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The Impact of Age on the Prevalence of Sarcopenic Obesity in Bariatric Surgery Candidates

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Abstract

Background

Sarcopenia pre-dating bariatric surgery (BS) has been suggested as concern for the use of BS in older-adults with morbid obesity.

Objective

To evaluate the impact of age on the prevalence of sarcopenic obesity (SO) in BS-candidates.

Methods

Cross-sectional study including 1370 consecutive BS-candidates aged ≥18, and grouped according to age: 18–39 (reference group), 40–49, 50–59 and ≥ 60 years. From body composition analysis data obtained using bioelectrical impedance, skeletal muscle mass (SMM), SMM index (SMMI=SMM/height2), and percentage of SMM (%SMM = SMM/BW*100) were calculated. Class I or class II SO was adjudicated, respectively, when a value between > − 1 and − 2, or > −2 standard deviations from the regression line from the gender-specific distribution of the relationship between BMI and SMMI or the %SMM in the reference group was encountered.

Results

According to the SMMI distribution, prevalence of class I and class II SO in the whole cohort was respectively 16.4% and 4.6%. SO was more prevalent in females (p < 0.005). Proportion of subjects with SO positively correlated with older age category in females (Tau-c = 0.149, p < 0.001) but not in males. In females aged ≥60, class I SO was present in 29.1%, and class II in 12.8%. Similar results were obtained when %SMM was used (Cohen’s k-coefficient = 0.886, p < 0.001). Age and female gender were identified as independent preditors of SO, whereas CRP or the presence of obesity-associated comorbidities were not.

Conclusion

Age is a risk factor for SO in BS-candidates. SO is fairly common in female subjects aged >60 years that are candidates to BS.

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Acknowledgments

This work was supported by a grant from the Fondo de Investigaciones Sanitarias (PI17/00215), Instituto de Salud Carlos III (Madrid, Spain), and European Funds for Regional Development (FEDER) from the European Union.

Funding

This work was supported by a grant from the Fondo de Investigaciones Sanitarias (PI17/00215), Instituto de Salud Carlos III (Madrid, Spain), and European Funds for Regional Development (FEDER) from the European Union.

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Authors and Affiliations

  1. Obesity Unit, Endocrinology Department, Hospital Clinic Barcelona Universitar, Villarroel 170, 08036, Barcelona, Spain

    Judit Molero, Violeta Moizé, Lilliam Flores, Ana De Hollanda, Amanda Jiménez & Josep Vidal

  2. Institut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain

    Lilliam Flores, Ana De Hollanda, Amanda Jiménez & Josep Vidal

  3. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

    Lilliam Flores & Josep Vidal

  4. Centro de Investigación Biomédica en Obesidad y Nutrición (CIBEROBN), Barcelona, Spain

    Amanda Jiménez

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  1. Judit Molero
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  2. Violeta Moizé
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Correspondence to Josep Vidal.

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The authors of this manuscript have no personal or financial conflicts of interest to declare.

Statement of Authorship and Ethics

The individual contribution of the authors to this manuscript was as follows: (1) the conception and design of the study, or acquisition of data, or analysis and interpretation of data: JM, LF, JV; (2) drafting the article or revising it critically for important intellectual content: JM, LF, VM, AA, AdH, AJ, JV; (3) final approval of the version to be submitted: JM, LF, VM, AA, AdH, AJ, JV. We alse declare the present work complies with all requirements from the Committee on Publication Ethics.

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ESM 1

Distribution of relationship between SMMI and BMI [panels A (males) and B (females)] and SMM% and BMI [panels C (males) and D (females)] in the study cohort. The regression line and the lines corresponding to + or -1 or + or – 2 standard deviations from the regression line in the reference group (age 18-39 y) are shown. SMMI: skeletal muscle mass index, %SMM: percent skeletal muscle mass, BMI: body mass index. (PPTX 204 kb)

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Molero, J., Moizé, V., Flores, L. et al. The Impact of Age on the Prevalence of Sarcopenic Obesity in Bariatric Surgery Candidates. OBES SURG 30, 2158–2164 (2020). https://doi.org/10.1007/s11695-019-04198-4

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  • DOI: https://doi.org/10.1007/s11695-019-04198-4

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