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Micronization of arbutine using supercritical anti-solvent

  • Separation Technology, Thermodynamics
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Abstract

Arbutine has been used as skin whitening agent in cosmetics and pharmaceuticals. The objective of this study was to precipitate arbutine micro-particles using a supercritical anti-solvent. Ethanol and supercritical CO2 were used as solvent and anti-solvent, respectively, under various conditions. The effects of pressure, temperature and solution flow rate on the particles were studied. The particle size and morphology were analyzed by field emission scanning electron microscopy.

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Authors and Affiliations

  1. School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul, 151-744, Korea

    Chan Ik Park, Moon Sam Shin & Hwayong Kim

Authors
  1. Chan Ik Park
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  2. Moon Sam Shin
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  3. Hwayong Kim
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Correspondence to Hwayong Kim.

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Park, C.I., Shin, M.S. & Kim, H. Micronization of arbutine using supercritical anti-solvent. Korean J. Chem. Eng. 25, 581–584 (2008). https://doi.org/10.1007/s11814-008-0098-y

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  • DOI: https://doi.org/10.1007/s11814-008-0098-y

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