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Improvement of Triglyceride–Glucose Index Following Bariatric Surgery: a Systematic Review and Meta-analysis

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Abstract

Background

Bariatric surgery is an effective intervention for the management of severe obesity and its associated comorbidities, including metabolic abnormalities. This meta-analysis aimed to evaluate the impact of bariatric surgery on the triglyceride-glucose (TyG) index, a novel marker of insulin resistance and metabolic syndrome.

Methods

A systematic search was conducted in Embase, PubMed, Web of Science, and Scopus. The meta-analysis was performed using Comprehensive Meta-Analysis (CMA) V4 software. The overall effect size was determined by a random-effects meta-analysis and the leave-one-out approach.

Results

A total of 9 trials including 1620 individuals confirmed a significant reduction in TyG following bariatric surgery (weighted mean difference (WMD) − 0.770, 95% CI − 1.006, − 0.534, p < 0.001). In a sub-analysis according to the type of bariatric surgery there was a significant reduction in TyG index for Roux-en-Y gastric bypass (WMD − 0.775, 95% CI − 1.000, − 0.550, p < 0.001), and sleeve gastrectomy (WMD − 0.920, 95% CI − 1.368, − 0.473, p < 0.001). In a sub-analysis according to the follow-up duration there was similarly a significant reduction in TyG index for both < 12 months (WMD − 1.645, 95% CI − 2.123, − 1.167, p < 0.001), and ≥ 12 months follow-up (WMD − 0.954, 95% CI − 1.606, − 0.303, p < 0.001).

Conclusion

The results of this meta-analysis demonstrated a significant reduction in the TyG index following bariatric surgery, indicating improved insulin sensitivity and metabolic health. These findings highlight the potential of bariatric surgery as a valuable therapeutic option for individuals with obesity and its metabolic consequences.

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Data Availability

The datasets generated and/or analysed during the current study are not publicly available but are available from the corresponding author on reasonable request.

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Funding

This work was supported by the Russian Science Foundation (Grant # 23–65-10014).

Author information

Authors and Affiliations

  1. Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Tannaz Jamialahamdi

  2. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran

    Tannaz Jamialahamdi

  3. Department of Surgery, University of California Irvine Medical Center, Orange, CA, USA

    Kishore M. Gadde & Ninh T. Nguyen

  4. Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA

    Matthew Kroh

  5. Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, Moscow, 125315, Russia

    Vasily N. Sukhorukov

  6. Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates

    Wael Almahmeed

  7. Medical Research Centre, Sultan Qaboos University, Muscat, Oman

    Khalid Al-Rasadi

  8. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  9. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

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  1. Tannaz Jamialahamdi
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Key Points

• Bariatric surgery is an effective for the management of severe obesity and its associated comorbidities.

• The results of this meta-analysis demonstrated a significant reduction in the TyG index following bariatric surgery.

• The results indicated improved insulin sensitivity and metabolic health.

• These findings highlight the potential of bariatric surgery as a valuable therapeutic option for individuals with obesity and its metabolic consequences.

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Jamialahamdi, T., Gadde, K.M., Nguyen, N.T. et al. Improvement of Triglyceride–Glucose Index Following Bariatric Surgery: a Systematic Review and Meta-analysis. OBES SURG 34, 741–750 (2024). https://doi.org/10.1007/s11695-023-06992-7

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  • DOI: https://doi.org/10.1007/s11695-023-06992-7

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