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Effect of apolipoprotein E polymorphism on serum lipoprotein response to saturated fatty acids

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Lipids

Abstract

This report summarizes two studies which investigated the effects of apolipoprotein E (apoE) polymorphism on the serum total cholesterol (TC) and lipoprotein cholesterol responses to 8∶0+10∶0 and 12∶0 diets (Study I) and 14∶0, 16∶0, and 18∶0 diets (Study II). Eighteen healthy premenopausal women (3 apoE 3/2, 12 apoE 3/3, 3 apoE 4/3) in study I and another 18 healthy premenopausal women (4 apoE 3/2, 10 apoE 3/3, 3 apoE 4/3, 1 apoE 4/2) in study II consumed a baseline diet providing 40 en% total fat, 11 en % 18∶2, 15 en% 18∶1, 11.5 en% saturated fat for the first week of each 5-wk period. The experimental diets for both studies provided 40 3n% total fat, 13–14 en% as one of five test saturated fatty acids (SFA), 14–16 en% 18∶1, and 3–4 en% 18∶2. Analysis by apoE phenotypes showed that both the 8∶0+10∶0 diet and the 12∶0 diet in Study Linduced significant increases in serum TC in subjects with different apoE phenotypes with the exception of apoE 3/2 in the medium-chain triglyceride group. In contrast, in Study II, individuals with apoE 4/3 consuming the 14∶0 diet showed significant increases in serum TC, high density lipoprotein-cholesterol (HDL-C), and HDL2-C, but the same subjects consuming the 16∶0 diet showed significant increases in serum TC and low density lipoprotein-cholesterol. The findings from both studies indicated serum lipoprotein responses to SFA were different and the variation of responsiveness may be regulated, at least in part, by apoE polymorphism, especially when 14∶0, 16∶0, or 18∶0 was consumed.

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Abbreviations

apo:

apolipoprotein

ANOVA:

analysis of variance

CETP:

cholesteryl ester transfer protein

HDL-C:

high density lipoprotein-cholesterol

IDL:

intermediate density lipoprotein

IEE:

isoelectric focusing

LDL-C:

low density lipoprotein-cholesterol

LCAT:

lceithin cholesterol acyl transferase

MCT:

medium-chain triglyceride

MNC:

mononuclear cell

MUFA:

monounsaturated fatty acid

PUFA:

polyunsaturated fatty acid

SFA:

saturated fatty acid

TC:

total cholesterol

TG:

triglyceride

VLDL-C:

very low density lipoprotein-cholesterol

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Authors and Affiliations

  1. Department of Human Nutrition and Food Management, The Ohio State University, 302 Campbell Hall, 1787 Neil Ave., 43210, Columbus, OH

    Tim K. Tso, Sunmin Park, Yu-Hwai Tsai, Glenn Williams & Jean T. Snook

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  1. Tim K. Tso
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  2. Sunmin Park
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  3. Yu-Hwai Tsai
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  4. Glenn Williams
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  5. Jean T. Snook
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Correspondence to Jean T. Snook.

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Tso, T.K., Park, S., Tsai, YH. et al. Effect of apolipoprotein E polymorphism on serum lipoprotein response to saturated fatty acids. Lipids 33, 139–148 (1998). https://doi.org/10.1007/s11745-998-0189-7

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  • DOI: https://doi.org/10.1007/s11745-998-0189-7

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