Abstract
Tripterygium wilfordii Hook F has significant anti-inflammatory and immunosuppressive properties and is widely used for treating autoimmune and inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus, and kidney disease, especially in traditional Chinese medicine. The mechanisms underlying its effects may be diverse but they remain unclear, and its toxicity and side effects limit its wider clinical application. This review summarizes the clinical application of Tripterygium wilfordii Hook F in recent years, as well as the results of studies into its mechanisms and toxicity, to provide a reference for its future clinical application.
概 要
雷公藤作为中国传统药材的瑰宝, 具有较强的抗炎及免疫抑制作用, 临床上广泛应用于类风湿性关节炎、 系统性红斑狼疮、 肾脏疾病等自身免疫性及炎症性疾病. 由于雷公藤对于自身免疫疾病疗效显著, 且没有激素的副作用, 近年来备受国内外研究者关注, 大量研究开始探究其抗炎及免疫抑制的潜在机制. 而雷公藤本身也存在毒副作用, 限制了其在临床更广泛的应用. 本文总结了近年来雷公藤在免疫相关炎性疾病临床应用情况, 雷公藤抗炎和免疫调节的机制以及目前雷公藤减毒的方法, 旨在更好地帮助临床医生及科研工作者理解雷公藤的生物特性及作用机制, 为临床应用及推广提供参考依据.
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We thank Jiao-jiao YANG (the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China) for providing assistance with language editing.
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Cong-ying SONG and Yuan-qiang LU participated in the design. Cong-ying SONG and Ying-ge XU wrote this article. Yuan-qiang LU checked the final version. All authors have read and approved the final manuscript.
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Cong-ying SONG, Ying-ge XU, and Yuan-qiang LU declare that they have no conflict of interest.
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Project supported by the Foundation of Key Discipline Construction of Zhejiang Province for Traditional Chinese Medicine (No. 2017XK-A36), the Medical and Health Science Foundation of Zhejiang Province (No. 2019327552), the Foundation of Key Research Project of Zhejiang Province for Traditional Chinese Medicine (No. 2019ZZ014), and the Foundation of Science and Technology Department of Zhejiang Province for Beneficial Technology Research of Social Development (No. 2015C33146), China
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Song, Cy., Xu, Yg. & Lu, Yq. Use of Tripterygium wilfordii Hook F for immune-mediated inflammatory diseases: progress and future prospects. J. Zhejiang Univ. Sci. B 21, 280–290 (2020). https://doi.org/10.1631/jzus.B1900607
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DOI: https://doi.org/10.1631/jzus.B1900607