Abstract
Background
Serum 25-hydroxyvitamin D [25(OH)D] and parathormone (PTH) have an inverse relation. The 25(OH)D threshold required to maximally suppress PTH has been used as a marker of optimal vitamin D status. Obesity is associated with lower serum levels of 25(OH)D and higher levels of PTH; however, the relation between these hormones in this setting is not well established. We aimed to assess the influence of excessive weight and weight loss after bariatric surgery on the relation between serum 25(OH)D and PTH.
Methods
Anthropometric and analytical parameters of phospho-calcium metabolism from 290 patients undergoing bariatric surgery were analyzed. The association between 25(OH)D and PTH before and 1 year after surgery was evaluated through Student’s t test and simple and multivariable linear regression.
Results
At baseline, there was an inverse association between 25(OH)D and PTH plasma levels (β = − 0.571; p = 0.001). The threshold for a significant increase of PTH at baseline was a 25(OH)D level of < 10 ng/mL (p < 0.001). At 1 year after surgery (n = 194), the association between the two variables was weaker (β = − 0.291; p = 0.014). The 25(OH)D threshold for a significant increase in serum PTH levels was lower in patients who maintained obesity (n = 77) [25(OH)D 5 vs 10 ng/mL].
Conclusions
PTH suppression threshold observed in patients with morbid obesity before and after bariatric surgery is lower than that described for the general population, suggesting that the 25(OH)D plasma levels may not be representative of the body’s vitamin D reserves. Other studies are required to demonstrate which optimal vitamin D levels need to be aimed for in obesity, in order to improve obese patients’ bone health.
Similar content being viewed by others
References
Ferrari D, Lombardi G, Banfi G. Concerning the vitamin D reference range: pre-analytical and analytical variability of vitamin D measurement. Biochem Med (Zagreb). 2017;27(3):030501.
Sai AJ, Walters RW, Fang X, et al. Relationship between vitamin D, parathyroid hormone, and bone health. J Clin Endocrinol Metab. 2011;96(3):E436–46.
Khazai N, Judd SE, Tangpricha V, et al. Calcium and vitamin D: skeletal and Extraskeletal health. Curr Rheumatol Rep. 1998;10(2):110–7.
Mehmood ZH, Papandreou D. An updated mini review of vitamin D and obesity: adipogenesis and inflammation state. Open Access Maced J Med Sci. 2016;4(3):526–32.
Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96:53–8.
Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–30.
Vuistiner P, Rousson V, Henry H, et al. A population-based model to consider the effect of seasonal variation on serum 25(OH)D and vitamin D status. Biomed Res Int. 2015;2015:168189.
Sempos CT, Heijboer AC, Bikle DD, et al. Vitamin D assays and the definition of hypovitaminosis D: results from the first international conference on controversies in vitamin D. Br J Clin Pharmacol. 2018;84(10):2194–207.
Binkley N, Dawson-Hughes B, Durazo-Arvizu R, et al. Vitamin D measurement standardization: the way out of the chaos. J Steroid Biochem Mol Biol. 2017;173:117–21.
Krall EA, Sahyoun N, Tannenbaum S, et al. Effect of vitamin D intake on seasonal variations in parathyroid hormone secretion in postmenopausal women. N Engl J Med. 1989;321(26):1777–83.
Lotito A, Teramoto M, Cheung M, et al. Serum parathyroid hormone responses to vitamin D supplementation in overweight/obese adults: a systematic review and meta-analysis of randomized clinical trials. Nutrients. 2016;9(3)
Arterburn DE, Courcoulas AP. Bariatric surgery for obesity and metabolic conditions in adults. BMJ. 2014;349:g3961.
Angrisani L, Santonicola A, Iovino P, et al. Bariatric surgery worldwide 2013. Obes Surg. 2015;25:1822–32.
Grethen E, McClintock R, Gupta CE, et al. Vitamin D and hyperparathyroidism in obesity. J Clin Endocrinol Metab. 2011;96(5):1320–6.
Pereira-Santos M, Costa P, Assis A, et al. Obesity and vitamin D deficiency: a systematic review and meta-analysis. Obes Rev. 2015;16(4):341–9.
Vimaleswaran KS, Berry DJ, Lu C, et al. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med. 2013;10(2):e1001383.
Lespessailles E, Paccou J, Javier RM, et al. GRIO Scientific Committee. Obesity, bariatric surgery and fractures. J Clin Endocrinol Metab. 2019;
Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604–12.
Tian Z, Fan XT, Li SZ, et al. Changes in bone metabolism after sleeve gastrectomy versus gastric bypass: a meta-analysis. Obes Surg. 2019:1–10.
Corbeels K, Verlinden L, Lannoo M, et al. Thin bones: vitamin D and calcium handling after bariatric surgery. Bone Rep. 2018 Jun;8:57–63.
Hill KM, McCabe GP, McCabe LD, et al. An inflection point of serum 25-hydroxyvitamin D for maximal suppression of parathyroid hormone is not evident from multi-site pooled data in children and adolescents. J Nutr. 2010;140(11):1983–8.
Malabanan A, Veronikis IE, Holick MF. Redifining vitamin D insufficiency. Lancet. 1998;351(9105):805–6.
Dawson-Hughes B, Harris SS, Dallal GE. Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women. Am J Clin Nutr. 1997;65(1):67–71.
Valcour A, Blocki F, Hawkins DM, et al. Effects of age and serum 25-OH-vitamin D on serum parathyroid hormone levels. J Clin Endocrinol Metab. 2012;97:3898–995.
Shapses SA, Lee EJ, Sukumar D, et al. The effect of obesity on the relationship between serum parathyroid hormone and 25-hydroxivitamin D in women. J Clin Endocrinol Metab. 2013;98(5):E886–90.
Amini Z, Bryant S, Smith C, et al. Is the serum vitamin D-parathyroid hormone relationship influenced by obesity in children? Horm Res Paediatr. 2013;80(4):252–6.
Beckman LM, Earthman CP, Thomas W, et al. Serum 25(OH) vitamin D concentration changes after Roux-en-Y gastric bypass surgery. Besity. 2013;21(12):E599–606.
Bell NH, Epstein S, Greene A, et al. Evidence for alteration of the vitamin-D endocrine system in obese subjects. J Clin Invest. 1985;76(1):370–3.
Parikh SJ, Edelman M, Uwaifo GI, et al. The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab. 2004;89(3):1196–9.
Jones G. Interpreting vitamin D assay results: proceed with caution. Clin J Am Soc Nephrol. 2015;10:331–4.
Snellman G, Melhus H, Gedeborg R, et al. Determining vitamin D status: a comparison between commercially available assays. PLoS One. 2010;5(7):e11555.
Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol. 2009;19(2):73–8.
Holick MF. The D-batable parathyroid hormone plateau. Am J Med. 2011;124(12):1095–6.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
The authors declare that they have no conflict of interest.
Ethical Approval
All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments, or comparable ethical standards.
Informed Consent
For this type of study formal consent is not required.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Electronic supplementary material
ESM 1
(DOCX 18 kb)
Rights and permissions
About this article
Cite this article
Salazar, D.A., Ferreira, M.J.S., Neves, J.S. et al. Variable Thresholds of Vitamin D Plasma Levels to Suppress PTH: the Effect of Weight and Bariatric Surgery. OBES SURG 30, 1551–1559 (2020). https://doi.org/10.1007/s11695-019-04351-z
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11695-019-04351-z