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Antibacterial and in vivo reactivity of bioactive glass and poly(vinyl alcohol) composites prepared by melting and sol-gel techniques

  • Biotechnology
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Abstract

Bioactive glass particle is used in the repair of bone defects. This material undergoes a series of surface in vivo reactions, which leads to osteointegration. We evaluated the effect of the bioactive glass synthesis, sol-gel (BG(S)) versus melting (BG(M)), associated with polyvinyl-alcohol (PVA) on in vivo bioactivity with biochemical parameters, liver-kidney histological structure and antibacterial in vitro activity. These composites were testified in many bacteria and implanted in ovariectomized rat. The serum and organs (liver and kidney) of all groups, control and treated rats, were collected to investigate the side effects of our composites, BG(S)-PVA and BG(M)-PVA, in comparison with control and ovariectomized rats. Also, the implants, before and after implantation, were prepared for analysis using physicochemical techniques such as Fourier transform infrared spectroscopy and X-ray diffraction. Our results have shown the stability of natremia, kaliemia, calcemia and phosphoremia. The histological structures of liver and kidney in implanted rats are intact compared to control and ovariectomized rats. BG(S)-PVA is characterized by a higher antibacterial effect on negative and positive gram bacteria than BG(M)-PVA. The physicochemical results have confirmed a progressive degradation of BG(S)-PVA and BG(M)-PVA, while replacing the implant by an apatite layer. But this bioactivity of BG(S)-PVA is faster than BG(M)-PVA. We can therefore confirm, on the one hand, the biocompatibility of our two implants and, on the other hand, the beneficial effect of sol-gel synthesis technique versus melting, both on the antibacterial effect and on the rapid formation of layer hydroxyapatite, and consequently on osteogenesis.

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Authors and Affiliations

  1. University of Rennes 1, UMR CNRS 6226, Campus de Beaulieu, 35042, Rennes, France

    Salha Boulila, Hassane Oudadesse & Bertrand Lefeuvre

  2. Anatomopathology Laboratory, CHU Habib Bourguiba 3029, University of Sfax, Sfax, Tunisia

    Rim Kallel & Tahia Boudawara

  3. Laboratory of Sciences Material and Environment, Faculty of Sciences of Sfax, B.P. 1171, Sfax, 3000, Tunisia

    Salha Boulila & Hafed Elfeki

  4. Refractories, Ceramics and Building Materials Department, National Research Centre, 33El Bohouth St. (Former EL Tahrir st.), Dokki- Giza-P. O., 12622, Egypt

    Mostafa Mabrouk & Amany Mostafa

  5. Biopesticides Team (LPAP), Centre of Biotechnology of Sfax, Sfax University, P.O. Box 1177, Sfax, 3018, Tunisia

    Slim Tounsi & Dhekra Mhalla

  6. Laboratory of biochemical, University Hospital Habib Bourguiba, Avenue El Fardous, 3029, Sfax, Tunisia

    Khansa Chaabouni & Fatma Makni-Ayedi

  7. University of Cadi Ayyad, Marrakech and CNRST Rabat, Rabat, Maroc

    Allal Barroug

  8. Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, University of Sfax, P.O. Box 95, Sfax, 3052, Tunisia

    Salha Boulila & Abdelfattah Elfeki

Authors
  1. Salha Boulila
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  2. Hassane Oudadesse
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  3. Hafed Elfeki
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  4. Rim Kallel
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  5. Bertrand Lefeuvre
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  6. Mostafa Mabrouk
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  7. Slim Tounsi
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  8. Dhekra Mhalla
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  9. Amany Mostafa
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  10. Khansa Chaabouni
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  11. Fatma Makni-Ayedi
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  12. Allal Barroug
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  13. Tahia Boudawara
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  14. Abdelfattah Elfeki
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Correspondence to Hafed Elfeki.

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Boulila, S., Oudadesse, H., Elfeki, H. et al. Antibacterial and in vivo reactivity of bioactive glass and poly(vinyl alcohol) composites prepared by melting and sol-gel techniques. Korean J. Chem. Eng. 33, 1659–1668 (2016). https://doi.org/10.1007/s11814-015-0298-1

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  • DOI: https://doi.org/10.1007/s11814-015-0298-1

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