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Frontoinsular cortical microstructure is linked to life satisfaction in young adulthood

  • SI: Pacific Rim 2020
  • Published:
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Abstract

Life satisfaction is a component of subjective well-being that reflects a global judgement of the quality of life according to an individual’s own needs and expectations. As a psychological construct, it has attracted attention due to its relationship to mental health, resilience to stress, and other factors. Neuroimaging studies have identified neurobiological correlates of life satisfaction; however, they are limited to functional connectivity and gray matter morphometry. We explored features of gray matter microstructure obtained through compartmental modeling of multi-shell diffusion MRI data, and we examined cortical microstructure in frontoinsular cortex in a cohort of 807 typical young adults scanned as part of the Human Connectome Project. Our experiments identified the orientation dispersion index (ODI), and analogously fractional anisotropy (FA), of frontoinsular cortex as a robust set of anatomically-specific lateralized diffusion MRI microstructure features that are linked to life satisfaction, independent of other demographic, socioeconomic, and behavioral factors. We further validated our findings in a secondary test-retest dataset and found high reliability of our imaging metrics and reproducibility of outcomes. In our analysis of twin and non-twin siblings, we found basic microstructure in frontoinsular cortex to be strongly genetically determined. We also found a more moderate but still very significant genetic role in determining microstructure as it relates to life satisfaction in frontoinsular cortex. Our findings suggest a potential linkage between well-being and microscopic features of frontoinsular cortex, which may reflect cellular morphology and architecture and may more broadly implicate the integrity of the homeostatic processing performed by frontoinsular cortex as an important component of an individual’s judgements of life satisfaction.

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Availability of data and material

Data used in our study is available with permission from the Human Connectome Project Footnote 2. Our data image analysis and visualization tools available online as part of the Quantitative Imaging Toolkit (QIT) Footnote 3Footnote 4.

Notes

  1. https://www.healthmeasures.net/explore-measurement-systems/nih-toolbox/intro-to-nih-toolbox/emotion

  2. https://www.humanconnectome.org/study/hcp-young-adult/data-releases

  3. https://cabeen.io/qitwiki

  4. https://resource.loni.usc.edu/resources/downloads/

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Funding

This work was supported by National Institutes of Health (grant number P41EB015922) and made possible in part by grant number 2020-225670 from the Chan Zuckerberg Initiative DAF, an advised fund of Silicon Valley Community Foundation. Data were provided in part by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University.

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  1. Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA

    Ryan P. Cabeen & Arthur W. Toga

  2. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA

    John M. Allman

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  1. Ryan P. Cabeen
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Correspondence to Ryan P. Cabeen.

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Cabeen, R.P., Toga, A.W. & Allman, J.M. Frontoinsular cortical microstructure is linked to life satisfaction in young adulthood. Brain Imaging and Behavior 15, 2775–2789 (2021). https://doi.org/10.1007/s11682-021-00467-y

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