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Preparation and biocompatibility evaluation of poly(D, L-lactide-co-glycine)

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Abstract

D,L-lactide was prepared from D,L-lactic acid by means of polymerization and depolymerization at low vacuum level. Morpholine-2,5-dione (MD) was synthesized from the cyclization of chloroacetyl glycine which was made from chloroacetyl chloride and glycine in the basic condition. A novel copolymer (PLAMD) with D,L-lactide (D,L-LA) and morpholine-2,5-dione (MD) was synthesized using stannous octoate as initiator, and characterized with FT-IR and 1HNMR. The biocompatibility of PLAMD and PLA was investigated by MTT and microscope. The results show that amino acid is introduced into PDLLA main chain. PLAMD has better cell affinity than PLA, so it is a promising biomaterial.

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Authors and Affiliations

  1. School of Materials Science and Engineering, Changzhou University, Changzhou, 213164, China

    Yao-ping Hu  (胡耀平), Lei-jian Cao  (曹雷健) & Qing-hua Li  (李清华)

  2. Institute of Polymer Material Engineering, Jiaxing University, Jiaxing, 314001, China

    Li Gu  (谷俐), Hong-xia Shen  (沈红霞) & Tao Zheng  (郑涛)

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  1. Yao-ping Hu  (胡耀平)
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  2. Lei-jian Cao  (曹雷健)
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  3. Li Gu  (谷俐)
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  4. Qing-hua Li  (李清华)
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  5. Hong-xia Shen  (沈红霞)
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  6. Tao Zheng  (郑涛)
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Corresponding author

Correspondence to Li Gu  (谷俐).

Additional information

Foundation item: Project(21107032) supported by the National Natural Science Foundation of China; Projects(Y406469, Y4110606) supported by the Natural Science Foundation of Zhejiang Province, China; Projects(2008AY2018, 2011AY1048-5, 2011AY1030) supported by the Science Foundation of Jiaxing Science and Technology Bureau, China; Project(2009C21003) supported by the Science and Technology Department of Zhejiang Province, China

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Hu, Yp., Cao, Lj., Gu, L. et al. Preparation and biocompatibility evaluation of poly(D, L-lactide-co-glycine). J. Cent. South Univ. Technol. 19, 1517–1521 (2012). https://doi.org/10.1007/s11771-012-1170-7

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  • DOI: https://doi.org/10.1007/s11771-012-1170-7

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