Abstract
Previous studies have provided evidence of structural and functional changes in the brains of patients with tension-type headache (TTH). However, investigations of functional connectivity alterations in TTH have been inconclusive. The present study aimed to investigate abnormal intrinsic functional connectivity patterns in patients with TTH through the voxel-wise degree centrality (DC) method as well as functional connectivity (FC) analysis. A total of 33 patients with TTH and 30 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rs-fMRI) scanning and were enrolled in the final study. The voxel-wise DC method was performed to quantify abnormalities in the local functional connectivity hubs. Nodes with abnormal DC were used as seeds for further FC analysis to evaluate alterations in functional connectivity patterns. In addition, correlational analyses were performed between abnormal DC and FC values and clinical features. Compared with HCs, patients with TTH had higher DC values in the left middle temporal gyrus (MTG.L) and lower DC values in the left anterior cingulate and paracingulate gyri (ACG.L) (GRF, voxel-wise p < 0.05, cluster-wise p < 0.05, two-tailed). Seed-based FC analyses revealed that patients with TTH showed greater connections between ACG.L and the right cerebellum lobule IX (CR-IX.R), and smaller connections between ACG.L and ACG.L. The MTG.L showed increased FC with the ACG.L, and decreased FC with the right caudate nucleus (CAU.R) and left precuneus (PCUN.L) (GRF, voxel-wise p < 0.05, cluster-wise p < 0.05, two-tailed). Additionally, the DC value of the MTG.L was negatively correlated with the DASS-depression score (p = 0.046, r=-0.350). This preliminary study provides important insights into the pathophysiological mechanisms of TTH.
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Data availability
Raw data were generated at the Affiliated Hospital of Weifang Medical University. Derived data supporting the findings of this study are available from the corresponding author Xize Jia on request.
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References
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Acknowledgements
We would like to thank all patients and volunteers as well as research assistants for their participation in this study. We thank International Science Editing (http://www.internationalscienceediting.com) for editing this manuscript.
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This study was funded by National Natural Science Foundation of China (82001898), Natural Science Foundation of Shandong Province (ZR2017MH110, ZR2017MH037), Major Scientific and Technological Innovation Project of Shandong Province (2019TSLH0410), Taishan Scholars Project Special Fund (tsqn202306134), and Scientific Research Project Plan of Weifang Health Commission (WFWSJK-2023-349, WFWSJK-2023-037).
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Study concept and design: XZJ, XZW, XHS. Acquisition of data: JZS,CW, QYX, JLW. Analysis and interpretation of data: JJW，XXM and CLL.Drafting of the manuscript: SXZ. Revising it for intellectual content: MQZ, MTL. All authors read and approved the final manuscript.
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Zhang, S., Zhao, M., Sun, J. et al. Alterations in degree centrality and functional connectivity in tension-type headache: a resting-state fMRI study. Brain Imaging and Behavior (2024). https://doi.org/10.1007/s11682-024-00875-w
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DOI: https://doi.org/10.1007/s11682-024-00875-w