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Right arcuate fasciculus and superior longitudinal fasciculus abnormalities in primary insomnia

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Abstract

Primary insomnia (PI) is a very common phenomenon and associated with functional impairments of attention, memory and mood regulation. However, its neurobiology is poorly understood. To date, the studies about integrity of white matter (WM) tracts in PI patients have been still rare. In the present study, we used Automated Fiber Quantification (AFQ), which reliably and efficiently quantified diffusion measurements at multiple locations along the WM trajectory based on diffusion tensor imaging (DTI), to assess WM diffusion properties differences between 23 PI patients and 32 matched healthy controls in 18 tracts. The relationships between neuroimaging differences and sleep behaviors were explored, including Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index Scale (ISI). Compared with healthy control group, right arcuate fasciculus (Arc) and superior longitudinal fasciculus (SLF) showed significant higher fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) along tract length in PI patients (FWE corrected, p < 0.01). Axial diffusivity (AD) for PI patients was higher in right Arc and lower in right SLF. Correlation analyses revealed that FA of right Arc and MD of right SLF were negatively correlated with PSQI score in PI patients, and AD of right Arc and FA of right SLF were positively correlated with PSQI score. Negative correlation was observed between FA of right Arc and AD of right SLF and ISI score in PI patients. Our findings can help us to improve the understanding of the neural mechanisms of primary insomnia at abnormalities in WM microstructure.

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Acknowledgements

This research was supported by the National Natural Science Foundation of China under Grant Nos. 81871426, 81871430, 81571751, 81571753, 61771266, 31800926, 8151650 and 81701780, the Fundamental Research Funds for the Central Universities under the Grant No. JB151204, the program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region NJYT-17-B11, the Natural Science Foundation of Inner Mongolia under Grant No. 2017MS(LH)0814, the program of Science and Technology in Universities of Inner Mongolia Autonomous Region NJZY17262, the Innovation Fund Project of Inner Mongolia University of Science and Technology No. 2015QNGG03, National Natural Science Foundation of Shaanxi Province under Grant no. 2018JM7075 and the US National Institutes of Health, Intramural Research program Y1AA3009. The authors declare no conflicts of interest.

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  1. School of Life Science and Technology, Xidian University, Xi’an, Shanxi, 710071, People’s Republic of China

    Wanye Cai, Meng Zhao, Jingjing Liu & Kai Yuan

  2. Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi’an, People’s Republic of China

    Wanye Cai, Meng Zhao, Jingjing Liu & Kai Yuan

  3. Department of Neurology, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010, People’s Republic of China

    Bo Liu

  4. Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010, People’s Republic of China

    Dahua Yu & Kai Yuan

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Cai, W., Zhao, M., Liu, J. et al. Right arcuate fasciculus and superior longitudinal fasciculus abnormalities in primary insomnia. Brain Imaging and Behavior 13, 1746–1755 (2019). https://doi.org/10.1007/s11682-019-00160-1

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