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Mesoporous nanocarriers with cyclic peptide gatekeeper containing N-cadherin binding sequence for stimulus-responsive drug release

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Abstract

Various peptides have been used extensively to prepare selective drug delivery carriers due to the ability to target specific cells and to be selectively degraded by various biostimulants. Furthermore, nanocarriers capable of controlled drug release could be prepared by employing the triggered conformational transformation of peptides by specific biostimulation. Here, a cyclic peptide gatekeeper with an HAV sequence, known to specifically bind to N-cadherin, is introduced on the surface of mesoporous nanocarriers. The drug release from the nanocarriers is completely inhibited in the absence of external stimuli. In the presence of specific biostimuli, the cyclic peptide gatekeeper is transformed, and the encapsulated drugs in the nanocarriers are released on demand.

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Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF-2021R1C1C2011651). C.K thanks Inha University for support.

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Authors and Affiliations

  1. Department of Polymer Science and Engineering, Inha University, Incheon, 22212, Korea

    Jeonghun Lee & Chulhee Kim

  2. Program in Environmental and Polymer Engineering, Inha University, Incheon, 22212, Korea

    Kitae Kim & Chulhee Kim

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  1. Jeonghun Lee
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  2. Kitae Kim
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  3. Chulhee Kim
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Correspondence to Chulhee Kim.

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Lee, J., Kim, K. & Kim, C. Mesoporous nanocarriers with cyclic peptide gatekeeper containing N-cadherin binding sequence for stimulus-responsive drug release. Chem. Pap. 76, 6801–6807 (2022). https://doi.org/10.1007/s11696-022-02367-x

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  • DOI: https://doi.org/10.1007/s11696-022-02367-x

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