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Implication du microbiote intestinal dans l’obésité et les pathologies associées : quelles perspectives thérapeutiques et nutritionnelles ?

Implication of the gut microbiota in obesity and metabolic disorders: focus on therapeutic and nutritional perspectives

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Obésité

Résumé

Les cent mille milliards de bactéries qui colonisent l’intestin interviennent dans la régulation du métabolisme énergétique et de fonctions biologiques importantes de l’hôte. Cet article résume les données récentes qui décrivent les changements de composition et d’activité bactériennes associées au surpoids et aux pathologies associées, en évaluant les approches expérimentales qui pourraient mener à la découverte de nouvelles cibles thérapeutiques (et nutritionnelles) dans le contexte de l’obésité.

Abstract

The gut microbiota is increasingly considered as a symbiotic partner for the maintenance of health. Experimental data in animals and observational studies in obese patients, describe differences in gut microbiota composition in obese and in lean individuals, or patients presenting obesity-related metabolic alterations. The metagenomic approaches could help discovering how the complex gut microbial ecosystem could participate in the control of host energy metabolism, and could be relevant for future therapeutic developments, including nutritional approaches, for overweight patients.

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Authors and Affiliations

  1. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, 73 av. E. Mounier, Boîte B1.73.11, B-1200, Bruxelles, Belgique

    N. M. Delzenne, A. M. Neyrinck & P. D. Cani

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  1. N. M. Delzenne
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  2. A. M. Neyrinck
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  3. P. D. Cani
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Correspondence to N. M. Delzenne.

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Delzenne, N.M., Neyrinck, A.M. & Cani, P.D. Implication du microbiote intestinal dans l’obésité et les pathologies associées : quelles perspectives thérapeutiques et nutritionnelles ?. Obes 7, 234–239 (2012). https://doi.org/10.1007/s11690-012-0346-5

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  • DOI: https://doi.org/10.1007/s11690-012-0346-5

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