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Differences in small-world networks between methamphetamine and heroin use disorder patients and their relationship with psychiatric symptoms

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Abstract

Both methamphetamine use disorder (MAUD) and heroin use disorder (HUD) implicated in substance-induced psychosis, but the psychiatirc symptoms induced by MAUD and HUD are significantly different. The functional network organizations that may underlie these differences remains unknown. Image data was acquired by resting-state fMRI from 19 MAUD patients, 21 HUD patients, and 20 healthy controls. The small-world properties, node attributes, and functional connectivity of brain regions were analyzed among the three groups. Psychiatric status was evaluated by the Symptom Checklist 90 in all participants. The MAUD patients had significantly higher psychiatric scores than the controls and HUD patients. Both MAUD and HUD patients still had economical small-world properties. The MAUD patients showed increased nodal efficiency and betweenness centrality in the right inferior occipital gyrus, left insular lobe, bilateral Heschl gyrus, and bilateral superior temporal gyrus, while the node attributes decreased in the right parahippocampal gyrus and right hippocampus compared to the HUD patients. The MAUD patients also showed reduced edge connectivity between left dorsolateral prefrontal cortex (dlPFC) and left middle occipital gyrus (MOG), as well as between bilateral orbitofrontal cortex (OFC) and bilateral superior occipital gyrus (SOG), left MOG, or right cuneus. In the MAUD group, the functional connection between left dlPFC and left MOG was negatively correlated with depression, while the connection between right cuneus lobe and right OFC was negatively correlated with depression and interpersonal sensitivity. These brain regions related to cognitive, emotional, and auditory/visual regulation may play an important role in the psychiatric symptoms of MAUD.

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Acknowledgements

All authors made substantial contributions to this manuscript and take responsibility for its content. WL and WW was responsible for the study design. LW, YW, JC, JZ, YL and HS contributed to the acquisition of fMRI and demographical data. YL, QL and TZ performed the data analysis. WL and JC assisted with data analysis and interpretation of findings. YL drafted the manuscript. All authors critically reviewed content and approved final version for publication.

Funding

This work was supported by grants from the National Natural Science Foundation of China (Nos. 81771813, 81401393, and 81671661).

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  1. Yan Liu, Qiang Li and Tianyi Zhang contributed equally to this work.

Authors and Affiliations

  1. Department of Radiology, Tangdu Hospital, Air Force Medical University, 569 Xinsi Road, BaQiao District, Xi’an, 710038, Shaanxi, China

    Yan Liu, Qiang Li, Tianyi Zhang, Jiajie Chen, Jia Zhu, Wei Wang & Wei Li

  2. Department of Radiology, Xi’an Gem Flower Changqing Hospital, Xi’an, 710018, Shaanxi, China

    Yan Liu

  3. The Basic Medical College, Air Force Medical University, Xi’an, 710032, Shaanxi, China

    Tianyi Zhang

  4. Department of Nuclear Medicine, Tangdu Hospital, Air Force Medical University, Xi’an, 710038, Shaanxi, China

    Lei Wang

  5. Department of Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, Shaanxi, China

    Yarong Wang

  6. Xi’an No.1 Hospital, Xi’an, 710002, Shaanxi, China

    Hong Shi

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Liu, Y., Li, Q., Zhang, T. et al. Differences in small-world networks between methamphetamine and heroin use disorder patients and their relationship with psychiatric symptoms. Brain Imaging and Behavior 16, 1973–1982 (2022). https://doi.org/10.1007/s11682-022-00667-0

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