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Reliability and availability of granger causality density in localization of Rolandic focus in BECTS

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A Correction to this article was published on 10 November 2022

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Abstract

A new method, called granger causality density (GCD), could reflect the directed information flow of the epileptiform activity, which is much closely match with excitatory and inhibitory imbalance theory of epilepsy. Here, we investigated if GCD could effectively localize the Rolandic focus in 50 patients with benign childhood epilepsy with central-temporal spikes (BECTS) from 27 normal children. The BECTS were classified into ictal epileptiform discharges (IEDs; 12 females, 15 males;age, 8.15 ± 1.68 years) and non-IEDs (10 females, 13 males; age, 9.09 ± 1.98 years) subgroups depending on the presence of central-temporal spikes. Multiple correlation-modality analyses (Pearson, across-voxel and across-subject correlations) were used to calculate the couplings between the GCD maps and IEDs-related brain activation map. The individual lateralization coefficient of localize IEDs and multiple regression analysis were used to identify the reliability of the GCD method in localizing the Rolandic focus. In this study, multiple correlation-modality analyses showed that the IEDs-related brain activation map and the GCD maps had highly temporal (coefficient ׀r\= 0.56 ~ 0.65) and spatial (\r\=0.53~0.91) (r\=~ couplings. The proposed GCD method and multiple regression analyses showed consistent findings with the clinical EEG recordings in lateralization of Rolandic focus. Furthermore, the GCD method could reflect the epilepsy-related brain activity during non-IEDs substate. Therefore, the proposed GCD method has the potential to be served as an effective and reliable neuroimaging biomarker to localize the Rolandic focus of BECTS. These findings are critical for clinical early diagnosis, and may promote the progression of treatment and management of pediatric epilepsy.

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Acknowledgments

This work was supported by National Natural Science Foundation of China (grant No, 81701678) and Guangdong Basic and Applied Basic Research Foundation (2020A1515011469).

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  1. Shenzhen Mental Health Centre, Shenzhen Kangning Hospital, Shenzhen, 518003, China

    Xi-Jian Dai, Na Wang, Weiqun Tao, Jingyi Fan & Yongjun Wang

  2. Department of Radiology, the Affiliated Hospital of Zunyi Medical University, Medical Imaging Center of Guizhou Province, Zunyi, 563000, China

    Yang Yang

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Contributions

XJ.D., J. L., and Y. W. conceived and designed the whole experiment; XJ.D., Y. Y., N. W., W. T., and J. F. take responsibility for the integrity of the data, the accuracy of the data analysis and statistical data analysis; XJ.D. wrote the main manuscript text, and under took the critical interpretation of the data. All authors contributed to the final version of the paper and have read, as well as, approved the final manuscript.

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Supplementary Fig S1

Total-flow causal effective connectivity differences among the IEDs, non-IEDs and NCs group Abbreviations: IEDs, Ictal epileptiform discharges; L, left; R, right; NCs, Normal controls. (JPG 3706 kb)

Supplementary Fig S2

In-flow causal effective connectivity differences among the IEDs, non-IEDs and NCs group Abbreviations: IEDs, Ictal epileptiform discharges; L, left; R, right; NCs, Normal controls. (JPG 3750 kb)

Supplementary Fig S3

Out-flow causal effective connectivity differences among the IEDs, non-IEDs and NCs group Abbreviations: IEDs, Ictal epileptiform discharges; L, left; R, right; NCs, Normal controls. (JPG 3700 kb)

Supplementary Fig S4

Int-flow causal effective connectivity differences among the IEDs, non-IEDs and NCs group Abbreviations: IEDs, Ictal epileptiform discharges; L, left; R, right; NCs, Normal controls. (JPG 3742 kb)

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Dai, XJ., Yang, Y., Wang, N. et al. Reliability and availability of granger causality density in localization of Rolandic focus in BECTS. Brain Imaging and Behavior 15, 1542–1552 (2021). https://doi.org/10.1007/s11682-020-00352-0

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