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Enlargement of Nanoemulsion Region in Pseudo-ternary Mixing Diagrams for a Drug Delivery System

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Journal of Surfactants and Detergents

Abstract

The purpose of this research was to develop the pseudo-ternary mixing diagrams for a potential drug delivery system consisting of vitamin E (potential drug) + soybean oil + surfactant + co-surfactant (anhydrous glycerol) + water. The potential drug (vitamin E) was loaded in the oil phase. The effects of different surfactants (pure and mixed) on the mixing diagrams, especially on the nanoemulsion region, were investigated. The influence of the drug loading level on the mixing diagrams was also determined. The surfactants studied were polyethoxylated (20) sorbitan monolaurate, polyethoxylated (20) sorbitan monooleate, polyethoxylated (35) castor oil and their mixtures. The size (area) of the nanoemulsion region of the mixing diagrams was found to be dependent on the type of surfactant used and the loading level of the drug (vitamin E).

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Acknowledgments

Financial support for this research is provided by NSERC in the form of a discovery grant awarded to Professor Rajinder Pal.

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Authors and Affiliations

  1. Department of Chemical Engineering, University of Waterloo, Waterloo, ON, N2L 3G1, Canada

    Ziheng Wang & Rajinder Pal

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  1. Ziheng Wang
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  2. Rajinder Pal
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Correspondence to Rajinder Pal.

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Wang, Z., Pal, R. Enlargement of Nanoemulsion Region in Pseudo-ternary Mixing Diagrams for a Drug Delivery System. J Surfact Deterg 17, 49–58 (2014). https://doi.org/10.1007/s11743-013-1497-6

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  • DOI: https://doi.org/10.1007/s11743-013-1497-6

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