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Organ function support in patients with coronavirus disease 2019: Tongji experience

Frontiers of Medicine volume 14, pages 232–248 (2020)Cite this article

Abstract

Coronavirus disease 2019 (COVID-19) is a highly contagious disease and a serious threat to human health. COVID-19 can cause multiple organ dysfunction, such as respiratory and circulatory failure, liver and kidney injury, disseminated intravascular coagulation, and thromboembolism, and even death. The World Health Organization reports that the mortality rate of severe-type COVID-19 is over 50%. Currently, the number of severe cases worldwide has increased rapidly, but the experience in the treatment of infected patients is still limited. Given the lack of specific antiviral drugs, multi-organ function support treatment is important for patients with COVID-19. To improve the cure rate and reduce the mortality of patients with severe- and critical-type COVID-19, this paper summarizes the experience of organ function support in patients with severe- and critical-type COVID-19 in Optical Valley Branch of Tongji Hospital, Wuhan, China. This paper systematically summarizes the procedures of functional support therapies for multiple organs and systems, including respiratory, circulatory, renal, hepatic, and hematological systems, among patients with severe- and critical-type COVID-19. This paper provides a clinical reference and a new strategy for the optimal treatment of COVID-19 worldwide.

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Authors and Affiliations

  1. Department of Respiratory and Critical Care Medicine, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Yong Li

  2. Department of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Fan He & Shuiming Guo

  3. Department of Cardiology, Department of Internal Medicine and Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Ning Zhou, Luyun Wang, Peng Chen & Xiaoning Wan

  4. Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Ning Zhou, Luyun Wang, Peng Chen & Xiaoning Wan

  5. Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Jia Wei

  6. Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Zeyang Ding & Binhao Zhang

  7. Hubei Key Laboratory of HPB Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Zeyang Ding & Binhao Zhang

  8. Department of Emergency and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Wei Zhu

Authors
  1. Yong Li
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  2. Fan He
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  3. Ning Zhou
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  4. Jia Wei
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  5. Zeyang Ding
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  6. Luyun Wang
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  7. Peng Chen
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  8. Shuiming Guo
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  9. Binhao Zhang
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  10. Xiaoning Wan
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  11. Wei Zhu
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Consortia

Multidisciplinary Team for COVID-19

Corresponding author

Correspondence to Wei Zhu.

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The authors declare that they have no conflicts of interest. This manuscript does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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Li, Y., He, F., Zhou, N. et al. Organ function support in patients with coronavirus disease 2019: Tongji experience. Front. Med. 14, 232–248 (2020). https://doi.org/10.1007/s11684-020-0774-9

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  • DOI: https://doi.org/10.1007/s11684-020-0774-9

Keywords

  • COVID-19
  • severe and critical type
  • organ function support