Abstract
Hypertension has become a prominent public health concern. Essential hypertension (EH) is a polygenic disorder caused by multiple susceptibility genes. It has been previously shown that the purinergic P2Y2 receptor (P2Y2R) regulates blood pressure; however, whether P2Y2R genetic polymorphisms correlate with EH has not been investigated in Chinese. Our study included 500 EH cases and 504 controls who are Chinese postmenopausal women. We used allele-specific polymerase chain reaction (ASPCR) to genotype five single-nucleotide polymorphism (SNPs) in the P2Y2R gene, i.e., rs4944831, rs12366239, rs1783596, rs4382936, and rs10898909. We assessed the association of P2Y2R genetic polymorphisms with EH susceptibility. The results demonstrated that P2Y2R rs4382936A was correlated with a high risk of EH; particularly, the participants with the rs4382936A allele and CA/AA/(CA+AA) genotypes were at higher risks to EH compared to the subjects with the rs4382936C allele and CC genotype. Moreover, haplotype CAG combined by rs1783596-rs4382936-rs10898909 was a susceptible haplotype for EH, whereas haplotype CCG was a protective haplotype for EH. These results may provide new evidence for applying P2Y2R genetic polymorphisms as useful markers in clinic screening or monitoring potential EH cases in a population of Chinese postmenopausal women.
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The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.
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Funding
This work was supported by the National Natural Science Foundation of China (NOs. 81302501 and 82260639) and the “Double Thousand Plan” Science and Technology Innovation High-end Talent Project of Jiangxi Province.Recipient: Hong Xu.
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Hong Xu conceived and designed the experiments. Chengxin Gong, Chaopeng Xiong, and Yuping Yang collected the samples. Chengxin Gong, Yaqun Wang, and Mengyang Gou performed the experiments. Hong Xu and Ao Li analyzed the data, wrote and revised the paper. All authors critically reviewed and approved the manuscript.
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The study was approved by Ethnical Committee of Nanchang University (approval No. 2013-013).
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Li, A., Xiong, C., Gong, C. et al. Genetic polymorphisms of purinergic P2Y2 receptor were associated with the susceptibility to essential hypertension in Chinese postmenopausal women. Purinergic Signalling 19, 663–671 (2023). https://doi.org/10.1007/s11302-023-09921-6
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DOI: https://doi.org/10.1007/s11302-023-09921-6