Abstract
Bariatric surgery (BS) is escalating as the most efficient and endurable therapy for severe obesity. Women’s reproductive health is essential to women’s quality of life and is receiving increasing attention. However, despite the high prevalence of BS among women, the effect of BS on reproductive health remains underemphasis. The purpose of this narrative review is to provide an overview of BS on women’s reproductive health, including their reproductive health before, during, and after pregnancy. Although limited attention has been given, current evidence highlights the substantial implications of bariatric surgery on reproductive health and reminds us of the importance of adopting decision-making conversations about reproductive health before bariatric surgery.
Similar content being viewed by others
References
Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in China. Lancet Diabetes Endocrinol. 2021;9(6):373–92.
Al-Najim W, Docherty NG, le Roux CW. Food intake and eating behavior after bariatric surgery. Physiol Rev. 2018;98(3):1113–41.
Sweet L, Vasilevski V. Women’s experiences of pregnancy and lactation after bariatric surgery: a scoping review. Midwifery. 2022;110:103338.
Thies-Lagergren L, Martensson A, Safi A. Women’s experiences of pregnancy after gastric bypass surgery. Eur J Midwifery. 2022;6:52.
Goldenshluger A, Elazary R, Ben Porat T, et al. Knowledge, attitudes, and behaviors of women during pregnancy after bariatric surgery. Surg Obes Relat Dis. 2020;16(7):925–30.
Ben Porat T, Yuval JB, Elchalal U, et al. Reproductive health counseling, attitudes, and practices: a cross-sectional survey among bariatric surgeons. Surg Obes Relat Dis. 2019;15(12):2101–6.
Gronroos S, Helmio M, Juuti A, et al. Effect of laparoscopic sleeve gastrectomy vs Roux-en-Y gastric bypass on weight loss and quality of life at 7 years in patients with morbid obesity: the SLEEVEPASS randomized clinical trial. JAMA Surg. 2021;156(2):137–46.
Aminian A, Wilson R, Al-Kurd A, et al. Association of bariatric surgery with cancer risk and mortality in adults with obesity. JAMA. 2022;327(24):2423–33.
Mentias A, Aminian A, Youssef D, et al. Long-term cardiovascular outcomes after bariatric surgery in the Medicare population. J Am Coll Cardiol. 2022;79(15):1429–37.
Arterburn DE, Telem DA, Kushner RF, Courcoulas AP. Benefits and risks of bariatric surgery in adults: a review. JAMA. 2020;324(9):879–87.
Chen X, Xiao Z, Cai Y, et al. Hypothalamic mechanisms of obesity-associated disturbance of hypothalamic-pituitary-ovarian axis. Trends Endocrinol Metab. 2022;33(3):206–17.
Hoek A, Wang Z, van Oers AM, et al Effects of preconception weight loss after lifestyle intervention on fertility outcomes and pregnancy complications. Fertil Steril. 2022;118(3):456–62.
Escobar-Morreale HF, Santacruz E, Luque-Ramirez M, et al. Prevalence of “obesity-associated gonadal dysfunction” in severely obese men and women and its resolution after bariatric surgery: a systematic review and meta-analysis. Hum Reprod Update. 2017;23(4):390–408.
Lv B, Xing C, He B. Effects of bariatric surgery on the menstruation- and reproductive-related hormones of women with obesity without polycystic ovary syndrome: a systematic review and meta-analysis. Surg Obes Relat Dis. 2022;18(1):148–60.
Di Carlo C, Palomba S, De Fazio M, et al. Hypogonadotropic hypogonadism in obese women after biliopancreatic diversion. Fertil Steril. 1999;72(5):905–9.
Steffen KJ, King WC, White GE, et al. Sexual functioning of men and women with severe obesity before bariatric surgery. Surg Obes Relat Dis. 2017;13(2):334–43.
Loh HH, Shahar MA, Loh HS, et al. Female sexual dysfunction after bariatric surgery in women with obesity: a systematic review and meta-analysis. Scand J Surg. 2022;111(1):14574969211072396.
Gokalp F, Koras O, Ugur M, et al. Bariatric surgery has positive effects on patients’ and their partners’ sexual function: a prospective study. Andrology. 2021;9(4):1119–25.
