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Synthesis of copper–nitrogen codoped carbon quantum dots using frangipani as a carbon source and application of metronidazole determination

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Abstract

High-fluorescence Cu/N-codoped carbon quantum dots (Cu/NCQDs) were prepared by a one-step hydrothermal method using frangipani and copper acetate hydrate. The prepared Cu/NCQDs exhibited a nearly spherical morphology, and the average particle size was 2.58 nm. The surface of the Cu/NCQDs contains abundant hydrophilic groups –OH, –NH2 and –COOH, which explains their high water solubility. The Cu/NCQDs exhibited high-intensity, stable blue fluorescence that is independent of the excitation wavelength. As metronidazole can effectively quench the fluorescence intensity of Cu/NCQDs, a metronidazole fluorescence-detection method using Cu/NCQDs as the fluorescence probe was developed, and the quenching mechanism was studied. The method has the advantages of simplicity, speed, and low cost. Besides, the linear equation was F =  − 3.235 + 9.064 C(MNZ)(μmol/L), the correlation coefficient (R2) was 0.996, and the detection limit was 0.28 μmol/L. Further, the metronidazole content in actual samples was determined using this method; the recovery rates of the metronidazole tablets and honey samples were 96.8–103.7%, and relative standard deviation was lower than 6%.

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Acknowledgments

This research was supported by Opening project of Guangxi Key Laboratory of Calcium Carbonate Resources Comprehensive Utilization No. HZXYKFKT201907.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, China

    Yuwei Lan, Wenbin Bao, Chunfeng Liang, Guowei Li, Liya Zhou, Jiachu Yang, Liubai Wei & Qionghua Su

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  1. Yuwei Lan
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  2. Wenbin Bao
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  3. Chunfeng Liang
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  4. Guowei Li
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  5. Liya Zhou
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Correspondence to Yuwei Lan.

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Lan, Y., Bao, W., Liang, C. et al. Synthesis of copper–nitrogen codoped carbon quantum dots using frangipani as a carbon source and application of metronidazole determination. Chem. Pap. 77, 1005–1015 (2023). https://doi.org/10.1007/s11696-022-02487-4

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