Brain Imaging and Behavior

, Volume 11, Issue 2, pp 591–610

Structural imaging of mild traumatic brain injury may not be enough: overview of functional and metabolic imaging of mild traumatic brain injury

  • Samuel S. Shin
  • James W. Bales
  • C. Edward Dixon
  • Misun Hwang
Review Article

DOI: 10.1007/s11682-017-9684-0

Cite this article as:
Shin, S.S., Bales, J.W., Edward Dixon, C. et al. Brain Imaging and Behavior (2017) 11: 591. doi:10.1007/s11682-017-9684-0


A majority of patients with traumatic brain injury (TBI) present as mild injury with no findings on conventional clinical imaging methods. Due to this difficulty of imaging assessment on mild TBI patients, there has been much emphasis on the development of diffusion imaging modalities such as diffusion tensor imaging (DTI). However, basic science research in TBI shows that many of the functional and metabolic abnormalities in TBI may be present even in the absence of structural damage. Moreover, structural damage may be present at a microscopic and molecular level that is not detectable by structural imaging modality. The use of functional and metabolic imaging modalities can provide information on pathological changes in mild TBI patients that may not be detected by structural imaging. Although there are various differences in protocols of positron emission tomography (PET), single photon emission computed tomography (SPECT), functional magnetic resonance imaging (fMRI), electroencephalography (EEG), and magnetoencephalography (MEG) methods, these may be important modalities to be used in conjunction with structural imaging in the future in order to detect and understand the pathophysiology of mild TBI. In this review, studies of mild TBI patients using these modalities that detect functional and metabolic state of the brain are discussed. Each modality’s advantages and disadvantages are compared, and potential future applications of using combined modalities are explored.


Mild traumatic brain injury TBI Concussion Imaging Diffusion tensor imaging; DTI 

Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Samuel S. Shin
    • 1
  • James W. Bales
    • 2
  • C. Edward Dixon
    • 3
  • Misun Hwang
    • 4
  1. 1.Department of MedicineThe Johns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of Neurological SurgeryUniversity of Washington School of MedicineSeattleUSA
  3. 3.Department of NeurosurgeryUniversity of Pittsburgh School of MedicinePittsburghUSA
  4. 4.Russel H. Morgan Department of Radiology and Radiological ScienceThe Johns Hopkins University School of MedicineBaltimoreUSA

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