Steffen KJ, King WC, White GE, et al. Changes in sexual functioning in women and men in the 5 years after bariatric surgery. JAMA Surg. 2019;154(6):487–98.
Hsieh MF, Chen JH, Su YC, et al The increasing possibility of pregnancy postbariatric surgery: a comprehensive national cohort study in Asian population. Obes Surg. 2021;31(3):1022–9.
Musella M, Milone M, Bellini M, et al. Effect of bariatric surgery on obesity-related infertility. Surg Obes Relat Dis. 2012;8(4):445–9.
Menke MN, King WC, White GE, et al. Conception rates and contraceptive use after bariatric surgery among women with infertility: Evidence from a prospective multicenter cohort study. Surg Obes Relat Dis. 2019;15(5):777–85.
Grzegorczyk-Martin V, Freour T, De Bantel Finet A, et al. IVF outcomes in patients with a history of bariatric surgery: a multicenter retrospective cohort study. Hum Reprod. 2020;35(12):2755–62.
Nilsson-Condori E, Mattsson K, Thurin-Kjellberg A, et al. Outcomes of in-vitro fertilization after bariatric surgery: a national register-based case-control study. Hum Reprod. 2022;37(10):2474–81.
Milone M, Sosa Fernandez LM, Sosa Fernandez LV, et al. Does bariatric surgery improve assisted reproductive technology outcomes in obese infertile women? Obes Surg. 2017;27(8):2106–12.
Mechanick JI, Youdim A, Jones DB, et al. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient--2013 update: cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery. Obesity (Silver Spring). 2013;21 Suppl 1:S1–27.
Busetto L, Dicker D, Azran C, et al. Obesity management task force of the European Association for the study of obesity released “Practical Recommendations for the Post-Bariatric Surgery Medical Management.” Obes Surg. 2018;28(7):2117–21.
Chao GF, Yang J, Peahl A, Thumma JR, Dimick JB, Arterburn DE, et al. Births after bariatric surgery in the United States: incidence, obstetric outcomes, and reinterventions. Ann Surg. 2022. https://doi.org/10.1097/SLA.0000000000005438.
Chen W, Liang Y, Chen G, et al. Early pregnancy (</= 12 months) after bariatric surgery: does it really influence maternal and perinatal outcomes? Obes Surg. 2022;32(4):979–90.
Crusell M, Nilas L, Svare J, et al. A time interval of more than 18 months between a pregnancy and a Roux-en-Y gastric bypass increases the risk of iron deficiency and anaemia in pregnancy. Obes Surg. 2016;26(10):2457–62.
Stentebjerg LL, Andersen LLT, Renault K, et al. Pregnancy and perinatal outcomes according to surgery to conception interval and gestational weight gain in women with previous gastric bypass. J Matern Fetal Neonatal Med. 2017;30(10):1182–8.
Rottenstreich A, Levin G, Kleinstern G, et al. The effect of surgery-to-conception interval on pregnancy outcomes after sleeve gastrectomy. Surg Obes Relat Dis. 2018;14(12):1795–803.
Snoek KM, Steegers-Theunissen RPM, Hazebroek EJ, et al. The effects of bariatric surgery on periconception maternal health: a systematic review and meta-analysis. Hum Reprod Update. 2021;27(6):1030–55.
Shawe J, Ceulemans D, Akhter Z, et al. Pregnancy after bariatric surgery: consensus recommendations for periconception, antenatal and postnatal care. Obes Rev. 2019;20(11):1507–22.
Dineley B, Munro S, Norman WV, et al. Contraceptive counselling in 3 Canadian bariatric surgery clinics: a multicentre qualitative study of the experiences of patients and health care providers. CMAJ Open. 2022;10(1):E255–61.
Goldenshluger A, Elazary R, Ben Porat T, et al. Knowledge, attitudes, and behaviors of women during pregnancy after bariatric surgery. Surg Obes Relat Dis. 2020;16(7):925–30.
Ginstman C, Frisk J, Carlsson B, et al. Plasma concentrations of etonogestrel in women using oral desogestrel before and after Roux-en-Y gastric bypass surgery: a pharmacokinetic study. BJOG. 2019;126(4):486–92.
