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Layered double hydroxide using hydrothermal treatment: morphology evolution, intercalation and release kinetics of diclofenac sodium

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Abstract

The present work demonstrates the possibilities of hydrothermal transformation of Zn-Al layered double hydroxide (LDH) nanostructure by varying the synthetic conditions. The manipulation in washing step before hydrothermal treatment allows control over crystal morphologies, size and stability of their aqueous solutions. We examined the crystal growth process in the presence and the absence of extra ions during hydrothermal treatment and its dependence on the drug (diclofenac sodium (Dic-Na)) loading and release processes. Hexagonal plate-like crystals show sustained release with ∼90% of the drug from the matrix in a week, suggesting the applicability of LDH nanohybrids in sustained drug delivery systems. The fits to the release kinetics data indicated the drug release as a diffusion-controlled release process. LDH with rod-like morphology shows excellent colloidal stability in aqueous suspension, as studied by photon correlation spectroscopy.

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Acknowledgements

The authors are grateful to the Director, Central Glass & Ceramic Research Institute, Kolkata for permission and extending facilities to carry out the above work. MJ and SJI acknowledge UGC and CSIR for their fellowships. We thank 12 FYP CSIR Network project ESC-0103 for funding the DLS facility. Staff members of electron microscopy, XRD, FTIR and Central Instrumentation Facility are also acknowledged for their assistance in obtaining data.

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Authors and Affiliations

  1. Project Management Division, CSIR-Central Glass & Ceramic Research Institute, Kolkata, 700032, India

    Mathew Joy, Srividhya J. Iyengar & Swapankumar Ghosh

  2. Bioceramics & Coating Division, CSIR-Central Glass & Ceramic Research Institute, Kolkata, 700032, India

    Mathew Joy, Srividhya J. Iyengar & Jui Chakraborty

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  1. Mathew Joy
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  2. Srividhya J. Iyengar
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  4. Swapankumar Ghosh
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Correspondence to Mathew Joy or Swapankumar Ghosh.

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Joy, M., Iyengar, S.J., Chakraborty, J. et al. Layered double hydroxide using hydrothermal treatment: morphology evolution, intercalation and release kinetics of diclofenac sodium. Front. Mater. Sci. 11, 395–408 (2017). https://doi.org/10.1007/s11706-017-0400-1

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