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Chaetomium endophytes: a repository of pharmacologically active metabolites

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Abstract

Fungal endophytes are group of fungi that grow within the plant tissues without causing immediate signs of disease and are abundant and diverse producers of bioactive secondary metabolites. The Chaetomium genus of kingdom fungi is considered to be a rich source of unique bioactive metabolites. These metabolites belong to chemically diverse classes, i.e., chaetoglobosins, xanthones, anthraquinones, chromones, depsidones, terpenoids and steroids. Cheatomium through production of diverse metabolites can be considered as a potential source of antitumor, cytotoxic, antimalarial, antibiotic and enzyme inhibitory lead molecules for drug discovery. This review covers isolation of Cheatomium endophytes, extraction and isolation of metabolites and their biological activities.

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References

  • Abbott SP, Sigler L, McAleer R, McGough DA, Rinaldi MG, Mizell G (1995) Fatal cerebral mycoses caused by the ascomycete Chaetomium strumarium. J Clin Microbiol 33:2692–2698

    CAS  PubMed  PubMed Central  Google Scholar 

  • Abdel-Lateff A (2008) Chaetominedione, a new tyrosine kinase inhibitor isolated from the algicolous marine fungus Chaetomium sp. Tetrahedron Lett 49:6398–6400

    Article  CAS  Google Scholar 

  • Abdel-Motaal FF, Nassar MSM, El-Zayat SA, El-Sayed MA, Ito S-I (2010) Antifungal activity of endophytic fungi isolated from Egyptian henbane (Hyoscyamus muticus L.). Pak J Bot 42:2883–2894

    Google Scholar 

  • Albrectsen BR, Bjorken L, Varad A, Hagner A, Wedin M, Karlsson J, Jansson S (2010) Endophytic fungi in European aspen (Populus tremula) leaves-diversity, detection, and a suggested correlation with herbivory resistance. Fungal Divers 41:17–28

    Article  Google Scholar 

  • Alhamed MFA, Shebany YM (2012) Endophytic Chaetomium globosum enhances maize seedling copper stress tolerance. Plant Biol 14:859–863

    Article  PubMed  CAS  Google Scholar 

  • Aly AH, Debbab A, Edrada-Ebel R, Wray V, Müller WE, Lin W, Ebel R, Proksch P (2009) A new tetrahydrofuran derivative from the endophytic fungus Chaetomium sp. isolated from Otanthus maritimus. Z Naturforsch C 64:350–354

    Article  CAS  PubMed  Google Scholar 

  • Aly AH, Debbab A, Kjer J, Proksch P (2010) Fungal endophytes from higher plants: a profilic source of phytochemicals and other bioactive natural products. Fungal Divers 41:1–16

    Article  Google Scholar 

  • Anita DD, Sridhar KR (2009) Assemblage and diversity of fungi associated with mangrove wild legume Canavalia cathartica. Trop Subtrop Agroecosyst 10:225–235

    Google Scholar 

  • Arnold AE, Engelbrecht BMJ (2007) Fungal endophytes nearly double minimum leaf conductance in seedlings of a neotropical tree species. J Trop Ecol 23:369–372

    Article  Google Scholar 

  • Asgari B, Zare R (2011) The genus Chaetomium in Iran, a phylogenetic study including six new species. Mycologia 103:863–882

    Article  PubMed  Google Scholar 

  • Azevedo JL, Pereira JO, Araújo WL (2000) Endophytic microorganisms: a review on insect control and recent advances on tropical plants. Electron J Biotechnol 3:40–65

    Article  Google Scholar 

  • Bacon CW, White JF (2000) An overview of endophytic microbes: endophytism definition, microbial endophytes. Marcel Dekker, New York, pp 3–5

    Google Scholar 

  • Bagchi B, Banerjee D (2013) Diversity of fungal endophytes in Bauhinia vahlii (A Lianas) from different regions Of Paschim Medinipur District of West Bengal. Int J Sci Environ Technol 2:748–756

    Google Scholar 

  • Barron MA, Sutton DA, Veve R, Guarro J, Rinaldi M, Thompson E, Cagnoni PJ, Moultney K, Madinger NE (2003) Invasive mycotic infections caused by Chaetomium perlucidum, a new agent of cerebral phaeohyphomycosis. J Clin Microbiol 41:5302–5307

