Abstract
We have reported a case of primitive neuroectodermal tumor/Ewing’s sarcoma (PNET/EWS) in a 32-year-old female who had had no symptoms until the tumor was detected in a general examination after she gave birth. Chest X-ray showed a well-defined, rounded mass in the left lower lung field. Computed tomographic scan of the chest revealed a distinct mass adjacent to the anterolateral thoracic wall. The macroscopic findings had shown a well-capsulated tumor with a stalk emanating from the thoracic wall. PNET/EWS was histologically diagnosed. The tumor was composed of atypical, small round cells. It stained positively with antibodies to the MIC2 gene product. Postoperative adjuvant radiotherapy of 50 Gy was performed. Adjuvant chemotherapies were not performed. Four years later, a small recurrent nodule in the left lung was surgically resected. Since her initial diagnosis, the patient has survived for seven years; in the three years since her second surgery, she has had no other recurrence or metastasis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Kempson R, Fletcher C, Evans H, Hendrickson M, Sibley RK. Malignant neoplasms (Managerial Groups III and IV, Table 1–10). In: Tumors of the soft tissue. 3rd. Washington D.C.: Armed Forces Institute of Pathology, 2001:444–52.
Horowitz ME, Malawer MM, Delaney TF, Tsokos MG. Principles and Practice of Pediatric Oncology. In: 1993:795–821.
Shamberger RC, LaQuaglia MP, Gebhardt MC, Neff JR, Tarbell NJ, Marcus KC, et al. Ewing sarcoma/primitive neuroectodermal tumor of the chest wall: Impact of initial versus delayed resection on tumor margins, survival, and use of radiation therapy. Ann Surg 2003; 238: 563–8.
Martin RC 2nd, Brennan MF. Adult soft tissue Ewing sarcoma or primitive neuroectodermal tumors: Predictors of survival? Arch Surg 2003; 138: 281–5.
Colby TV, Koss MN, Travis WD. Primitive neuroectodermal tumor (malignant small round cell tumor of the thoracopulmonary region). In: Tumors of the lower Respiratory Tract. 3rd. Washington DC: Armed Forces Institute of Pathology, 1995: 310–1.
O’Sullivan MJ, Perlman EJ, Furman J, Humphrey PA, Dehner LP, Pfeifer JD. Visceral primitive peripheral neuroectodermal tumors: A clinicopathologic and molecular study. Hum Pathol 2001; 32: 1109–15.
Rao BN, Hayes FA, Thompson EI Kumar AP, Fleming ID, Green AA, et al. Chest wall resection for Ewing’s sarcoma of the rib: An unnecessary procedure. 1988. Updated in 1995. Ann Thorac Surg 1995; 60: 1454–5.
Paulussen M, Ahrens S, Lehnert M, Taeger D, Hense HW, Wagner A, et al. Second malignancies after Ewing tumor treatment in 690 patients from a cooperative German/Austrian/Dutch study. Ann Oncol 2001; 12: 1619–30.
Shamberger RC, Tarbell NJ, Perez-Atayde AR, Grier HE. Malignant small round cell tumor (Ewing’s-Pnet) of the chest wall in children. J Pediatr Surg 1994; 29: 179–85.
Grier HE, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ, et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 2003; 348: 694–701.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fukushima, M., Koizumi, K., Nakajima, Y. et al. Primitive neuroectodermal tumor/Ewing’s sarcoma with long-term follow-up. Jpn J Thorac Caridovasc Surg 53, 97–101 (2005). https://doi.org/10.1007/s11748-005-0009-7
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s11748-005-0009-7