Skip to main content

Advertisement

Log in

Long-chain polyunsaturated fatty acids in diets for infants: Choices for recommending and regulating bodies and for manufacturers of dietary products

  • Published:
Lipids

Abstract

While the scientific evaluation of the physiologic effects, potential benefits, and risks of dietary preformed long-chain polyunsaturated fatty acids (LCPUFA) for infants have been discussed elsewhere, this manuscript addresses some of the resulting consequences and challenges of interpreting the available knowledge from the perspective of recommending and regulating bodies, and of manufacturers of dietary products and their ingredient materials. Traditionally human milk composition has served as a reference point for infant formula design. With respect to the use of LCPUFA in infant formula, much more emphasis than ever before invested for any other group of micronutrients has been put on clinical studies investigating the potential advantages and disadvantages of LCPUFA in infant foods, including growth, safety aspects, and a variety of other outcome measures.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Abbreviations

AA:

arachidonic acid

DHA:

docosahexaenoic acid

ESPGHAN:

European Society for Paediatric Gastroenterology, Hepatology and Nutrition

FAO:

Food and Agriculture Organization of the United Nations

FDA:

United States Food and Drug Administration

LCPUFA:

long-chain polyunsaturated fatty acids

PUFA:

polyunsaturated fatty acids

WHO:

World Health Organization

WIC:

United States Special Supplemental Food Program for Women, Infants and Children

References

  1. Groziak, S.M., and Miller, G.D. (1998) Dietary Guidelines for Children: Where Are We Heading? J. Nutr. 128, 1836–1838.

    PubMed  CAS  Google Scholar 

  2. Raiten, D.J., Talbot, J.M., and Waters, J.H. (eds.) (1998) Assessment of Nutrient Requirements for Infant Formulas, Life Sciences Research Office, American Society for Nutritional Science, Bethesda.

    Google Scholar 

  3. LSRO Report: Assessment of Nutrient Requirements for Infant Formulas (1998) J. Nutr. 128, 2059S–2063S.

  4. ESPGAN Committee on Nutrition: Aggett, P.J., Haschke, F., Heine, W., Hernell, O., Koletzko, B., Launiala, K., Rey, J., Rubino, A., Schöch, G., Senterre, J., and Tormo, R. (1991) Committee Report. Comment on the Content and Composition of Lipids in Infant Formulas, Acta Paediatr. Scand. 80:887–896.

    PubMed  CAS  Google Scholar 

  5. Commission on the European Communities (1991) Commission Directive of 14 May 1991 on Infant Forumlae and Follow-on Formulae, Off. J. Eur. Comm (L175/36,4.7.1991).

  6. Commission of the European Communities (1996) Commission Directive 94/6 of 16 February 1996 Amending Directive 91/321/EEC on Infant Formulae and Follow-on Formulae, Off. J. European Comm. 39(L49):12–16

    Google Scholar 

  7. Canadian Paediatric Society; Dietitians of Canada: Health Canada (1998) Nutrition for Healthy Term Infants, Minister of Public Works and Government Services, Ottawa.

    Google Scholar 

  8. British Nutrition Foundation (1992) Unsaturated Fatty Acids: Nutritional and Physiological Significance, The Report of the British Nutrition Foundation’s Task Force, Chapman & Hall, London.

    Google Scholar 

  9. World Health Organization/Food and Agriculture Organization (1994) Fats and Oils in Human Nutrition, Food and Agriculture Organization, Rome.

    Google Scholar 

  10. Herzog, M., von Schenck, U., Böhles, H.J., et al. (1998) Long-Chain Polyunsaturated Fatty Acid (LCPUFA) Status of Infants with Phenylketonuria (PKU) During the First Year of Life: A Randomised Trial, J. Inherit. Metab. Dis. 21, 12 (Abstract).

    Google Scholar 

  11. Harvie, A., Biasucci, G., Rive, E., Robinson, P., Davidson, D.C., Walter, J.H., White, F., Largilliere, C., Campistol, J., and Baldellou, A. (1998) Randomised Controlled Trial of a Long Chain Polyunsaturated Fatty Acid (LC PUFA) Supplemented Low Phe Infant Formula [Abstract], J. Inherit. Metab. Dis. 21, 13.

    Article  Google Scholar 

  12. Koletzko, B. (1998) Can Infant Formula Be Made More Similar to Human Milk? Proceedings of the 16th International Congress on Nutrition—Nutrition Montreal 97, Fitzpatrick, D.W., L’Abbe, M.L., eds., pp. 97–100, Canadian Federation of Biological Societies, Ottawa.

    Google Scholar 

  13. ESPGAN Committee on Nutrition, Guidelines on Infant Nutrition (1977) Acta Paediatr. Scand. Suppl. 262, 1–20.

    Google Scholar 

  14. Kunz, C., Rodriguez, M., Koletzko, B., and Jensen, R.G., Composition and Biological Effects of Human Milk. I. General Aspects, Proteins and Carbohydrates, Clin. Perinatol. (in press).

  15. Rodriguez, M., Koletzko, B., Kunz, C., and Jensen, R.G., Composition and Biological Effects of Human Milk, Clin. Perinatol. in press.

