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The principles and applications of nano-diagnosis system for a nano-biosensor

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Abstract

In this review, the basic principles and research trends of biosensors are briefly described and a nano-sensing system applying QCM (quartz crystal micro-balance), nano-diagnosis methods by AFM (atomic force microscopy) and SNOAM (scanning near-field/atomic force microscopy) is discussed intensively. The principle, construction, and applications of piezoelectric crystal sensors as a universal sensor are reviewed. This review is focused mainly on liquid phase applications, such as immune-sensors, gelation detecting sensors, and cultured cell monitoring sensors. The principle of nano-diagnosis based on the AFM or SNOAM techniques is described in detail. Finally, the binding affinity of peptide probes to proteins using AFM and the visualizing of a hybridized PNA probe on a DNA molecule using SNOAM are evaluated and discussed.

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Authors and Affiliations

  1. Department of Chemical Engineering, Dong-A University, 840 hadan-dong, Saha-gu, Busan, 604-714, Korea

    Jong Min Kim & Sang-Mok Chang

  2. Department of Bioscience and Biotechnology Tokyo University of Technology, 1404-1, Katakura, Hachioji, Tokyo, 192-0982, Japan

    Hiroshi Muramatsu & Karube Isao

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  1. Jong Min Kim
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  2. Sang-Mok Chang
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  3. Hiroshi Muramatsu
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  4. Karube Isao
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Correspondence to Karube Isao.

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Isao Karube is Dean, School of Bionics at the Tokyo University of Technology. He is also the Director of Research at the Center of Advanced Bionics, the National Institute of Advanced Industrial Science and Technology. Dr. Karube received his B.S. in Food Science from Tokyo University of Fisheries in 1966, his M.S. and Dr. Eng. in Chemical Engineering from the Tokyo Institute of Technology in 1969 and 1972, respectively. He also holds an honorary doctorate from the University of Lund, Sweden (1994). Dr. Karube is recipient of numerous prizes, awards, and recognitions, including the Division Award of the Chemical Society of Japan (1986), The Honorable Citizen of Ceret, France (1993), The Toyko Prize for Science and Technology (1994), The Invention Prize, Japan Institute of Invention and Innovation (1995), The Takeda Science Award (1996), the Biosensors 2002 Award, and the Commendation of the Minister of Education, Culture, Sports, Science and Technology (2003). Dr. Karube has served on numerous professional editorial boards or editorial advisory boards of many international journals, including Regional Editor of “Journals of Biocatalysis and Biotransformation” and of “Applied Biochemistry and Biotechnology”; Journal of Biotechnology, Current Opinion in Biotechnology, Biotechnology and Bioengineering, Analytical Letters, Electroanalysis, Sensors and Materials, Enzyme and Microbial Technology, and Bio-medical Materials and Engineering. His current research focuses on the development of biosensors, the design and development of DNA and proteome chips, the design and synthesis of biofunctional molecules, environmental bioengineering, and the design of bionics concepts.

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Kim, J.M., Chang, SM., Muramatsu, H. et al. The principles and applications of nano-diagnosis system for a nano-biosensor. Korean J. Chem. Eng. 28, 987–1008 (2011). https://doi.org/10.1007/s11814-011-0051-3

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