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What Are the Micronutrient Deficiencies Responsible for the Most Common Nutritional Symptoms After Bariatric Surgery?

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Abstract

Background

Many patients complain of nutritional symptoms after bariatric surgery (BS), including hair loss, cramps, and paresthesia, but their link with biological alterations has been poorly studied.

Objectives

To assess in a large cohort of subjects the relationship between nutritional symptoms and biological deficits both in the short term (ST ≤ 1 year) and long term (LT ≥ 3 years) after the 2 most common procedures, Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG).

Methods

Nutritional symptoms and biological parameters (including vitamins, minerals, and protein parameters) were prospectively recorded. All subjects with complete clinical and biological assessments from 2011 to 2018 were included.

Results

After BS, 555 subjects were studied in the ST (50% RYGB) and 494 in the LT (79% RYGB); multivitamin intake was 97% and 78%, respectively. The proportion of patients with hair loss decreased from 65 (ST) to 35% (LT) (p < 0.001). In contrast, cramps increase from 7 to 32% and paresthesia from 11 to 18% (p < 0.001). No significant difference was found between SG and RYGB. In subjects with hair loss, blood parameters of protein and iron metabolism were significantly lower than in subjects without hair loss, both in the ST and LT. In contrast, neither zinc nor group B vitamin levels were significantly different. None of the nutritional parameters tested was clearly associated with cramps and paresthesia.

Conclusion

After BS, the most frequent nutritional symptom is hair loss, essentially linked to iron and protein deficiencies. The causes of other nutritional symptoms are less clear and probably more heterogeneous.

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Authors and Affiliations

  1. Service des Explorations Fonctionnelles, Centre intégré de prise en charge de l’obésité (CINFO), Hôpital Louis Mourier APHP.Nord, Colombes and Université de Paris, 92700, Colombes, France

    Séverine Ledoux, Ouidad Sami & Muriel Coupaye

  2. Service des Explorations Fonctionnelles, Hôpital Bichat APHP.Nord, Université de Paris, 75018, Paris, France

    Martin Flamant

  3. Service de Chirurgie, Centre intégré de prise en charge de l’obésité (CINFO), Hôpital Louis Mourier APHP.Nord, 92700, Colombes, France

    Daniela Calabrese

  4. Service de Biochimie, Hôpital Louis Mourier APHP.Nord, 92700, Colombes, France

    Catherine Bogard

Authors
  1. Séverine Ledoux
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  2. Martin Flamant
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  3. Daniela Calabrese
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  4. Catherine Bogard
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  5. Ouidad Sami
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  6. Muriel Coupaye
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Corresponding author

Correspondence to Séverine Ledoux.

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The authors declare that they have no conflict of interest.

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Informed consent was obtained from all individual participants included in the study.

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Ledoux, S., Flamant, M., Calabrese, D. et al. What Are the Micronutrient Deficiencies Responsible for the Most Common Nutritional Symptoms After Bariatric Surgery?. OBES SURG 30, 1891–1897 (2020). https://doi.org/10.1007/s11695-020-04412-8

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  • DOI: https://doi.org/10.1007/s11695-020-04412-8

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