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Updates on Monogenic Obesity in a Multifactorial Disease

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Abstract

Obesity is a worldwide epidemic with rates nearly doubling over the last 30 years. Despite increasing prevalence, the multifactorial pathogenesis of obesity continues to be widely misunderstood. Investigating genetic drivers in the development of obesity is an important area of focus, as genetics move to the forefront of medicine and personalized treatment evolves. Thus, this narrative review focused on four genes which have genome-wide association study–documented links to obesity and obesity syndromes. We explored their involvement in the predisposition, progression, and prognosis of obesity. Leptin, leptin receptor, pro-opiomelanocortin, and melanocortin 4 receptor are our four genes of interest, and herein we elaborated on the current literature, pathogenesis, and available treatments for patients with these specific genetic mutations.

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Funding

Funding for this study was provided by the Center for Advanced Surgical Technology at the University of Nebraska Medical Center

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Authors and Affiliations

  1. College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA

    Jared Baxter & Laura Flores

  2. Center for Advanced Surgical Technology, University of Nebraska Medical Center, Omaha, NE, USA

    Priscila Rodrigues Armijo, Crystal Krause, Sarah Samreen & Tiffany Tanner

  3. General Surgery, Department of Surgery, University of Nebraska Medical Center, 986245 Nebraska Medical Center, Omaha, NE, 68198-6245, USA

    Sarah Samreen & Tiffany Tanner

Authors
  1. Jared Baxter
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  2. Priscila Rodrigues Armijo
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  3. Laura Flores
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  4. Crystal Krause
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  5. Sarah Samreen
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  6. Tiffany Tanner
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Corresponding author

Correspondence to Tiffany Tanner.

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The authors declare that they have no conflict of interest.

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This study does not involve human or animal subjects.

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Baxter, J., Armijo, P.R., Flores, L. et al. Updates on Monogenic Obesity in a Multifactorial Disease. OBES SURG 29, 4077–4083 (2019). https://doi.org/10.1007/s11695-019-04200-z

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