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Endothelial regulation of coronary microcirculation in health and cardiometabolic diseases

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Abstract

Cardiometabolic disorders have been shown to impair coronary microvascular functions leading to diminished cardiac performance and increased mortality. In this review, we focus on the molecular pathomechanisms of impaired endothelium-dependent and flow-induced dysregulation of coronary vasomotor tone in cardiometabolic disorders such as obesity, diabetes mellitus or hyperhomocysteinemia based on animal experiments and human studies. We also briefly summarize the relationship among key signaling mechanisms that contribute to the development of coronary dysfunctions in these disorders, which may help develop new targets for efficient cardiometabolic prevention and treatments.

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Acknowledgments

The authors apologize, because many excellent reviews and studies could not be cited due to space limitation. Support: American Heart Association, Founders Affiliate, 0855910D, NIH PO-1 HL-43023, the Hungarian National Science Research Fund (OTKA) K71591 and K67984, SROP-4.2.1/B-10/2/KONV-2010-0002, SROP-4.2.2.A-11/1/KONV-2012-0024.

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Authors and Affiliations

  1. Department of Pathophysiology and Gerontology, Medical School, J. Szentagothai Res. Centre, University of Pecs, 12. Szigeti Str, 7624, Pecs, Hungary

    Akos Koller & Marta Balasko

  2. Department of Physiology, New York Medical College, Valhalla, NY, USA

    Akos Koller

  3. Vascular Biology Center, Medical College of Georgia, GRU, Augusta, GA, 30912, USA

    Zsolt Bagi

Authors
  1. Akos Koller
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  2. Marta Balasko
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  3. Zsolt Bagi
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Corresponding author

Correspondence to Akos Koller.

Additional information

Submitted to Internal and Emergency Medicine (Official Journal of the Italian Society of Internal Medicine) as Proceedings of the 2013 Tuscany Endocrinology And Metabolism Conference (4–6 April, 2013, Pisa, Italy).

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Koller, A., Balasko, M. & Bagi, Z. Endothelial regulation of coronary microcirculation in health and cardiometabolic diseases. Intern Emerg Med 8 (Suppl 1), 51–54 (2013). https://doi.org/10.1007/s11739-013-0910-5

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  • DOI: https://doi.org/10.1007/s11739-013-0910-5

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