuLan Piao, Sun-Jong Yu, Yeon-Woong Lee, Wol-Suk Cha & Hoon Cho

  4. Department of Urology, School of Medicine, Chosun University, Gwangju, 61452, Korea

    Dong-Hoon Lim

  5. Biosystem Course, Division of Applied Sciences, Muroran Institute of Technology, 27-1 Mizumoto, Muroran, 050-8585, Japan

    Young-Cheol Chang

  6. Department of Biotechnology, Dongguk University, Gyeongju, 38066, Korea

    Sang-Shin Park

  7. Leaders in Industry-University Cooperation Foundation, Chosun University, Gwangju, 61452, Korea

    Don-Sang You

Authors
  1. Dubok Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. YuLan Piao
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sun-Jong Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yeon-Woong Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dong-Hoon Lim
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Young-Cheol Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Sang-Shin Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Myung-Koo Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Wol-Suk Cha
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Don-Sang You
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Hoon Cho
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hoon Cho.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Choi, D., Piao, Y., Yu, SJ. et al. Antihyperglycemic and antioxidant activities of polysaccharide produced from Pleurotus ferulae in streptozotocin-induced diabetic rats. Korean J. Chem. Eng. 33, 1872–1882 (2016). https://doi.org/10.1007/s11814-016-0007-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11814-016-0007-8

Keywords

Search

Navigation