  16. Demmelmair, H., Baumheuer, M., Koletzko, B., Dokoupil, K., and Kratl, G. (1998) Metabolism of U13C-Labeled Linoleic Acid in Lactating Women, J. Lipid Res. 39, 1389

    PubMed  CAS  Google Scholar 

  17. Genzel, B.O., Wahle, J., and Koletzko, B. (1997) Fatty Acid Composition of Human Milk During the First Month After Term and Preterm Delivery, Eur. J. Pediatr. 156(2), 142–147.

    Article  Google Scholar 

  18. Koletzko, B. (1997) Importance of Dietary Lipids, in Nutrition During Infancy. Principles and Practice, (Tsang. R., Zlotkin, S.H., Nichols, B., and Hansen, J.W., eds.) 1st edn. Digital Educational Publishing, 1997, Cincinnati, p. 123–153.

  19. Koletzko, B., Thiel, I., and Abiodun, P.O. (1992) The Fatty Acid Composition of Human Milk in Europe and Africa, J. Pediatr. 120, S62-S70.

    Article  PubMed  CAS  Google Scholar 

  20. von Schenck, U., Bender Götze, C., and Koletzko, B. (1997) Persistence of Neurological Damage Induced by Dietary Vitamin B-12 Deficiency in Infancy, Arch. Dis. Child 77, 137–139.

    Article  Google Scholar 

  21. Department of Health, Guidelines on the Nutritional Assessment of Infant Formulas, 1996, Report on Health and Social Subjects. The Stationary Office, London.

    Google Scholar 

  22. Carlson, S.E., Cooke, R.J., Werkman, S.H., and Tolley, E.A. (1992) First-Year Growth of Preterm Infants Fed Standard Compared to Marine Oil n−3 Supplemented Formula, Lipids 27, 901–907.

    PubMed  CAS  Google Scholar 

  23. ESPGHAN Committee on Nutrition (1998) Comment on the Vitamin E Content in Infant Formulas, Follow-On Formulas and Formulas for Low Birthweight Infants, J. Pediatr. Gastroenterol. Nutr. 26, 351–352.

    Google Scholar 

  24. Decsi, T., Burus, I., and Koletzko, B. (1998) Effects of Dietary Long-Chain Polyunsaturated Fatty Acids on Plasma Amino Acids and Indices of Protein Metabolism in Infants: Results from a Randomised Clinical Trial, Ann. Nutr. Metab. 42, 195–201.

    Article  PubMed  CAS  Google Scholar 

  25. Decsi, T., Zaknun, D., Zaknun, J., Sperl, W., and Koletzko, B. (1995) Long-Chain Polyunsaturated Fatty Acids in Children with Severe Protein-Energy Malnutrition With and Without Human Immunodeficiency Virus-1 Infection, Am. J. Clin. Nutr. 62, 1283–1288.

    PubMed  CAS  Google Scholar 

  26. Mack, D., Koletzko, B., Cunnane, S., Cutz, E., and Griffiths, A. (1989) Acrodermatitis Enteropathica with Normal Serum Zinc Levels: Diagnostic Value of Small Bowel Biopsy and Essential Fatty Acid Determination, Gut 30, 10–19.

    Google Scholar 

  27. Kyle, D.J., and Ratlege, C. (eds) Industrial Application of Single-Cell Oils, American Oil Chemists’ Society, Champaign, 1992.

    Google Scholar 

  28. Kouzaki, N., Kawashima, H., Chung, M.C., and Shimizu, S. (1995) Purification and Characterization of Two Forms of Cytochrome b5 from an Arachidonic Acid-Producing Fungus, Mortierella hygrophila, Biochim. Biophys. Acta 1256, 319–326.

    Google Scholar 

  29. Kelley, D.S., Taylor, P.C., Nelson, G.J., Schmidt, P.C., Mackey, B.E., and Kyle, D. (1997) Effects of Dietary Arachidonic Acid on Human Immune Response, Lipids 32, 449–456.

    Article  PubMed  CAS  Google Scholar 

  30. Reiss, J. (1993) Biotoxic Activity in the Mucorales, Mycopathologia 121, 123–127.

    Article  Google Scholar 

  31. Withers, N.W., Tuttle, R.C., Holz, G.G., Beach, D.H., Goad L.J., and Goodwin, T.W. (1978) Dehydrodinosterol, Dinosterone and Related Sterols of a Non-Photosynthetic Dinoflagellate, Crypthecodinium cohnii, Phytochemistry 17, 1987–1989.

    Article  CAS  Google Scholar 

  32. Davey, G., Smith, J.M., and Kalmakoff, J. (1973) Purification and Properties of a Toxin Isolated from Mortierella wolfii, Infect. Immun. 8, 882–886.

    PubMed  CAS  Google Scholar 

  33. Koletzko, B., Aggett, P.J., Bindels, J. et al. (1998) Growth. Development and Differentiation: A Functional Food Science Approach. Brit. J. Nutr. 80, S5-S45.

    Article  PubMed  CAS  Google Scholar 

  34. Koletzko, B. (1997) Lipid Supply for Infants with Special Needs, Eur. J. Med. Res. 2, 69–73.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Berthold Koletzko.

About this article

Cite this article

Koletzko, B., Sinclair, A. Long-chain polyunsaturated fatty acids in diets for infants: Choices for recommending and regulating bodies and for manufacturers of dietary products. Lipids 34, 215–220 (1999). https://doi.org/10.1007/s11745-999-0356-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11745-999-0356-x

Keywords

Navigation