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Impaired lipoprotein metabolism in obese offspring of streptozotocin-induced diabetic rats

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Lipids

Abstract

The time course of changes in lipoprotein metabolism of obese offspring of mildly diabetic rats was studied with respect to serum lipoprotein composition as well as LCAT and tissue lipoprotein lipase (LPL) activities. Mild hyperglycemia in pregnant rats was induced by intraperitoneal injection of streptozotocin on day 5 of gestation. Control pregnant rats were injected with citrate buffer. At birth, obese pups had higher serum glucose, insulin, and lipoprotein (VLDL, LDL-HDL1, HDL2–3) levels than control pups. After 1 mon of life, all of these parameters in obese rats became similar to those of controls. However, LCAT, adipose tissue LPL, and hepatic triacylglycerol lipase activities were high. At 2 mon of age, VLDL-TAG levels were higher in obese females than in controls. By the age of 3 mon, obese offspring had developed insulin resistance with hyperglycemia, hyperinsulinemia, and higher serum lipoprotein concentrations. Indeed, qualitative abnormalities of lipoproteins were seen and were typical of obese and diabetic human beings. Fetal hyperinsulinemia should be considered as a risk factor for later metabolic diseases, including dyslipoproteinemia.

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Abbreviations

Apo:

apolipoproteins

EC:

esterified cholesterol

HTGL:

hepatic triacylglycerol lipase

LPL:

lipoprotein lipase

PL:

phospholipid

TAG:

triacylglycerol

UC:

unesterified cholesterol

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Author information

Authors and Affiliations

  1. Laboratory of Animal Physiology, Tlemcen University, Algeria

    Hafida Merzouk

  2. AST, University of Abomey Calavi, Cotonou, Benin

    Kabirou Moutairou

  3. UPRES 2422, Lipids and Nutrition, Bourgogne University, 6 Bd. Gabriel., 21000, Dijon, France

    Sihem Madani, Aziz Hichami, Josiane Prost, Jacques Belleville & Naim Akhtar Khan

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  1. Hafida Merzouk
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  2. Sihem Madani
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  3. Aziz Hichami
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  4. Josiane Prost
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  5. Kabirou Moutairou
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  6. Jacques Belleville
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  7. Naim Akhtar Khan
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Merzouk, H., Madani, S., Hichami, A. et al. Impaired lipoprotein metabolism in obese offspring of streptozotocin-induced diabetic rats. Lipids 37, 773–781 (2002). https://doi.org/10.1007/s11745-002-0960-9

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  • DOI: https://doi.org/10.1007/s11745-002-0960-9

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