Moreira de Brito C, de Melo ME, Mancini MC, et al. Pharmacokinetics of oral levonorgestrel and ethinylestradiol in women after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis. 2021;17(4):673–81
Gasmi A, Bjorklund G, Mujawdiya PK, Semenova Y, Dosa A, Piscopo S, et al. Dietary supplements and bariatric surgery. Crit Rev Food Sci Nutr. 2022; 1–12. https://doi.org/10.1080/10408398.2022.2046542.
Maslin K, James A, Brown A, Bogaerts A, Shawe J. What is known about the nutritional intake of women during pregnancy following bariatric surgery? A scoping review. Nutrients. 2019;11(9):2116. https://doi.org/10.3390/nu11092116.
Rottenstreich A, Elazary R, Goldenshluger A, et al. Maternal nutritional status and related pregnancy outcomes following bariatric surgery: a systematic review. Surg Obes Relat Dis. 2019;15(2):324–32.
Araki S, Shani Levi C, Abutbul Vered S, et al. Pregnancy after bariatric surgery: effects of personalized nutrition counseling on pregnancy outcomes. Clin Nutr. 2022;41(2):288–97.
Chapmon K, Stoklossa CJ, Benson-Davies S. Integrated Health Clinical Issues Committee of the American Society for M, Bariatric S. Nutrition for pregnancy after metabolic and bariatric surgery: literature review and practical guide. Surg Obes Relat Dis. 2022;18(6):820–30.
Kwong W, Tomlinson G, Feig DS. Maternal and neonatal outcomes after bariatric surgery; a systematic review and meta-analysis: do the benefits outweigh the risks? Am J Obstet Gynecol. 2018;218(6):573–80.
Johansson K, Wikström AK, Söderling J, et al. Risk of pre-eclampsia after gastric bypass: a matched cohort study. Bjog. 2022;129(3):461–71.
Johansson K, Cnattingius S, Naslund I, et al. Outcomes of pregnancy after bariatric surgery. N Engl J Med. 2015;372(9):814–24.
Patel D, Borrelli N, Patey O, et al. Maternal cardiovascular adaptation to pregnancy in women with previous bariatric surgery. Am J Obstet Gynecol. 2022;226(3):409.e1–e16
Chevrot A, Kayem G, Coupaye M, et al. Impact of bariatric surgery on fetal growth restriction: experience of a perinatal and bariatric surgery center. Am J Obstet Gynecol. 2016;214(5):655.e1–7.
Coupaye M, Legardeur H, Sami O, et al. Impact of Roux-en-Y gastric bypass and sleeve gastrectomy on fetal growth and relationship with maternal nutritional status. Surg Obes Relat Dis. 2018;14(10):1488–94.
Yerlikaya-Schatten G, Feichtinger M, Stopp T, et al. Trajectories of fetal adipose tissue thickness in pregnancies after gastric bypass surgery. Obes Surg. 2020;30(1):96–101.
Feichtinger M, Falcone V, Schoenleitner T, et al. Intrauterine fetal growth delay during late pregnancy after maternal gastric bypass surgery. Ultraschall Med. 2020;41(1):52–9.
Stuart A, Kallen K. Risk of abdominal surgery in pregnancy among women who have undergone bariatric surgery. Obstet Gynecol. 2017;129(5):887–95.
Petrucciani N, Ciangura C, Debs T, et al. Management of surgical complications of previous bariatric surgery in pregnant women. A systematic review from the BARIA-MAT Study Group. Surg Obes Relat Dis. 2020;16(2):312–31.
Nguyen CP, Goodman LH. Fetal risk in diagnostic radiology. Semin Ultrasound CT MR. 2012;33(1):4–10.
Krishna S, McInnes MDF, Schieda N, et al. Diagnostic accuracy of MRI for diagnosis of internal hernia in pregnant women with prior Roux-en-Y gastric bypass. AJR Am J Roentgenol. 2018;211(4):755–9.
Loh HH, Francis B, Lim LL, et al. Improvement in mood symptoms after post-bariatric surgery among people with obesity: a systematic review and meta-analysis. Diabetes Metab Res Rev. 2021;37(8):e3458.
