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Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

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Abstract

The relationship between the tenth exon C825T of G-protein β3 subunit (GNB3) genetic polymorphism and hypertension in the Uygur population of China was investigated. A nested case-control study (n = 738) was carried out. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to genotype GNB3 C825T polymorphism in 354 hypertensive (HT) and 384 normotensive (NT) Uygur subjects. The distributions of GNB3 C825T genotypes were CC (27.2%), TT (42.9%), and CT (29.9%) in the hypertensive subjects and CC (27.7%), TT (42.4%), CT (29.9%) in the normotensive subjects. There were no significant differences in the genotype distributions between the two groups (χ 2 = 0.0262 P = 0.99). The T allele was 51.4% in hypertensive subjects and 51.2% in normotensive subjects, which, between the two groups, was not a significant difference (χ 2 = 0.0016 P = 0.97). Further analysis shows that there is no association between C825T genotypes and age, body mass index (BMI), Glucose (GLU), Triglyceride (TG), Cholesterol (CHO), systolic blood pressure (SBP) and diastolic blood pressure (DBP). No evidence was found to suggest an association between GNB3 C825T polymorphism and hypertension in the Uygur population of China.

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Authors and Affiliations

  1. Department of Biology, School of Environment and Chemical Engineering, Luoyang University, Luoyang, 471000, China

    Jing Jianying BS

  2. Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, 200433, China

    Wang Dan BS, Wang Xiaofeng PhD, Jin Jianzhong MS & Jin Li PhD

  3. Department of Biochemical and Molecular Biology, Xinjiang Medical University, Urumqi, 830054, China

    Jiao Yi MS

  4. Central Laboratory, the First Affiliated Hospital, Xinjiang Medical University, Urumqi, 830054, China

    Wen Hao PhD & Lin Renyong PhD

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  1. Jing Jianying BS
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  2. Wang Dan BS
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  3. Jiao Yi MS
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  4. Wang Xiaofeng PhD
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  5. Wen Hao PhD
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  6. Lin Renyong PhD
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  7. Jin Jianzhong MS
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  8. Jin Li PhD
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Correspondence to Jing Jianying BS.

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Translated from Journal of Fudan University (Medical Sciences), 2006, 33(4): 433–436 [译自: 复旦大学学报 (医学版)]

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Jing, J., Wang, D., Jiao, Y. et al. Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group. Front. Med. China 1, 230–233 (2007). https://doi.org/10.1007/s11684-007-0045-z

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