Morjaria JB, Malerba M, Polosa R (2010) Biologic and pharmacologic therapies in clinical development for the inflammatory response in COPD. Drug Discov Today 15:396–405
CAS
Article
Google Scholar
Vestbo J, Hurd SS, Agustí AG et al (2013) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 187:347–365
CAS
Article
Google Scholar
Lozano R, Naghavi M, Foreman K et al (2012) Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380(9859):2095–2128
Article
Google Scholar
Falk JA, Kadiev S, Criner GJ et al (2008) Cardiac disease in chronic obstructive pulmonary disease. Proc Am Thorac Soc 5:543–548
Article
Google Scholar
MacNee W (2005) Pathogenesis of chronic obstructive pulmonary disease. Proc Am Thorac Soc 2:258–266
CAS
Article
Google Scholar
Mathers CD, Loncar D (2006) Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3(11):e442
Article
Google Scholar
U.S. Department of Health and Human Services (1984) The health consequences of smoking: chronic obstructive lung disease. U.S. Department of Health and Human Services, Public Health Service, Office on Smoking and Health, Rockville
U.S. Department of Health and Human Services (2004) The health consequences of smoking: a report of the Surgeon General. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, Atlanta
Ezzati M, Lopez AD (2003) Estimates of global mortality attributable to smoking in 2000. Lancet 362:847–852
Article
Google Scholar
U.S. Department of Health and Human Services (1990) The health benefits of smoking cessation. U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health. DHHS Publication No. (CDC) 90-8416
Hersh CP, DeMeo DL, Al-Ansari E et al (2004) Predictors of survival in severe, early onset COPD. Chest 126:1443–1451
Article
Google Scholar
Jimenez-Ruiz CA, Masa F, Miravitlles M et al (2001) Smoking characteristics: differences in attitudes and dependence between healthy smokers and smokers with COPD. Chest 119:1365–1370
CAS
Article
Google Scholar
van der Meer RM, Wagena EJ, Ostelo RW et al (2003) Smoking cessation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.cd002999
Article
PubMed
PubMed Central
Google Scholar
Tashkin DP (2015) Smoking cessation in chronic obstructive pulmonary disease. Semin Respir Crit Care Med 36:491–507. https://doi.org/10.1055/s-0035-1555610
Article
PubMed
Google Scholar
Polosa R, Rodu B, Caponnetto P, Maglia M, Raciti C (2013) A fresh look at tobacco harm reduction: the case for the electronic cigarette. Harm Reduct J 4(10):19. https://doi.org/10.1186/1477-7517-10-19
Article
Google Scholar
O’Leary R, Polosa R (2020) Tobacco harm reduction in the 21st century. Drugs Alcohol Today 20(3):219–234. https://doi.org/10.1108/DAT-02-2020-0007
Article
Google Scholar
Morjaria JB, Mondati E, Polosa R (2017) E-cigarettes in patients with COPD: current perspectives. Int J Chron Obstruct Pulmon Dis 1(12):3203–3210. https://doi.org/10.2147/COPD.S135323
Article
Google Scholar
Polosa R, Morjaria JB, Prosperini U, Busà B, Pennisi A, Malerba M, Maglia M, Caponnetto P (2020) COPD smokers who switched to e-cigarettes: health outcomes at 5-year follow up. Ther Adv Chronic Dis 10(11):2040622320961617. https://doi.org/10.1177/2040622320961617
CAS
Article
Google Scholar
Polosa R, Farsalinos K, Prisco D (2019) Health impact of electronic cigarettes and heated tobacco systems. Intern Emerg Med 14(6):817–820. https://doi.org/10.1007/s11739-019-02167-4
Article
PubMed
Google Scholar
https://tobaccobusiness.com/philip-morris-international-releases-2020-third-quarter-financial-report/. Accessed 4 Jan 2021
https://www.bat.com/group/sites/UK__9D9KCY.nsf/vwPagesWebLive/DOAWWGJT/$file/BAT_Annual_Report_and_Form_20-F_2019.pdf. Accessed 4 Jan 2021
Haziza C, de La Bourdonnaye G, Merlet S, Benzimra M, Ancerewicz J, Donelli A, Baker G, Picavet P, Lüdicke F (2016) Assessment of the reduction in levels of exposure to harmful and potentially harmful constituents in Japanese subjects using a novel tobacco heating system compared with conventional cigarettes and smoking abstinence: a randomized controlled study in confinement. Regul Toxicol Pharmacol 81:489–499. https://doi.org/10.1016/j.yrtph.2016.09.014
CAS
Article
PubMed
Google Scholar
Gale N, McEwan M, Camacho OM, Hardie G, Murphy J, Proctor CJ (2020) Changes in biomarkers of exposure on switching from a conventional cigarette to the glo tobacco heating product: a randomized, controlled ambulatory study. Nicotine Tob Res 10:ntaa135. https://doi.org/10.1093/ntr/ntaa135(Epub ahead of print)
CAS
Article
Google Scholar
https://www.fda.gov/news-events/press-announcements/fda-authorizes-marketing-iqos-tobacco-heating-system-reduced-exposure-information. Accessed 4 Jan 2021
Global Initiative For Chronic Obstructive Lung Disease (2008) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (updated 2008). http://goldcopd.org. Accessed 4 Jan 2021