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bharat PB, Wijeratne MK, Faeth SH, Gunatilaka AAL (2005) Globosumones A-C, cytotoxic orsellinic acid esters from the Sonoran Desert endophytic fungus Chaetomium globosum. J Nat Prod 68:724–728

    Article  CAS  Google Scholar 

  • Borges WS, Mancilla G, Guimaraes DO, Duran-Patron R, Collado IG, Pupo MT (2011) Azaphilones from the endophyte Chaetomium globosum. J Nat Prod 74:1182–1187

    Article  CAS  PubMed  Google Scholar 

  • Budhiraja AK, Nepali S, Kaul Dhar KL (2012) Antimicrobial and cytotoxic activities of fungal isolates of medicinal plant Gloriosa superba. Int J Recent Adv Pharm Res 2:37–45

    Google Scholar 

  • Budhiraja AK, Nepali S, Kaul Dhar KL (2013) Community analysis of endophytic fungi in medicinal plant Gloriosa superba. Adv Hum Biol 3(1):15–20

    Google Scholar 

  • Cowman AF, Baldi DL, Healer J, Mills KE, O’Donnell RA, Reed MB, Triglia T, Wickham ME, Crabb BS (2000) Functional analysis of proteins involved in Plasmodium falciparum merozoite invasion of red blood cells. FEBS Lett 476:84–88

    Article  CAS  PubMed  Google Scholar 

  • Cui CM, Li XM, Li CS, Proksch P, Wang BG (2010) Cytoglobosins A-G, cytochalasans from a marine-derived endophytic fungus, Chaetomium globosum QEN-14. J Nat Prod 73:729–733

    Article  CAS  PubMed  Google Scholar 

  • Debbab A, Aly AH, Edrada-Ebel RA, Müller WE, Mosaddak M, Hakiki A, Ebel R, Proksch P (2009) Bioactive secondary metabolites from the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco. Biotechnol Agron Soc Environ 13:229–234

    CAS  Google Scholar 

  • Ding G, Song YC, Chen JR, Xu C, Ge HM, Wang XT, Tan RX (2006) Chaetoglobosin U, a cytochalasan alkaloid from endophytic Chaetomium globosum IFB-E019. J Nat Prod 69:302–304

    Article  CAS  PubMed  Google Scholar 

  • Dizdaroglu M, Jaruga P, Birincioglu M, Rodriguez H (2002) Free radical induced damage to DNA: mechanisms and measurement. Free Radic Bio Med 32:1102–1115

    Article  CAS  Google Scholar 

  • El-Zayat SA (2008) Preliminary studies on laccase production by Chaetomium globosum and endophytic fungus in Glinus lotoides. Am Eurasian J Agric Environ Sci 3:86–90

    Google Scholar 

  • Fujimoto H, Nakayama M, Nakayama Y, Yamazaki M (1994) Isolation and characterization of immunosuppressive components of three mushroom, Pisolithus tinctorius, Microporus flabelliformis and Lenzites betulina. Chem Pharm Bull 42:694–697

    Article  CAS  PubMed  Google Scholar 

  • Gangadevi V, Muthumary J (2008) Isolation of Colletotrichum gloeosporioides, a novel endophytic Taxol-producing fungus from Justicia gendarussa. Mycol Balcanica 5:1–4

    Google Scholar 

  • Gangadevi V, Yogeswari S, Kamalraj S, Rani G, Muthumary J (2008) The antibacterial activity of Acalypha indica L. Indian J Sci Technol 1:1–5

    Google Scholar 

  • Gao K, Liu X, Kang Z, Mendgen K (2005) Mycoparasitism of R. solani by endophytic Chaetomium spirale ND35: ultrastructure and cytochemistry of the interaction. J Phytopathol 153:280–290

    Article  Google Scholar 

  • Ge HM, Zhang WY, Ding G, Saparpakorn P, Song YV, Hannongbuac S, Tan RX (2008) Chaetoglobins A and B, two unusual alkaloids from endophytic Chaetomium globosum culturew. Chem Commun:5978–5980

  • Ge HM, Zhang Q, Xu SH, Guo ZK, Song YC, Huang WY, Tan RX (2011) Chaetoglocins A-D, four new metabolites from the endophytic fungus Chaetomium globosum. Planta Med 77:277–280

    Article  CAS  PubMed  Google Scholar 

  • Gehlot P, Bohra NK, Purohit DK (2008) Endophytic mycoflora of inner bark of Prosopis cineraria—a key stone tree species of Indian desert. Am Eur J Bot 1:01–04

