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Phenolic profile, antioxidant and antiproliferative activities of diverse peanut cultivars

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Abstract

Many phenolic compounds serve as natural antioxidants by preventing food oxidation and oxidative stress in the body. In this study, antioxidant compounds were extracted from five peanut cultivars. Samples were evaluated for their total phenolic content, total flavonoid content, antioxidant activities using 2,2′-diphenyl-1-picrylhydrazyl radical (DPPH) assay and ferric reducing antioxidant power (FRAP) assay, antiproliferative activities against two colon cancer cell lines (HCT116 and HT29), and intracellular ROS generation. The peanuts rich in phenolics (185.4–300.9 mg GAE/100 g DW) and flavonoids (62.79–86.27 mg CE/100 g DW), and has relative good antioxidant capability (DPPH, 6.65–9.45 μmol Trolox/g DW and FRAP, 8.80–13.6 μmol Fe (II)/g DW). The peanut extracts exhibited strong antiproliferative effect against HCT116 and HT29 with IC50 value of 1.39–9.33 mg dry extract/ml and 1.56–7.55 mg dry extract/ml, respectively. The antiproliferative effects are partly due to the intracellular reactive oxygen species (ROS) generation. Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was used to characterize the phenolic profiles of peanut cultivar extract and 23 phenolic compounds were tentatively identified, most of which were flavonoids. Peanuts are rich in phenolic compounds and have antioxidant activity and antiproliferative activity, thus, it may serve as viable functional food ingredients with antioxidant potential.

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Acknowledgements

This study was funded by the Shanghai Basic and Key Program (18JC1410800) and the Shanghai Agricultural Science and Technology Key Program (18391900600).

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Authors and Affiliations

  1. Department of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China

    Qiong-Qiong Yang, Gowoon Kim, Arakkaveettil Kabeer Farha, Qiong Luo & Harold Corke

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  2. Gowoon Kim
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Correspondence to Harold Corke.

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Qiong-Qiong Yang declares that she has no conflict of interest, Gowoon Kim declares that she has no conflict of interest, Arakkaveettil Kabeer Farha declares that she has no conflict of interest, Qiong Luo declares that she has no conflict of interest, and Harold Corke declares that he has no conflict of interest.

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Yang, QQ., Kim, G., Farha, A.K. et al. Phenolic profile, antioxidant and antiproliferative activities of diverse peanut cultivars. Food Measure 14, 2361–2369 (2020). https://doi.org/10.1007/s11694-020-00483-4

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  • DOI: https://doi.org/10.1007/s11694-020-00483-4

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