Skip to main content
SpringerLink
Log in

Recovery of Pistacia lentiscus edible oil by using 2-methyloxolane as an eco-friendly and sustainable solvent

  • Original Paper
  • Published:
Journal of Food Measurement and Characterization Aims and scope Submit manuscript

Abstract

The extraction of oil from oilseeds is conventionnaly performed using n-hexane. However, due to its toxicity and drawbacks, there is a growing need to explore greener solvents. In this study, 2-methyloxolane (2-MeOx) was selected to evaluate its potential as a replacement for n-hexane in extracting lipophilic compounds from Pistacia lentiscus seeds. Hansen solubility parameters were used to predict the solubility of target compounds in the selected solvents. Experimental analyses were focused on the extraction yield, fatty acid composition, sterol and tocopherol contents. As n-hexane, ours results indicated that 2-MeOx yielded similar performance in terms of extraction yield, fatty acid composition, sterol and tocopherol contents. Additionally, 2-MeOx extract demonstrated a high polyphenol content and exhibited strong antioxidant potential. Furthermore, it was shown that green extracted oil at low concentration had no cytotoxicity against macrophages. Moreover, the oil exhibited anti-inflammatory activity and suppressed nitric oxide (NO) secretion considerably on LPS-stimulated macrophages with IC50 value of 33.04 µg/mL.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. D.R. Joshi, N. Adhikari, An overview on common organic solvents and their toxicity. J. Pharm. Res. Int. 28, 1–18 (2019). https://doi.org/10.9734/JPRI/2019/v28i330203

    Article  Google Scholar 

  2. V. Rapinel, O. Claux, M. Abert-Vian, C. McAlinden, M. Bartier, N. Patouillard, L. Jacques, F. Chemat, Molecules 25, 3417 (2020). https://doi.org/10.3390/molecules25153417

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. S. Gharby, H.K. Ravi, D. Guillaume, M.A. Vian, F. Chemat, Z. Charrouf, OCL 27, 27 (2020)

    Article  CAS  Google Scholar 

  4. A. Chemat, H.K. Ravi, A.C. Hostequin, H. Burney, V. Tomao, A.S. Fabiano-Tixier, OCL 29, 7 (2022)

    Article  CAS  Google Scholar 

  5. E. Chaabani, M. Vian, S. Dakhlaoui, S. Bourgou, F. Chemat, R. Ksouri, OCL 26, 25 (2019)

    Article  Google Scholar 

  6. Y.L. Kua, S. Gan, A. Morris, H.K. Ng, Sustain. Chem. Pharm. 4, 21–31 (2016)

    Article  CAS  Google Scholar 

  7. A.G. Sicaire, M.A. Vian, F. Fine, P. Carré, S. Tostain, F. Chemat, Ultrason. Sonochem. 31, 319–329 (2016)

    Article  CAS  PubMed  Google Scholar 

  8. S. Trad, E. Chaabani, W. Aidi Wannes, S. Dakhlaoui, S. Nait Mohamed, S. Khammessi, M. Hammami, S. Bourgou, M. Saidani Tounsi, A.S. Fabiano-Tixier, I. Bettaieb Rebey, Foods 12, 3263 (2023). https://doi.org/10.3390/foods12173263

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. O. Claux, V. Rapinel, P. Goupy, N. Patouillard, M. Abert Vian, L. Jacques, F. Chemat, ACS Sustain. Chem. Eng. 9, 7211–7223 (2021)

    Article  CAS  Google Scholar 

  10. EFSA CEP Panel (EFSA Panel on Food Contact Materials, Enzymes and Processing Aids), C. Lambre, J.M.B. Baviera, C. Bolognesi, A. Chesson, P.S. Cocconcelli, R. Crebelli, D.M. Gott, K. Grob, E. Lampi, M. Mengelers, A. Mortensen, G. Riviere, I.L. Steffensen Tlustos, C. Van, H. Loveren, L. Vernis, H. Zorn, M. Bignami, P. Furst, A. Tard, E. Van Haver, EFSA. J. 20, 7138, 23 (2022). https://doi.org/10.2903/j.efsa.2022.7138

  11. H. Trabelsi, O.A. Cherif, F. Sakouhi, P. Villeneuve, J. Renaud, B. Nathalie, S. Boukhchina, P. Mayer, Food Chem. 131, 434–440 (2012)