    Google Scholar 

  • Gond SK, Verma VC, Kumar A, Kumar V, Kharwar RN (2007) Study of endophytic fungal community from different parts of Aegle marmelos Correa (Rutaceae) from Varanasi (India). World J Microbiol Biol 23:1371–1375

    Article  Google Scholar 

  • Gunatilaka AAL (2006) Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity, and implications of their occurrence. J Nat Prod 69:509–526

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Guo L, Wu JZ, Han T, Cao T, Rahman K, Qin LP (2008) Chemical composition, antifungal and antitumor properties of ether extracts of Scapania verrucosa Heeg and its endophytic fungus Chaetomium fusiforme. Molecules 13:2114–2125

    Article  CAS  PubMed  Google Scholar 

  • Haq IU, Mirza B, Kondratyuk TP, Park EJ, Burns BE, Marler LE, Pezzuto JM (2012) Preliminary evaluation for cancer chemopreventive and cytotoxic potential of naturally growing ethnobotanically selected plants of Pakistan. Pharm Biol 51:316–328

    Article  Google Scholar 

  • Ho M-Y, Chung W-C, Huang H-C, Chung W-H, Chung W-H (2012) Identification of endophytic fungi of medicinal herbs of Lauraceae and Rutaceae with antimicrobial property. Taiwania 57:229–241

    Google Scholar 

  • Huang WY, Cai YZ, Hyde KD, Corke H, Sun M (2007a) Endophytic fungi from Nerium oleander L (Apocynaceae): main constituents and antioxidant activity. World J Microbiol Biotechnol 23:1253–1263

    Article  CAS  Google Scholar 

  • Huang WY, Yi ZC, Xing J, Corke H, Sun M (2007b) Potential antioxidant resource: endophytic fungi from medicinal plants. Econ Bot 61:14–30

    Article  CAS  Google Scholar 

  • Istifadah N, McGee PA (2006) Endophytic Chaetomium globosum reduces development of tan spot in wheat caused by Pyrenophora tritici-repentis. Australas Plant Pathol 35:411–418

    Article  Google Scholar 

  • Jalgaonwala RE, Mohite BV, Mahajan RT (2011) A review: natural products from plant associated endophytic fungi. J Microbiol Biotech Res 1:21–32

    Google Scholar 

  • Jiao RH, Xu S, Liu JY, Ge HM, Ding H, Xu C, Zhu HL, Tan RX (2006) Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015. Org Lett 8:5709–5712

    Article  CAS  PubMed  Google Scholar 

  • Khan R, Shahzad S, Choudhary MI, Khan S, Ahmad A (2010) Communities of endophytic fungi in medicinal plant Withania somnifera. Pak J Bot 42:1281–1287

    Google Scholar 

  • Khan AL, Shinwari ZK, Kim Y, Waqas M, Hamayun M, Kamran M, Lee I (2012) Isolation and detection of Gibberellins and indole acetic acid from Endophyte Chaetomium globosum LK4 growing with drought stressed plant. Pak J Bot 44:1601–1607

    Google Scholar 

  • Kobayashi H, Namikoshi M, Yoshimoto T, Yokochi T (1996) A screening method for antimitotic and antifungal substances using conidia of Pyricularia oryzae, modifications and application to tropical marine fungi. J Antibiot 49:873–879

    Article  CAS  PubMed  Google Scholar 

  • Koyama K, Akiba M, Imaizumi T, Kinoshita K, Takahashi K, Suzuki A, Yano S, Horie S, Watanabe K (2002) Antinociceptive constituents of Auricularia polytricha. Planta Med 68:284–285

    Article  CAS  PubMed  Google Scholar 

  • Krishnamurthy YL, Shankar NB, Shashikala J (2008) Fungal communities in herbaceous medicinal plants, Malnad region, Southern India. Microbes Environ 23:24–28

    Article  PubMed  Google Scholar 

  • Krishnamurthy YL, Shashikala J, Shankarnaik B (2009) Diversity and seasonal variation of endophytic fungal communities associated with some medicinal trees of Western Ghats, Southern India. Sydowia 61:255–266

    Google Scholar 

  • Kumar S, Kaushik N (2013) Endophytic fungi isolated from oil-seed crop Jatropha curcas produces oil and exhibit antifungal activity. PLoS One 8:e56202. doi:10.1371/journal.pone.0056202