Polosa R, Morjaria JB, Caponnetto P, Prosperini U, Russo C, Pennisi A, Bruno CM (2016) Evidence for harm reduction in COPD smokers who switch to electronic cigarettes. Respir Res 17(1):166. https://doi.org/10.1186/s12931-016-0481-x
Article
PubMed
PubMed Central
Google Scholar
Polosa R, Morjaria JB, Prosperini U, Russo C, Pennisi A, Puleo R, Caruso M, Caponnetto P (2018) Health effects in COPD smokers who switch to electronic cigarettes: a retrospective-prospective 3-year follow-up. Int J Chron Obstruct Pulmon Dis. 22(13):2533–2542. https://doi.org/10.2147/COPD.S161138
Article
Google Scholar
Jones PW, Harding G, Berry P et al (2009) Development and first validation of the COPD assessment test. Eur Respir J 34:648–654
CAS
Article
Google Scholar
Kon SS, Canavan JL, Jones SE et al (2014) Minimum clinically important difference for the COPD assessment test: a prospective analysis. Lancet Respir Med 2:195–203
Article
Google Scholar
ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories (2002) ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med 166:111–117
Article
Google Scholar
Anthonisen NR, Connett JE, Kiley JP et al (1994) Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The lung health study. JAMA 272:1497–1505
CAS
Article
Google Scholar
Burchfiel CM, Marcus EB, Curb JD et al (1995) Effects of smoking and smoking cessation on longitudinal decline in pulmonary function. Am J Respir Crit Care Med 151:1778–1785
CAS
Article
Google Scholar
Kanner RE, Connett JE, Williams DE et al (1999) Effects of randomized assignment to a smoking cessation intervention and changes in smoking habits on respiratory symptoms in smokers with early chronic obstructive pulmonary disease: the lung health study. Am J Med 106:410–416
CAS
Article
Google Scholar
Xu SS, Meng G, Yan M, Gravely S, Quah ACK, Ouimet J, O’Connor RJ, Sutanto E, Yoshimi I, Mochizuki Y, Tabuchi T, Fong GT (2020) Reasons for regularly using heated tobacco products among adult current and former smokers in Japan: finding from 2018 ITC Japan Survey. Int J Environ Res Public Health 17(21):8030. https://doi.org/10.3390/ijerph17218030
Article
PubMed Central
Google Scholar
Tompkins CNE, Burnley A, McNeill A, Hitchman SC (2020) Factors that influence smokers’ and ex-smokers’ use of IQOS: a qualitative study of IQOS users and ex-users in the UK. Tob Control. https://doi.org/10.1136/tobaccocontrol-2019-055306(Epub ahead of print)
Article
PubMed
Google Scholar
Aaron SD (2014) Management and prevention of exacerbations of COPD. BMJ 349:g5237
Article
Google Scholar
Feldman C, Anderson R (2013) Cigarette smoking and mechanisms of susceptibility to infections of the respiratory tract and other organ systems. J Infect 67:169–184
Article
Google Scholar
Almirall J, Bolíbar I, Serra-Prat M, Roig J, Hospital I, Carandell E, Agustí M, Ayuso P, Estela A, Torres A, Community-Acquired Pneumonia in Catalan Countries (PACAP) Study Group (2008) New evidence of risk factors for community-acquired pneumonia: a population-based study. Eur Respir J. 31(6):1274–1284. https://doi.org/10.1183/09031936.00095807
CAS
Article
PubMed
Google Scholar
Lawrence H, Hunter A, Murray R, Lim WS, McKeever T (2019) Cigarette smoking and the occurrence of influenza—systematic review. J Infect 79(5):401–406. https://doi.org/10.1016/j.jinf.2019.08.014
CAS
Article
PubMed
Google Scholar
Au DH, Bryson CL, Chien JW et al (2009) The effects of smoking cessation on the risk of chronic obstructive pulmonary disease exacerbations. J Gen Intern Med 24:457–463
Article
Google Scholar
Greulich T, Koczulla AR, Nell C et al (2015) Effect of a three-week inpatient rehabilitation program on 544 consecutive patients with very severe COPD: a retrospective analysis. Respiration 90(4):287–292
Article
Google Scholar
Caponnetto P, Maglia M, Prosperini G, Busà B, Polosa R (2018) Carbon monoxide levels after inhalation from new generation heated tobacco products. Respir Res 19(1):164. https://doi.org/10.1186/s12931-018-0867-z
CAS
Article
PubMed
PubMed Central
Google Scholar
Berkovitch A, Kivity S, Klempfner R et al (2015) Time-dependent relation between smoking cessation and improved exercise tolerance in apparently healthy middle-age men and women. Eur J Prev Cardiol 22:807–814
Article
Google Scholar
Scanlon PD, Connett JE, Waller LA et al (2000) Smoking cessation and lung function in mild-to-moderate chronic obstructive pulmonary disease. The Lung Health Study. Am J Respir Crit Care Med. 161(2 Pt 1):381–390
CAS
Article
Google Scholar
Tashkin DP, Rennard S, Taylor Hays J, Lawrence D, Marton JP, Lee TC (2011) Lung function and respiratory symptoms in a 1-year randomized smoking cessation trial of varenicline in COPD patients. Respir Med 105(11):1682–1690
CAS
Article
Google Scholar