Muller A, Hase C, Pommnitz M, et al. Depression and suicide after bariatric surgery. Curr Psychiatry Rep. 2019;21(9):84.
Kauppila JH, Santoni G, Tao W, et al. Risk factors for suicide after bariatric surgery in a population-based nationwide study in five Nordic countries. Ann Surg. 2022;275(2):e410–4.
Kim J, Kelley J, Davidson L, et al. Depression and anxiety incidence during pregnancy between bariatric surgery patients and matched control subjects. Obes Surg. 2022;32(6):1962–8.
Kim J, Davidson L, Hunt S, et al. Association of prenatal substance use disorders with pregnancy and birth outcomes following bariatric surgery. Int J Obes (Lond). 2022;46(1):107–12.
Adam S, Ammori B, Soran H, et al. Pregnancy after bariatric surgery: screening for gestational diabetes. BMJ. 2017;356:j533.
Freitas C, Araujo C, Caldas R, et al. Effect of new criteria on the diagnosis of gestational diabetes in women submitted to gastric bypass. Surg Obes Relat Dis. 2014;10(6):1041–6.
Rottenstreich A, Elazary R, Ezra Y, et al. Hypoglycemia during oral glucose tolerance test among post-bariatric surgery pregnant patients: incidence and perinatal significance. Surg Obes Relat Dis. 2018;14(3):347–53.
Benhalima K, Minschart C, Ceulemans D, Bogaerts A, Van Der Schueren B, Mathieu C, Devlieger R. Screening and management of gestational diabetes mellitus after bariatric surgery. Nutrients. 2018;10(10):1479. https://doi.org/10.3390/nu10101479.
Brix JM, Kopp HP, Hollerl F, et al. Frequency of hypoglycaemia after different bariatric surgical procedures. Obes Facts. 2019;12(4):397–406.
Stentebjerg LL, Madsen LR, Stoving RK, et al. Hypoglycemia in pregnancies following gastric bypass-a systematic review and meta-analysis. Obes Surg. 2022;32(6):2047–55.
Lupoli R, Lembo E, Rainone C, et al. Rate of post-bariatric hypoglycemia using continuous glucose monitoring: a meta-analysis of literature studies. Nutr Metab Cardiovasc Dis. 2022;32(1):32–9.
Maric T, Kanu C, Muller DC, et al. Fetal growth and fetoplacental circulation in pregnancies following bariatric surgery: a prospective study. BJOG. 2020;127(7):839–46.
Ciangura C, Coupaye M, Deruelle P, et al. Clinical practice guidelines for childbearing female candidates for bariatric surgery, pregnancy, and post-partum management after bariatric surgery. Obes Surg. 2019;29(11):3722–34.
Christopher KM, Abdelsalam A, Flick L, et al. Pregnancy complications in women with weight loss surgery compared to a non-surgical population of women with obesity. Obes Surg. 2022;32(4):991–7.
Getahun D, Fassett MJ, Jacobsen SJ, et al. Perinatal outcomes after bariatric surgery. Am J Obstet Gynecol. 2022;226(1):121.e1–e16
Auger N, Ukah UV, Monnier M, et al. Risk of severe maternal morbidity after bariatric surgery: retrospective cohort study. Ann Surg. 2021;274(3):e230–5.
Stephansson O, Johansson K, Soderling J, et al. Delivery outcomes in term births after bariatric surgery: population-based matched cohort study. PLoS Med. 2018;15(9):e1002656.
Neovius M, Pasternak B, Naslund I, et al. Association of maternal gastric bypass surgery with offspring birth defects. JAMA. 2019;322(15):1515–7.
Josefsson A, Bladh M, Wirehn AB, et al. Risk for congenital malformations in offspring of women who have undergone bariatric surgery. A national cohort. BJOG. 2013;120(12):1477–82.
Pelizzo G, Calcaterra V, Fusillo M, et al. Malnutrition in pregnancy following bariatric surgery: three clinical cases of fetal neural defects. Nutr J. 2014;13:59.