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kumar S, Sharma S, Pathak DV, Beniwal J (2011) Integrated management of Jatropha root rot caused by Rhizoctonia bataticola. J Trop For Sci 23:35–41

    Google Scholar 

  • Kumar S, Kaushik N, Proksch P (2013) Identification of antifungal principle in the solvent extract of an endophytic fungus Chaetomium globosum from Withania somnifera. Springer Plus 2:37

    Article  PubMed  PubMed Central  Google Scholar 

  • Leite TDE, Cnossen-Fassoni A, Pereira OL, Mizubuti ESG, Araújo EFD, Queiroz MVD (2013) Novel and highly diverse fungal endophytes in soybean revealed by the consortium of two different techniques. J Microbiol 51:56–69

    Article  CAS  Google Scholar 

  • Li GY, Li BG, Yang T, Liu GY, Zhang GL (2008) Secondary metabolites from the fungus Chaetomium brasiliense. Helv Chim Acta 91:124–129

    Article  CAS  Google Scholar 

  • Li HQ, Li XJ, Wang YL, Zhang Q, Zhang AL, Gao JM, Zhang XC (2011) Antifungal metabolites from Chaetomium globosum, an endophytic fungus in Ginkgo biloba. Biochem Syst Ecol 39:876–879

    Article  CAS  Google Scholar 

  • Li X, Tian Y, Yang SX, Zhang YM, Qin JC (2013) Cytotoxic azaphilone alkaloids from Chaetomium globosum TY1. Bioorg Med Chem Lett 23:2945–2947

    Article  CAS  PubMed  Google Scholar 

  • Li H, Xiao J, Gao YQ, Tang JJ, Zhang AL, Gao JM (2014) Chaetoglobosins from Chaetomium globosum, an endophytic fungus in Ginkgo biloba, and their phytotoxic and cytotoxic activities. J Agric Food Chem 62:3734–3741

    Article  CAS  PubMed  Google Scholar 

  • Lu Y, Chen S, Wang B (2009) Cytotoxic activities of endophytic fungi isolated from the endangered, Chinese endemic species Dysosma pleiantha. Z Naturforsch 64c:518–520

    Google Scholar 

  • Lu K, Zhang Y, Li L, Wang X, Ding G (2013) Chaetochromones A and B, two new polyketides from the fungus Chaetomium indicum (CBS.860.68). Molecules 18:10944–10952

    Article  CAS  PubMed  Google Scholar 

  • Mao BZ, Huang C, Yang GM, Chen YZ, Chen SY (2010) Separation and determination of the bioactivity of oosporein from Chaetomium cupreum. Afr J Biotechnol 9:5955–5961

    CAS  Google Scholar 

  • Márquez SS, Bills GF, Zabalgogeazcoa I (2007) The endophytic mycobiota of the grass Dactylis glomerata. Fungal Divers 27:171–195

    Google Scholar 

  • Millner PD (1977) Radial growth responses to temperature by 58 Chaetomium species, and some taxonomic relationships. Mycologia 69:492–502

    Article  Google Scholar 

  • Momesso LDS, Kawano CY, Ribeiro PH, Nomizo A, Goldman G, Pupo MT (2008) Chaetoglobosins produced by Chaetomium globosum, endophytic fungus found in association with Viguiera robusta Gardn (Asteraceae). Quim Nova 31:1680–1685

    Article  CAS  Google Scholar 

  • Na YJ, Jeon YJ, Suh JH, Kang JS, Yang KH, Kim HM (2001) Suppression of IL-8 gene expression by radicicol is mediated through the inhibition of ERK1/2 and p38 signaling and negative regulation of NF-kappa B and AP-1. Int Immunopharmacol 1:1877–1887

    Article  CAS  PubMed  Google Scholar 

  • Naik BS, Shashikala J, Krishnamurthy YL (2008) Diversity of fungal endophytes in shruby medicinal plants of Malnad region, Western Ghats, Southern India. Fungal Ecol 1:89–93

    Article  Google Scholar 

  • Naik BS, Shashikala J, Krishnamurthy YL (2009) Study on the diversity of endophytic communities from rice (Oryza sativa L.) and their antagonistic activities in vitro. Microbiol Res 164:290–296

