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Endothelial function and oxidative stress in diabetes: active profile of the long-acting nitrate pentaerythritol tetranitrate (PETN)

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Clinical Research in Cardiology Supplements Aims and scope

Abstract

Diabetes is an independent risk factor for coronary artery disease. For the occurrence of cardiovascular complications in diabetes, endothelial dysfunction plays an important role. Alterations of the endothelial-dependent coronary blood flow reserve have been shown to be based on the reduced bioavailability of nitric oxide (NO). Therefore, pharmacological approaches, which potentially reduce oxidative stress at the site of the endothelium, may be beneficial. As compared with other nitrates, the long-acting nitrate pentaerythritol tetranitrate (PETN) displays characteristics which may be beneficial for the treatment of endothelial dysfunction: apart from its vasodilatory and anti-ischemic properties, it has been shown to reduce endothelial dysfunction by activating the heme oxygenase-1 (HO-1) system. It also suppresses atherosclerotic vascular alterations. Other than regular nitrates, e.g., isosorbide dinitrate, drug tolerance is not observed. Treatment with pentaerythritol tetranitrate (PETN) may be advantageous in diabetic patients, who frequently present with endothelial dysfunction. Studies in diabetes assessing the effects of pentaerythritol tetranitrate (PETN) on cardiovascular function may display important effects on the active profile of PETN.

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Conflict of interest

The author declares that there is no conflict of interest.

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Authors and Affiliations

  1. Institut für Diabetesforschung der Forschergruppe Diabetes e. V., Am Helmholtz-Zentrum München, Ingolstädter Landstraße 1, 85764, Munich-Neuherberg, Germany

    Oliver Schnell

  2. Acatvis Deutschland GmbH, Langenfeld, Germany

    D. Stalleicken

  3. The 2nd Medical Clinic, Laboratory for Molecular Cardiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany

    A. Daiber

  4. Medizinischen Klinik I – Kardiologie, Pneumologie und Angiologie, Universitätsklinikum der RWTH Aachen, Aachen, Germany

    N. Marx

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  1. Oliver Schnell
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  2. D. Stalleicken
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  3. A. Daiber
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  4. N. Marx
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Correspondence to Oliver Schnell.

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Schnell, O., Stalleicken, D., Daiber, A. et al. Endothelial function and oxidative stress in diabetes: active profile of the long-acting nitrate pentaerythritol tetranitrate (PETN). Clin Res Cardiol Suppl 5 (Suppl 1), 35–41 (2010). https://doi.org/10.1007/s11789-010-0015-x

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  • DOI: https://doi.org/10.1007/s11789-010-0015-x

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