Abstract
Hei Yi Zhuang is an isolated subgroup of the Zhuang minority in China. This study was designed to compare the difference in the hepatic lipase gene (LIPC) −514C/T polymorphism and its association with lipid profiles between the Guangxi Hei Yi Zhuang and Han populations. Genotyping of the LIPC −514C/T was performed in 873 subjects of Hei Yi Zhuang and 867 participants of Han Chinese. The frequency of −514T allele was 43.47% in Hei Yi Zhuang, and 36.10% in Han (P < 0.001). The frequencies of CC, CT and TT genotypes were 30.01, 53.04 and 16.95% in Hei Yi Zhuang, and 40.95, 45.91 and 13.14% in Han (P < 0.001); respectively. Serum high-density lipoprotein cholesterol (HDL-C) and apolipoprotein B levels in both ethnic groups were higher in LIPC −514T carriers than in C carriers. In addition, serum triglyceride levels in Han were higher in TT genotype individuals than in CC genotype subjects (P < 0.05). Serum HDL-C levels were positively correlated with age, alcohol consumption and LIPC −514C/T genotypes, and negatively associated with hypertension and cigarette smoking in Hei Yi Zhuang (P < 0.05–0.01), whereas HDL-C levels were positively correlated with age, alcohol consumption and LIPC −514C/T genotypes, and negatively associated with body mass index and cigarette smoking in Han (P < 0.05–0.001). The differences in serum HDL-C levels between the two ethnic groups might partially attribute to the differences in the LIPC −514C/T polymorphism.
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Abbreviations
- ANCOVA:
-
Analysis of covariance
- Apo:
-
Apolipoprotein
- BMI:
-
Body mass index
- CHD:
-
Coronary heart disease
- DNA:
-
Deoxyribonucleic acid
- HDL-C:
-
High-density lipoprotein cholesterol
- HL:
-
Hepatic lipase
- LDL-C:
-
Low-density lipoprotein cholesterol
- LIPC :
-
Hepatic lipase gene
- PCR:
-
Polymerase chain reaction
- SNP:
-
Single nucleotide polymorphisms
- TC:
-
Total cholesterol
- TG:
-
Triglyceride
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This study was supported by the National Natural Science Foundation of China (No: 30360038).
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Wu, J., Yin, R., Lin, W. et al. Hepatic Lipase Gene −514C/T Polymorphism in the Guangxi Hei Yi Zhuang and Han Populations. Lipids 43, 733–740 (2008). https://doi.org/10.1007/s11745-008-3204-3
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DOI: https://doi.org/10.1007/s11745-008-3204-3