    Article  CAS  PubMed  Google Scholar 

  • Nalini MS, Mahesh B, Tejesvi MV, Prakash HS, Subbaiah V, Kini KR, Shetty HS (2005) Fungal endophytes from the three leaved caper, Crataeva magna (Lour.) (Capparidaceae). Mycopathologia 159:245–249

    Article  PubMed  Google Scholar 

  • Neda H, Halasz K, Posa T, Peter G, Hrotko K, Gaspar L, Lukacs N (2011) Diversity of endophytic fungi isolated from cherry (Prunus avium). J Hortic For Biotech 15:1–6

    Google Scholar 

  • Ni ZW, Li GH, Zhao PJ, Shen YM (2008) Antimicrobial components of the endophytic fungal strain Chaetomium globosum Ly50′ from Maytenus hookeri. Nat Prod Res Dev 20:33–36

    CAS  Google Scholar 

  • Nunez-Trujillo G, Cabrera R, Burgos-Reyes RL, Da Silva E, Gimenez C, Cosoveanu A, Brito N (2012) Endophytic fungi from Vitis vinifera L. isolated in Canary Islands and Azores as potential biocontrol agents of Botrytis cinerea Pers. J Hortic For Biotech 16:1–6

    Google Scholar 

  • Park JH, Choi GJ, Jang KS, Lim HK, Kim HT, Cho KY, Kim JC (2005) Antifungal activity against plant pathogenic fungi of chaetoviridins isolated from Chaetomium globosum. FEMS Microbiol Lett 252:309–313

    Article  CAS  PubMed  Google Scholar 

  • Peng W, Guo L, Zheng CJ, Zhang QY, Jia M, Jiang YP, Han T, Qin LP (2012) Two new azaphilone alkaloids dimers from endophyte Chaetomium fusiforme of the liverwort Scapania verrucosa Heeg. Biochem Syst Ecol 45:124–126

    Article  CAS  Google Scholar 

  • Pimentel MR, Molina G, Dionisio PA, Marostica Junior MR, Pastore GM (2010) The use of endophytes to obtain bioactive compounds and their application in biotransformation process: review article. Biotechnol Res Int 2011:1–11. doi:10.4061/2011/576286

    Article  CAS  Google Scholar 

  • Pontius A, Krick A, Kehraus S, Brun R, König GM (2008) Antiprotozoal activities of heterocyclic-substituted xanthones from the marine-derived fungus Chaetomium sp. J Nat Prod 71:1579–1584

    Article  CAS  PubMed  Google Scholar 

  • Qin JC, Zhang YM, Gao JM, Bai MS, Yang SX, Laatsch H, Zhang AL (2009a) Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba. Bioorg Med Chem Lett 19:1572–1574

    Article  CAS  PubMed  Google Scholar 

  • Qin JC, Bai L, Li XM, Zhang YM, Gao JM, Laatsch H (2009b) Polyhydroxylated steroids from an endophytic fungus, Chaetomium globosum ZY-22 isolated from Ginkgo biloba. Steroids 74:786–790

    Article  CAS  PubMed  Google Scholar 

  • Qin JC, Bai L, Li XM, Zhang YM, Gao JM, Laatsch H (2009c) Isolation and identification of the metabolites produced by an endophytic fungus Chaetomium globosum ZY-22 from Ginkgo biloba. Acta Bot Boreal Occident Sin 29:1264–1268

    CAS  Google Scholar 

  • Qiu ZY, Yi ZR, Rui M, Qiong TZ, Jie WY (2009) Endophytic fungi of roots of Eulophia flava. Southwest China J Agric Sci 22:675–680

    Google Scholar 

  • Rajagopal K, Kalavathy S, Kokila S, Karthikeyan S, Kathiravan G, Prasad R, Balasubraminan P (2010) Diversity of fungal endophytes in few medicinal herbs of South India. Asian J Exp Biol Sci 1:415–418

    Google Scholar 

  • Ramesh A, Srinivas C (2014) Antimicrobial activity and phytochemical analysis of crude extracts of endophytic fungi isolated from Plumeria acuminata L. and Plumeria obtusifolia L. Eur J Exp Biol 4:35–43

    Google Scholar 

  • Ravindran C, Naveenan T, Varatharjan GR (2010) Optimization of alkaline cellulase production by marine derived fungus Chaetomium sp., using agricultural and industrial wastes as substrates. Bot Mar 53:275–282

