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Voltammetric determination of 5-nitroimidazole derivatives in honey and HPLC-MS/MS confirmation

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Abstract

The method of voltammetric determination of nitroimidazoles in honey is developed. This method is based on the reduction of nitroimidazoles nitro group on the mercury drop indicator electrode. The obtained values of LODs for nitroimidazoles are as follows: 1.5 × 10−7 M, 8.6 × 10−8 M and 2.0 × 10−7 M for metronidazole, dimetridazole, and ipronidazole, and the linear correlation coefficients are 0.99974, 0.99987 and 0.99849, respectively, which tend towards to 1. The minimum amount of metronidazole that can be detected by means of our method, using simple dissolving of honey sample in water is 300 µg of metronidazole per 1 kg of honey. The developed voltammetric technique’s accuracy was confirmed by the “added-found” method and by HPLC-MS/MS analysis. The calculated amount of metronidazole in the tested model solution is in good agreement with the amount, introduced into honey. The calculated values of texp are 0.52, 0.48 and 0.43 for three different concentrations. Significant advantages of the method are effortless sample preparation, fast procedure of analysis, the possibility of miniaturization, low cost, not necessary use of organic solvents.

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Data availability

Data is available on request from the authors. The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Funding

The study was funded by the Ministry of Education and Science of Ukraine.

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Authors and Affiliations

  1. Analytical Chemistry Department, Chemistry Faculty, Ivan Franko National University of Lviv, Kyryla i Mefodia Str. 6, Lviv, 79005, Ukraine

    Kateryna Plotnikova, Liliya Dubenska, Petro Rydchuk & Sophia Ivakh

  2. Department of Life Safety, Ivan Franko National University of Lviv, Doroshenka Str. 41, Lviv, 79000, Ukraine

    Solomiya Pysarevska

  3. National Reference Laboratory of Veterinary Drug Residues Control, State Scientific Research Control Institute of Veterinary Medicinal Products and Feed Additives, Donetska Str. 11, Lviv, 79019, Ukraine

    Mariana Rydchuk, Sophia Ivakh, Dmytro Yanovych, Zvenyslava Zasadna & Serhiy Plotycya

Authors
  1. Kateryna Plotnikova
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  2. Liliya Dubenska
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  3. Petro Rydchuk
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  4. Solomiya Pysarevska
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  5. Mariana Rydchuk
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  6. Sophia Ivakh
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  7. Dmytro Yanovych
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  8. Zvenyslava Zasadna
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  9. Serhiy Plotycya
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All authors contributed to the study conception and design. All authors read and approved the final manuscript.

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Correspondence to Sophia Ivakh.

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Plotnikova, K., Dubenska, L., Rydchuk, P. et al. Voltammetric determination of 5-nitroimidazole derivatives in honey and HPLC-MS/MS confirmation. Food Measure 16, 891–900 (2022). https://doi.org/10.1007/s11694-021-01214-z

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  • DOI: https://doi.org/10.1007/s11694-021-01214-z

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