Kang L, Marty D, Pauli RM, et al. Chondrodysplasia punctata associated with malabsorption from bariatric procedures. Surg Obes Relat Dis. 2010;6(1):99–101.
Auger N, Bilodeau-Bertrand M, Tith RM, et al. Bariatric surgery and the risk of congenital anomalies in subsequent pregnancies. Am J Clin Nutr. 2019;110(5):1168–74.
Persson M, Cnattingius S, Villamor E, et al. Risk of major congenital malformations in relation to maternal overweight and obesity severity: cohort study of 1.2 million singletons. BMJ. 2017;357:j2563.
Benjamin RH, Littlejohn S, Mitchell LE. Bariatric surgery and birth defects: a systematic literature review. Paediatr Perinat Epidemiol. 2018;32(6):533–44.
Parent B, Martopullo I, Weiss NS, et al. Bariatric surgery in women of childbearing age, timing between an operation and birth, and associated perinatal complications. JAMA Surg. 2017;152(2):128–35.
Akhter Z, Rankin J, Ceulemans D, et al. Pregnancy after bariatric surgery and adverse perinatal outcomes: a systematic review and meta-analysis. PLoS Med. 2019;16(8):e1002866.
Celiker MY, Chawla A. Congenital B12 deficiency following maternal gastric bypass. J Perinatol. 2009;29(9):640–2.
Martens WS 2nd, Martin LF, Berlin CM Jr. Failure of a nursing infant to thrive after the mother’s gastric bypass for morbid obesity. Pediatrics. 1990;86(5):777–8.
Jans G, Devlieger R, De Preter V, et al. Bariatric surgery does not appear to affect women’s breast-milk composition. J Nutr. 2018;148(7):1096–102.
Garretto D, Kim YK, Quadro L, et al. Vitamin A and beta-carotene in pregnant and breastfeeding post-bariatric women in an urban population. J Perinat Med. 2019;47(2):183–9.
Gimenes JC, Nicoletti CF, de Souza Pinhel MA, et al. Nutritional status of children from women with previously bariatric surgery. Obes Surg. 2018;28(4):990–5.
Dickens CE, Safer DL, Runfola CD, et al. The offspring of parents undergoing a weight loss surgery: a systematic review. Surg Obes Relat Dis. 2020;16(6):806–15.
Smith J, Cianflone K, Biron S, et al. Effects of maternal surgical weight loss in mothers on intergenerational transmission of obesity. J Clin Endocrinol Metab. 2009;94(11):4275–83.
Rex SM, Russel K, Reiter-Purtill J, et al. A cross-sectional examination of the home food environments of mothers who have undergone metabolic and bariatric surgery: a pilot study. Surg Obes Relat Dis. 2020;16(12):2016–21.
Zeller MH, Robson SM, Reiter-Purtill J, et al. Halo or horn? A qualitative study of mothers’ experiences with feeding children during the first year following bariatric surgery. Appetite. 2019;142:104366.
Van De Maele K, De Geyter C, Vandenplas Y, Gies I, Devlieger R. Eating habits of children born after maternal bariatric surgery. Nutrients. 2020;12(9):2577. https://doi.org/10.3390/nu12092577.
Van De Maele K, Bogaerts A, De Schepper J, et al. Adiposity, psychomotor and behaviour outcomes of children born after maternal bariatric surgery. Pediatr Obes. 2021;16(5):e12749.
Damti P, Friger M, Landau D, et al. Offspring of women following bariatric surgery and those of patients with obesity are at an increased risk for long-term pediatric endocrine morbidity. Arch Gynecol Obstet. 2019;300(5):1253–9.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Ethical Approval
For this type of study formal consent is not required.
Informed Consent
Informed consent does not apply in this study.
Conflict of Interest
The authors declare no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Key points
Insufficient attention is paid to bariatric surgery and reproductive health; Mixed influence of the bariatric surgery on reproductive health; Conversations should be made about reproductive health before bariatric surgery.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Yang, JC., Chen, G. & Du, X. Benefits and Risks of Bariatric Surgery on Women’s Reproductive Health: a Narrative Review. OBES SURG 33, 1587–1595 (2023). https://doi.org/10.1007/s11695-023-06513-6
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11695-023-06513-6