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Immunoregulatory effects of Tripterygium wilfordii Hook F and its extracts in clinical practice

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Abstract

Tripterygium wilfordii Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewed their effects for use in clinical practice. This review provides a comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinical studies. TwHF and its extracts affect the proliferation and activation of Tand B cells; ratio of Tcell subsets; inflammatory response of monocytes, macrophages, and immunoglobulins; and secretion of many cytokines. Together, these effects dictate immune function in a variety of diseases. TwHF and its extracts can be used alone or in combination with existing therapies against many immune disorders through immunomodulation.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 81673844, 81573845, 81373773, and 81760838), the Beijing Natural Science Foundation (No. 7142144), China Scholarship Council Fund (No. 201609110029), the International Cooperation Project of the State Administration of Traditional Chinese Medicine (No. GZYYGJ2017014), and the International Cooperation Project of the Ministry of Science and Technology (No. 2014DFA31490).

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Traditional Chinese Medicine Hospital of Changping District, Beijing, 102200, China

    Dan Luo

  2. Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, 100029, China

    Dan Luo & Cheng Xiao

  3. Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China

    Zhengyun Zuo

  4. Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100070, China

    Hongyan Zhao

  5. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100070, China

    Yong Tan

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  1. Dan Luo
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  2. Zhengyun Zuo
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  3. Hongyan Zhao
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  5. Cheng Xiao
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Correspondence to Cheng Xiao.

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Dan Luo, Zhengyun Zuo, Hongyan Zhao, Yong Tan, and Cheng Xiao declare that they have no financial conflicts of interest. This manuscript is a review article and does not involve a research protocol requiring approval by a relevant institutional review board or ethics committee.

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Luo, D., Zuo, Z., Zhao, H. et al. Immunoregulatory effects of Tripterygium wilfordii Hook F and its extracts in clinical practice. Front. Med. 13, 556–563 (2019). https://doi.org/10.1007/s11684-018-0649-5

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  • DOI: https://doi.org/10.1007/s11684-018-0649-5

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