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5,9,23-Triacontatrienoic methyl ester, an elastase inhibitor from the marine sponge Chondrilla nucula

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Lipids

Abstract

A polyethylenic fatty ester was isolated from the marine sponge Chondrilla nucula. The structure was elucidated through NMR spectral data and MS analysis as 5,9,23-triacon-tatrienoic methyl ester 1. Compound 1 is an elastase inhibitor [ID50=10 μg/mL (2·10−5M)].

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Abbreviations

ID50 :

dose that is inhibitory in 50% of tests

PPE:

porcine pancreatic elastase

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Authors and Affiliations

  1. Laboratoire de Chimie, ESA 8041 C.N.R.S., Muséum National d'Histoire Naturelle, F-75005, Paris, France

    Michèle Meyer & Michèle Guyot

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  1. Michèle Meyer
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  2. Michèle Guyot
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Correspondence to Michèle Guyot.

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Meyer, M., Guyot, M. 5,9,23-Triacontatrienoic methyl ester, an elastase inhibitor from the marine sponge Chondrilla nucula . Lipids 37, 1109–1111 (2002). https://doi.org/10.1007/s11745-002-1007-y

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  • DOI: https://doi.org/10.1007/s11745-002-1007-y

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