    Article  CAS  Google Scholar 

  • Ravindran C, Naveenan T, Varatharajan GR, Rajasabapathy R, Meena RM (2012) Antioxidants in mangrove plants and endophytic fungal associations. Bot Mar 55:269–279

    Article  CAS  Google Scholar 

  • Rodrigues KF, Costa GL, Carvalho MP, Epifanio RDA (2005) Evaluation of extracts produced by some tropical fungi as potential cholinesterase inhibitors. World J Microbiol Biotechnol 21:1617–1621

    Article  Google Scholar 

  • Sadrati N, Duoud H, Zerroug A, Duhamna S, Bouharati S (2013) Screening of antimicrobial and antioxidant secondary metabolites from endophytic fungi isolated from wheat (Triticum durum). J Plant Prot Res 53:128–136

    Article  Google Scholar 

  • Sagar A, Thakur S (2009) Studies on fungal associates of Aloe vera Linn., and Mentha viridis L. Plant Arch 9:369–374

    Google Scholar 

  • Samson RA, Hoekstra ES, Frisvad JC, Filtenborg O (1984) Introduction to food and airborne fungi, Centraalbureau Voor Schimmelcultures, 6th edition. Institute of the Royal Netherlands Academy of Arts and Sciences, Utrecht, 2000

  • Sawmya K, Vasudevan TG, Murali TS (2013) Fungal endophytes from two orchid species pointer towards organ specificity. Czech Mycol 65:89–101

    Google Scholar 

  • Schlörke O, Zeeck A (2006) Orsellides A–E: an example for 6-deoxyhexose derivatives produced by fungi. Eur J Org Chem 2006(4):1043–1049

    Article  CAS  Google Scholar 

  • Schomburg I, Chang A, Placzek S, Söhngen C, Rother M, Lang Munaretto C, Ulas S, Stelzer M, Grote A, Scheer M, Schomburg D (2013) BRENDA in 2013: integrated reactions, kinetic data, enzyme function data, improved disease classification: new options and contents in BRENDA. Nucleic Acids Res 41:764–772

    Article  CAS  Google Scholar 

  • Selim KA, El-Beih AA, Abdel-Rahman TM, El-Diwany A (2014) Biological evaluation of endophytic fungus, Chaetomium globosum J N711454, as potential candidate for improving drug discovery. Cell Biochem Biophys 68:67–82

    Article  CAS  PubMed  Google Scholar 

  • Shankar NB, Shashikala J (2010) Diversity and structure of fungal endophytes in some climbers and grass species of Malnad region, Western Ghats, Southern India. Mycosphere 1940:265–274

    Google Scholar 

  • Sharma R, Kulkarni G, Sonawane MS, Shouche YS (2013) A new endophytic species of Chaetomium from Jatropha podagrica. Mycotaxon 124:117–126

    Article  Google Scholar 

  • Srimathi S, Narayani DSK, Muthumary J (2011) Studies on antimicrobial activities of Chaetomium atrobrunneum Ames against selected microorganisms. J Exper Sci 2:13–18

    CAS  Google Scholar 

  • Strobel GA (2003) Endophytes as source of bioactive products. Microbiol Infect 5:535–544

    Article  CAS  Google Scholar 

  • Strobel G, Daisy B (2003) Bioprospecting for microbial endophytes and their natural products. Microbiol Mol Biol Rev 67:491–502

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Talontsi MF, Douanla-Meli C, Laatsch H (2013) Depsidones from an endophytic fungus Chaetomium sp. associated with Zanthoxylum leprieurii. Z Naturforsch 68:1259–1264

    Article  CAS  Google Scholar 

  • Tan RX, Zou WX (2001) Endophytes: a rich source of functional metabolites. Nat Prod Rep 18:448–459

    Article  CAS  PubMed  Google Scholar 

  • Tayung K, Jha DK (2010) Antimicrobial evaluation of some fungal endophytes isolated from bark of Himalayan yew. World J Agric Sci 2:489

    Google Scholar 

  • Tintjer T, Rudger AJ (2006) Grass-herbivore interaction altered by strains of a native endophyte. New Phytol 170:513–521

    Article  PubMed  Google Scholar 

  • Tuppad DS, Shishupala S (2013) Endophytic mycobiota of medicinal plant Butea monosperma. Int J Curr Microbiol Appl Sci 2:615–627