    Article  CAS  Google Scholar 

  12. S. Ben Khedir, D. Moalla, N. Jardak, M. Mzid, Z. Sahnoun, T. Rebai, Biotech. Histochem. 91, 480–491 (2016)

    Article  CAS  PubMed  Google Scholar 

  13. C. Dhieb, H. Trabelsi, S. Boukhchina, N. Sadfi-Zouaoui, J. Food Nutr. Res. 9, 177–181 (2021). https://doi.org/10.12691/jfnr-9-4-1

    Article  CAS  Google Scholar 

  14. K. Hamdi, N.B. Amoura, A. Noui, F. Dalia, M. Siline, A. Belkhiri, J. Pharm. Res. Int. 35, 11–23 (2023). https://doi.org/10.9734/jpri/2023/v35i157376

    Article  CAS  Google Scholar 

  15. N. Belyagoubi-Benhammou, L. Belyagoubi, A. El Zerey-Belaskri, A. Zitouni, N. Ghembaza, H. Benhassaini, F. Atik-Bekkara, A. Piras, D. Falconieri, A. Rosa, J. Food Meas. Charact. 12, 1408–1412 (2018). https://doi.org/10.1007/s11694-018-9755-y

    Article  Google Scholar 

  16. C. Hansen, J. Paint Technol. 39, 104–117 (1967)

    CAS  Google Scholar 

  17. E. Angles, P. Jaouen, J. Pruvost, L. Marchal, Algal Res. 21, 27–34 (2017)

    Article  Google Scholar 

  18. K. Bundeesomchok, A. Filly, N. Rakotomanomana, P. Panichayupakaranant, F. Chemat, LWT 65, 297–303 (2016)

    Article  CAS  Google Scholar 

  19. C. Breil, A. Meullemiestre, M. Vian, F. Chemat, Molecules 21, 196 (2016). https://doi.org/10.3390/molecules21020196

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. S. Ben-Youssef, J. Fakhfakh, C. Breil, M. Abert-Vian, F. Chemat, N. Allouche, Ind. Crops Prod. 108, 520–525 (2017)

    Article  CAS  Google Scholar 

  21. C. Hansen, Hansen Solubility Parameters: A User’s Handbook, 2nd edn. (CRC Press, Boca Raton, 2007)

    Book  Google Scholar 

  22. A.G. Sicaire, M. Vian, F. Fine, F. Joffre, P. Carré, S. Tostain, F. Chemat, Int. J. Mol. Sci. 16, 8430–8453 (2015)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. ISO 9936:2016, Animal and vegetable fats and oils: Determination of tocopherol and tocotrienol contents by high-performance liquid chromatography

  24. ISO 12228–1: 2014, Determination of individual and total sterols contents - Gas chromatographic method-Part 1: Animal and vegetable fats and oils

  25. E. Chaabani, M. Abert Vian, I. Bettaieb Rebey, S. Bourgou, F. Zar Kalai, F. Chemat, R. Ksouri, J. Food Meas. Charact. 17, 4705–4714 (2023). https://doi.org/10.1007/s11694-023-01983-9

    Article  Google Scholar 

  26. H. Hanato, T. Kagawa, J. Yasuhara, T. Okuda, Chem. Pharm. Bull. 36, 1090–1097 (1988)

    Google Scholar 

  27. J. O’Brien, I. Wilson, T. Orton, F. Pognan, Eur. J. Biochem. 267, 5421–5426 (2000). https://doi.org/10.1046/j.1432-1327.2000.01606.x

    Article  PubMed  Google Scholar 

  28. I. Aboura, N. Abdelhafid, M. Belarbi, B. Murtaza, A. Fluckiger, A. Dumont, C. Benammar, M. Saidani Tounsi, F. Ghiringhelli, M. Rialland, N. Akhtar Khan, A. Hichami, Biomed. Pharmacother. 96, 1022–1035 (2017). https://doi.org/10.1016/j.biopha.2017.11.125

    Article  CAS  PubMed  Google Scholar 

  29. W. Dhifi, N. Jelali, E. Chaabani, M. Béji, S. Fatnassi, S. Omri, W. Mnif, Afr. J. Agric. Res. 8, 16 (2013)

    Google Scholar 

  30. H. Dakiche, M. Khali, H. Boutoumi, Rec. Nat. Prod. 11, 171–184 (2017)

    CAS  Google Scholar 

  31. S.M. De Morais, J.E. Teles do Nascimento, A.A. de Sousa Silva, J.E. Ribeiro Honório Junior, D.C.S. Nunes Pinheiro, R. Vasconcelos de Oliveira, Acta Sci. Vet. 45, 1437 (2017)

