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In vitro corrosion behavior and cytotoxicity property of magnesium matrix composite with chitosan coating

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Abstract

Mg-6%Zn-10%β-Ca3(PO4)2 composite was prepared through powder metallurgy methods with different chitosan coatings on its surface. The properties of the chitosan coatings on the surface of Mg-6%Zn-10%β-Ca3(PO4)2 composite, such as the adhesion ability, the corrosion behavior and the cytotoxicity properties, were investigated, and the microstructure of the chitosan coating was observed by scanning electron microscope (SEM). The results show that chitosan coating improves the corrosion resistance of the magnesium composite specimens significantly. Mg-6%Zn-10%β-Ca3(PO4)2 composite specimens exhibit good corrosion resistance and low pH values in simulated body fluid (SBF) at 37 °C in the immersion test with 7-layer chitosan coating whose relative molecular mass is 30×104 Da. The cytotoxicity tests indicate that Mg-6%Zn-10%β-Ca3(PO4)2 with chitosan coating is nontoxic with a cytotoxicity grade of zero against L-929 cells, which is better than that of uncoated composites.

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Authors and Affiliations

  1. School of Materials Science and Engineering, Central South University, Changsha, 410083, China

    Yi-long Dai  (戴翌龙), Kun Yu  (余琨), Xue-yan Qiao  (乔雪岩) & Yang Yan  (颜阳)

  2. State Key Laboratory of Powder Metallurgy, Central South University, Changsha, 410083, China

    Kun Yu  (余琨), Liang-jian Chen  (陈良建) & Chang Chen  (陈畅)

  3. XiangYa Third Hospital, Central South University, Changsha, 410013, China

    Liang-jian Chen  (陈良建)

Authors
  1. Yi-long Dai  (戴翌龙)
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  2. Kun Yu  (余琨)
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  3. Liang-jian Chen  (陈良建)
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  4. Chang Chen  (陈畅)
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  5. Xue-yan Qiao  (乔雪岩)
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  6. Yang Yan  (颜阳)
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Corresponding author

Correspondence to Kun Yu  (余琨).

Additional information

Foundation item: Project(2012zzts068) supported by the Fundamental Research Funds for the Central Universities of Central South University, China; Project(2010fj3091) supported by the Open Funding of State Key Laboratory of Powder Metallurgy and Science & Technology Foundation, China

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Dai, Yl., Yu, K., Chen, Lj. et al. In vitro corrosion behavior and cytotoxicity property of magnesium matrix composite with chitosan coating. J. Cent. South Univ. 22, 829–834 (2015). https://doi.org/10.1007/s11771-015-2589-4

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  • DOI: https://doi.org/10.1007/s11771-015-2589-4

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