    Google Scholar 

  • Turbyville TJ, Wijeratne EM, Liu MX, Burns AM, Seliga CJ, Luevano LA, David CL, Faeth SH, Whitesell L, Gunatilaka AAL (2006) Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. J Nat Prod 69:178–184

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Udagawa T, Yuan J, Panigrahy D, Chang YH, Shah J, D’Amato RJ (2000) Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. J Pharmacol Exp Ther 294:421–427

    CAS  PubMed  Google Scholar 

  • Valko M, Izakovic M, Mazur M, Rhodes CJ, Telser J (2004) Roleofoxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem 266:37–56

    Article  CAS  PubMed  Google Scholar 

  • Vial H, Taramelli D, Boulton IC, Ward SA, Doerig C, Chibale K (2013) CRIMALDDI: platform technologies and novel antimalarial drug targets. Malaria J 12:396

    Article  Google Scholar 

  • Violi HA, Menge JA, Beaver RJ (2007) Chaetomium elatum (Kunze: Chaetomiaceae) as a root-colonizing fungus in avocado: is it a mutualist, cheater, commensalistic associate, or pathogen? Am J Bot 94:690–700

    Article  PubMed  Google Scholar 

  • Von Arx JA, Guarro J, Figueras MJ (1986) The ascomycete genus Chaetomium. Beih Nova Hedw 84:1–162

    Google Scholar 

  • Wang S, Li XM, Teuscher F, Li DL, Diesel A, Ebel R, Proksch P, Wang BG (2006) Chaetopyranin, a benzaldehyde derivative, and other related metabolites from Chaetomium globosum, an endophytic fungus derived from the marine red alga Polysiphoniaur ceolata. J Nat Prod 69:1622–1625

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Xu L, Ren W, Zhao D, Zhu Y, Wu X (2012) Bioactive metabolites from Chaetomium globosum L18, an endophytic fungus in the medicinal plant Curcuma wenyujin. Phytomedicine 15:364–368

    Article  CAS  Google Scholar 

  • Wijeratne EMK, Turbyville TJ, Fritz A, Whitesell L, Gunatilaka AAL (2006) A new dihydroxanthenone from a plant associated strain of the fungus Chaetomium globosum demonstrates anticancer activity. Bioorg Med Chem 14:7917–7923

    Article  CAS  PubMed  Google Scholar 

  • Wu J-G, Peng W, Zeng P-Y, Wu Y-B, Yi J, Wu J-Z (2013) Antimicrobial activity and cytotoxicity of endophytes from Scapania verrucosa Heeg. Genet Mol Res 12:916–924

    Article  PubMed  Google Scholar 

  • Xue M, Zhang Q, Gao JM, Li H, Tian JM, Pescitelli G (2012) Chaetoglobosin Vb from endophytic Chaetomium globosum: absolute configuration of chaetoglobosins. Chirality 24:668–674

    Article  CAS  PubMed  Google Scholar 

  • Yadav M, Yadav A, Yadav JP (2014) In vitro antioxidant activity and total phenolic content of endophytic fungi isolated from Eugenia jambolana Lam. Asian Pac J Trop Biomed 4:S648–S653

    Article  Google Scholar 

  • Yamada T, Doi M, Shigeta H, Muroga Y, Hosoe S, Numata A, Tanaka R (2008) Absolute stereostructures of cytotoxic metabolites, chaetomugilins A-C, produced by a Chaetomium species separated from a marine fish. Tetrahedron Lett 49:4192–4195

    Article  CAS  Google Scholar 

  • Yamada T, Yasuhide M, Shigeta H, Numata A, Tanaka R (2009) Absolute stereostructures of chaetomugilins G and H produced by amarine-fish-derived Chaetomium species. J Antibiot 62:353–357

    Article  CAS  PubMed  Google Scholar 

  • Yamada T, Muroga Y, Jinno M, Kajimoto T, Usami Y, Numata A, Tanaka R (2011) New class azaphilone produced by a marine fish-derived Chaetomium globosum. The stereochemistry and biological activities. Bioorg Med Chem 19:4106–4113

    Article  CAS  PubMed  Google Scholar 

  • Yang SW, Mierzwa R, Terracciano J, Patel M, Gullo V, Wagner N, Baroudy B, Puar M, Chan TM, McPhail AT, Chu M (2006) Chemokine receptor CCR-5 inhibitors produced by Chaetomium globosum. J Nat Prod 69:1025–1028

