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Evaluation of all Types of Metabolic Bariatric Surgery and its Consequences: a Systematic Review and Meta-Analysis

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Abstract

Background

Considering conflicting results on the consequences of all types of obesity surgery, we were to summarize them via a systematic review.

Methods

Electronic literature search was done via scientific search engines. After the removal of duplicates and selection of articles of interest, 771 studies were included.

Results

Insulin resistance indicators were significantly improved after bariatric surgery. Leptin was also significantly decreased while adiponectin was significantly increased. Although the level of metabolic hormones changed after bariatric surgery, they were not statistically significant. Inflammation indicators were significantly decreased. Significant reduction was also detected in PAI-1 and sICAM-1.

Conclusions

Bariatric surgery is beneficial in morbidly obese patients. Although treating obesity in a surgical way may cause some complications, the weight loss is generally safe and effective.

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Acknowledgements

Research reported in this publication was supported by the Elite Researcher Grant Committee under award number 958714 from the National Institutes for Medical Research Development (NIMAD), Tehran, Iran.

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Authors and Affiliations

  1. Medical Student, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Matin Khosravi-Largani

  2. Department of Community and Family Medicine, Preventive Medicine & Public Health Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Marzieh Nojomi

  3. Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran

    Rokhsareh Aghili

  4. Trauma and Injury Research Center, Iran University of Medical Sciences, Tehran, Iran

    Hamidreza Alizadeh Otaghvar

  5. Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

    Kiarash Tanha

  6. Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology & Metabolism, Iran University of Medical Sciences, Tehran, Iran

    Seyyed Hashem Sezavar Seyedi & Azadeh Mottaghi

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  1. Matin Khosravi-Largani
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Correspondence to Azadeh Mottaghi.

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Author 2 reports grants from National Institutes for Medical Research Development (NIMAD), during the conduct of the study. All of the other authors report no conflict of interest.

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Khosravi-Largani, M., Nojomi, M., Aghili, R. et al. Evaluation of all Types of Metabolic Bariatric Surgery and its Consequences: a Systematic Review and Meta-Analysis. OBES SURG 29, 651–690 (2019). https://doi.org/10.1007/s11695-018-3550-z

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