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High oleic acid oil suppresses lung tumorigenesis in mice through the modulation of extracellular signal-regulated kinase cascade

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Lipids

Abstract

This study was undertaken to estimate the effect of dietary high oleic acid oil (OA) on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in mice. Diet containing 10% oil was fed to mice through experimental periods. On day 30 after NNK injection (100 mg/kg body weight, i.p.), the treatment increased the level of prostaglandin E2 (PGE2) as well as proliferating cell nuclear antigen, a marker of cell proliferation in a high linoleic acid oil (LA)-fed group but not in an OA-fed group. The NNK treatment also induced the activation of an extracellular signal-regulated kinase (Erk) cascade (Erk, Mek and Raf-1) in an LA-fed group. On the other hand, OA feeding abolished the NNK-induced activation of the Erk cascade. In conjugation with these events, OA feeding reduced lung tumor incidence and tumor multiplicity (percentage of mice with tumors) in mice compared with LA feeding at the 20th experimental week. These results suggest that OA suppresses lung tumorigenesis and that this suppression is correlated with the inhibition of PGE2 production and inactivation of the Erk cascade.

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Abbreviations

Erk:

extracellular signal-regulated kinase

LA:

high linoleic acid sunflower oil

NNK:

4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

OA:

high oleic acid peanut oil

PCNA:

proliferating cell nuclear antigen

PGE2 :

prostaglandin E2

RIPA:

radioimmunoprecipitation assay

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Authors and Affiliations

  1. College of Bioresource Sciences, Nihon University, Fujisawa, 252-8510, Kanagawa, Japan

    Tatsuya Yamaki, Tatsuo Endo, Chinami Matsuyama, Hitomi Kumagai, Mitsuyoshi Miyahara & Hidetoshi Sakurai

  2. Faculty of Food and Biochemical Technology, Institute of Chemical Technology, CZ-16628, Prague 6, Czech Republic

    Jan Pokorny

  3. Department of Food Science Research for Health, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, 162-8636, Tokyo, Japan

    Tomohiro Yano, Haruna Satoh, Sung Jae Shin & Kiyokazu Hagiwara

Authors
  1. Tatsuya Yamaki
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  2. Tomohiro Yano
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  3. Haruna Satoh
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  4. Tatsuo Endo
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  5. Chinami Matsuyama
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  6. Hitomi Kumagai
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  7. Mitsuyoshi Miyahara
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  10. Sung Jae Shin
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  11. Kiyokazu Hagiwara
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Correspondence to Tomohiro Yano.

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Yamaki, T., Yano, T., Satoh, H. et al. High oleic acid oil suppresses lung tumorigenesis in mice through the modulation of extracellular signal-regulated kinase cascade. Lipids 37, 783–788 (2002). https://doi.org/10.1007/s11745-002-0961-8

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  • DOI: https://doi.org/10.1007/s11745-002-0961-8

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