    Article  CAS  PubMed  Google Scholar 

  • Yang SW, Mierzwa R, Terracciano J, Patel M, Gullo V, Wagner N, Baroudy B, Puar M, Chan TM, Chu M (2007) Sch 213766, a novel chemokine receptor CCR-5 inhibitor from Chaetomium globosum. J Antibiot 60:524–528

    Article  CAS  PubMed  Google Scholar 

  • Yasuhide M, Yamada T, Numata A, Tanaka R (2008) Chaetomugilins, new selectively cytotoxic metabolites, produced by a marine fish derived Chaetomium species. J Antibiot 61:615–622

    Article  CAS  PubMed  Google Scholar 

  • Ye Y, Xiao Y, Ma L, Li H, Xie Z, Wang M, Ma H, Tang H, Liu J (2013) Flavipin in Chaetomium globosum CDW7, an endophytic fungus from Ginkgo biloba, contributes to antioxidant activity. Appl Microbiol Biotechnol 97:7131–7139

    Article  CAS  PubMed  Google Scholar 

  • Yu H, Zhang L, Li L, Zheng C, Guo L, Li W, Sun P, Qin L (2010) Recent developments and future prospects of antimicrobial metabolites produced by endophytes. Microbiol Res 165:437–449

    Article  CAS  PubMed  Google Scholar 

  • Zhang HW, Song YC, Tan RX (2006) Biology and chemistry of endophytes. Nat Pro Rep 23:753–771

    Article  CAS  Google Scholar 

  • Zhang J, Ge HM, Jiao RH, Li J, Peng H, Wang YR, Wu JH, Song YC, Tan RX (2010) Cytotoxic chaetoglobosins from the endophyte Chaetomium globosum. Planta Med 76:1910–1914

    Article  CAS  PubMed  Google Scholar 

  • Zhang Q, Li HQ, Zong SC, Gao JM, Zhang AL (2012) Chemical and bioactive diversities of the genus Chaetomium secondary metabolites. Mini Rev Med Chem 12:127–148

    Article  PubMed  Google Scholar 

  • Zhang CY, Ji X, Gui X, Huang BK (2013a) Chemical constituents from an endophytic fungus Chaetomium globosum Z1. Nat Prod Comm 8:1217–1218

    CAS  Google Scholar 

  • Zhang G, Wang F, Qin J, Wang D, Zhang J, Zhang Y, Zhang S, Pan H (2013b) Efficacy assessment of antifungal metabolites from Chaetomium globosum no. 05, a new biocontrol agent against Setosphaeria turcica. Biol Control 64:90–98

    Article  CAS  Google Scholar 

  • Zhao T, Ding K, Zhang L, Cheng XM, Wang CH, Wang ZT (2013) Acetylcholinesterase and butyrylcholinesterase inhibitory activities of β-carboline and quinoline alkaloids derivatives from the plants of genus Peganum. J Chem. doi:10.1155/2013/717232

    Google Scholar 

  • Zheng QC, Kong MZ, Zhao Q, Chen DG, Tian YH, Li XX, Guo DL, Li J, Zheng ZY, Gao H (2014) Chaetoglobosin Y, a new cytochalasan from Chaetomium globosum. Fitoterapia 93:126–131

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, 22060, Pakistan

    Nighat Fatima & Tariq Ismail

  2. Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan

    Syed Aun Muhammad

  3. UNESCO Chinese Center of Marine Biotechnology, Ocean University of China, Qingdao, China

    Ibrar Khan

  4. Department of Microbiology, Shah Abdul Latif University, Khairpur, Sindh, 66020, Pakistan

    Muneer Ahmed Qazi

  5. Department of Environmental Sciences, COMSATS Institute of Information Technology, Abbottabad, 22060, Pakistan

    Irum Shahzadi

  6. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, 22060, Pakistan

    Amara Mumtaz, Muhammad Ali Hashmi & Abida Kalsoom Khan

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  1. Nighat Fatima
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  2. Syed Aun Muhammad
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  3. Ibrar Khan
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Correspondence to Nighat Fatima.

Additional information

Communicated by A. K. Kononowicz.

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Fatima, N., Muhammad, S.A., Khan, I. et al. Chaetomium endophytes: a repository of pharmacologically active metabolites. Acta Physiol Plant 38, 136 (2016). https://doi.org/10.1007/s11738-016-2138-2

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  • DOI: https://doi.org/10.1007/s11738-016-2138-2

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