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Lysophospholipids from the Guangxi Sponge Spirastrella purpurea

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  • Published:
Lipids

Abstract

Four known (1–4) and two new (5 and 6) lysophospholipids were isolated from the sponge Spirastrella purpurea from Weizhou Island, Guangxi Autonomous Region, China. The structures of the new compounds (5 and 6) were elucidated by detailed spectroscopic techniques, including 1D and 2D NMR (1H and 13C NMR, 1H–1H COSY, HSQC, and HMBC) as well as mass spectrometry and optical rotation experiments. The known compounds (1–4) were identified by comparison of their spectroscopic data and specific optical rotation with those reported in the literature. The isolated compounds displayed various moderate in vitro antifungal activities against four fungi (Cryptococcus neoformans, Candida glabrata, Trichophyton rubrum, and Aspergillus fumigatus), whereas they displayed no neuroprotective activity against Aβ25-35-induced SH-SY5Y cell damage.

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Fig. 1
Fig. 2

Abbreviations

1D:

One dimensional

2D:

Two dimensional

CH2Cl2 :

Dichloromethane

COSY:

Correlation spectroscopy

DEPT:

Distortionless enhancement by polarization transfer

DMSO:

Dimethyl sulfoxide

ESI:

Electrospray ionization

Et2O:

Ethyl ether

HMBC:

Heteronuclear multiple bond correlation

HPLC:

High-performance liquid chromatography

HR:

High resolution

HSQC:

Heteronuclear singular quantum correlation

IR:

Infrared

LC:

Liquid chromatography

LPL:

Lysophospholipid

MeOH:

Methanol

MIC:

Minimum inhibitory concentration

MS:

Mass spectrometry

MTT:

Methyl thiazolyl tetrazolium bromide

NMR:

Nuclear magnetic resonance

PAF:

Platelet activating factor

RPMI:

Roswell Park Memorial Institute

SRB:

Sulforhodamine B

TLC:

Thin-layer chromatography

TOF:

Time of flight

UV:

Ultraviolet

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Acknowledgments

This research work was financially supported by the National Natural Science Foundation of China (Nos. 81001397, 21162016, and 21362024), Young Scientists Training Program of Jiangxi Province (No. 20133BCB23004), Natural Science Foundation of Jiangxi Province (No. 20114BAB205034), and Foundation of Education Department of Jiangxi Province (No. GJJ12028). We are also grateful to Prof. J.-H. Li (Institute of Oceanology, Chinese Academy of Sciences) for identification of the animal.

Conflict of interest

All authors declare that there are no conflicts of interest.

Author information

Authors and Affiliations

  1. School of Pharmacy, Nanchang University, 461 Bayi Road, Nanchang, 330006, People’s Republic of China

    Kun Lin, Peng Yang, Hui Yang & Shui-Chun Mao

  2. Center of Analysis and Testing, Nanchang University, Nanchang, 330047, People’s Republic of China

    Ai-Hong Liu

  3. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai, 201203, People’s Republic of China

    Li-Gong Yao & Yue-Wei Guo

Authors
  1. Kun Lin
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  2. Peng Yang
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  3. Hui Yang
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Correspondence to Shui-Chun Mao.

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Lin, K., Yang, P., Yang, H. et al. Lysophospholipids from the Guangxi Sponge Spirastrella purpurea . Lipids 50, 697–703 (2015). https://doi.org/10.1007/s11745-015-4028-6

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  • DOI: https://doi.org/10.1007/s11745-015-4028-6

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