    Google Scholar 

  32. F. Mezni, S. Shili, N. Ben Ali, M. Larbi Khouja, A. Khaldi, A. Maaroufi, Pharm. Biol. 54, 747–751 (2016)

    Article  CAS  PubMed  Google Scholar 

  33. F. Mezni, A. Labidi, M. Msallem, M. Boussaid, M.L. Khouja, A. Khaldi, J. Mater. Environ. Sci. 5, 1703–1708 (2014)

    Google Scholar 

  34. M. Tej Yaakoubi, S. Dhaou, Revue. R. A. 1, 30–39 (2007)

    Google Scholar 

  35. T.H. Borges, J.A. Pereira, C. Cabrera-Vique, I. Seiquer, J. Funct. Foods 37, 209–218 (2017)

    Article  CAS  Google Scholar 

  36. M. Hijab, J. Saleem, P. Parthasarathy, H.R. Mackey, G. McKay, Biomass Convers. Biorefinery 11, 727–740 (2021)

    Article  CAS  Google Scholar 

  37. M. Servili, G.F. Montedoro, Eur. J. Lipid Sci. Technol. 104, 602–613 (2002)

    Article  CAS  Google Scholar 

  38. R. Marfil, R. Giménez, O. Martínez, P.R. Bouzas, J.A. Rufián-Henares, M. Mesías, C. Cabrera-Vique, Eur. J. Lipid Sci. Technol. 11, 886–893 (2011)

    Article  Google Scholar 

  39. A. Valavanidis, C. Nisiotou, Y. Papageorgiou, I. Kremli, N. Satravelas, N. Zinieris, H. Zygalaki, J. Agric. Food Chem. 52, 2358–2365 (2004)

    Article  CAS  PubMed  Google Scholar 

  40. I. Soufli, R. Toumi, H. Rafa, C. Touil-Boukoffa, World. J. Gastrointest. Pharmacol. Ther. 7, 353–360 (2016)

    Article  PubMed  PubMed Central  Google Scholar 

  41. S.B. Abramson, A.R. Amin, R.M. Clancy, M. Attur, Best Pract. Res. Clin. Rheumatol. 15, 831–845 (2001)

    Article  CAS  PubMed  Google Scholar 

  42. S. Bourgou, I. Bettaieb Rebey, S. Dakhlaoui, K. Msaada, M. Saidani Tounsi, R. Ksouri, M.L. Fauconnier, I. Hamrouni-Sellami, Phytochem. Anal. 31, 37–45 (2020). https://doi.org/10.1002/pca.2864

    Article  CAS  PubMed  Google Scholar 

  43. S. Devaraj, S. Leonard, M.G. Traber, I. Jialal, Free Radic. Biol. Med. 44, 1203–1208 (2008). https://doi.org/10.1016/j.freeradbiomed.2007.12.018

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Avignon University, INRAE, UMR 408, GREEN Extraction Team, Avignon, France

    Emna Chaabani & Maryline Abert Vian

  2. Laboratory of Aromatic and Medicinal Plants (LPAM), Biotechnology Center of Borj-Cedria, BP 901, 2050, Hammam-Lif, Tunisia

    Emna Chaabani, Iness Bettaieb Rebey, Soumaya Bourgou, Majdi Hammami & Riadh Ksouri

Authors
  1. Emna Chaabani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Iness Bettaieb Rebey
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Soumaya Bourgou
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Majdi Hammami
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Riadh Ksouri
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Maryline Abert Vian
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Iness Bettaieb Rebey or Riadh Ksouri.

Ethics declarations

Conflict of interest

No potential conflict of interest was reported by the authors.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chaabani, E., Bettaieb Rebey, I., Bourgou, S. et al. Recovery of Pistacia lentiscus edible oil by using 2-methyloxolane as an eco-friendly and sustainable solvent. Food Measure 18, 2526–2534 (2024). https://doi.org/10.1007/s11694-023-02327-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11694-023-02327-3

Keywords

Search

Navigation