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Posterior cortical atrophy and Alzheimer’s disease: a meta-analytic review of neuropsychological and brain morphometry studies

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Abstract

This paper presents the first systematic review and meta-analysis of neuropsychological and brain morphometry studies comparing posterior cortical atrophy (PCA) to typical Alzheimer’s disease (tAD). Literature searches were conducted for brain morphometry and neuropsychological studies including a PCA and a tAD group. Compared to healthy controls (HC), PCA patients exhibited significant decreases in temporal, occipital and parietal gray matter (GM) volumes, whereas tAD patients showed extensive left temporal atrophy. Compared to tAD patients, participants with PCA showed greater GM volume reduction in the right occipital gyrus extending to the posterior lobule. In addition, PCA patients showed less GM volume loss in the left parahippocampal gyrus and left hippocampus than tAD patients. PCA patients exhibit significantly greater impairment in Immediate Visuospatial Memory as well as Visuoperceptual and Visuospatial Abilities than patients with tAD. However, tAD patients showed greater impairment in Delayed Auditory/Verbal Memory than patients with PCA. PCA is characterized by significant atrophy of the occipital and parietal regions and severe impairments in visuospatial functioning.

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References

  • Amieva, H., Phillips, L. H., Della Sala, S., & Henry, J. D. (2004). Inhibitory functioning in Alzheimer’s disease. Brain, 127(5), 949–964. doi:10.1093/brain/awh045.

    Article  PubMed  Google Scholar 

  • Aresi, A., & Giovagnoli, A. R. (2009). The role of neuropsychology in distinguishing the posterior cortical atrophy syndrome and Alzheimer’s disease. Journal of Alzheimer’s Disease, 18(1), 65–70. doi:10.3233/JAD-2009-1123.

    PubMed  Google Scholar 

  • Ashburner, J., & Friston, K. J. (2000). Voxel-based morphometry—the methods. Neuroimage, 11(6), 805–821. doi:10.1006/nimg.2000.0582.

    Article  PubMed  CAS  Google Scholar 

  • Backman, L., Jones, S., Berger, A. K., Laukka, E. J., & Small, B. J. (2004). Multiple cognitive deficits during the transition to Alzheimer’s disease. Journal of Internal Medicine, 256(3), 195–204. doi:10.1111/j.1365-2796.2004.01386.x.

    Article  PubMed  CAS  Google Scholar 

  • Benson, F., Davis, J., & Snyder, B. D. (1988). Posterior cortical atrophy. Archives of Neurology, 45, 789–793.

    Article  PubMed  CAS  Google Scholar 

  • Braak, H., & Braak, E. (1991). Neuropathological stageing of Alzheimer-related changes. Acta Neuropathologica, 82(4), 239–259.

    Article  PubMed  CAS  Google Scholar 

  • Caprile, C., Bosch, B., Rami, L., Sanchez-Valle Diaz, R., Bartres-Faz, D., & Molinuevo, J. L. (2009). Posterior cortical atrophy. Its neuropsychological profile and differences from typical Alzheimer’s disease. Revista de Neurologia, 48(4), 178–182.

    PubMed  CAS  Google Scholar 

  • Charles, R. F., & Hillis, A. E. (2005). Posterior cortical atrophy: clinical presentation and cognitive deficits compared to Alzheimer’s disease. Behavioural Neurology, 16(1), 15–23.

    PubMed  Google Scholar 

  • Clare, L., Woods, R. T., Moniz Cook, E. D., Orrell, M., & Spector, A. (2003). Cognitive rehabilitation and cognitive training for early-stage Alzheimer’s disease and vascular dementia. Cochrane Database of Systematic Reviews (4), CD003260. doi:10.1002/14651858.CD003260

  • Croisile, B. (2004). Benson’s syndrome or Posterior Cortical Atrophy. Orphanet Encyclopedia. http://www.orpha.net/data/patho/GB/uk-Benson.pdf. Accessed 30 September 2012.

  • Croisile, B., Astier, J. L., Beaumont, C., & Mollion, H. (2010). Validation of the Rapid BAttery of Denomination (BARD) in 382 controls and 1004 patients of a memory clinic. Revue Neurologique (Paris), 166(6–7), 584–593. doi:10.1016/j.neurol.2010.01.017.

    Article  CAS  Google Scholar 

  • Crutch, S. J., Lehmann, M., Schott, J. M., Rabinovici, G. D., Rossor, M. N., & Fox, N. C. (2012). Posterior cortical atrophy. Lancet Neurology, 11(2), 170–178. doi:10.1016/S1474-4422(11)70289-7.

    Article  PubMed  Google Scholar 

  • de Souza, L. C., Corlier, F., Habert, M. O., Uspenskaya, O., Maroy, R., Lamari, F., et al. (2011). Similar amyloid-beta burden in posterior cortical atrophy and Alzheimer’s disease. Brain, 134(7), 2036–2043. doi:10.1093/brain/awr130.

    Article  PubMed  Google Scholar 

  • DerSimonian, R., & Laird, N. (1986). Meta-analysis in clinical trials. Controlled Clinical Trials, 7(3), 177–188. doi:10.1016/0197-2456(86)90046-2.

    Article  PubMed  CAS  Google Scholar 

  • Feldmann, A., Trauninger, A., Toth, L., Kotek, G., Kosztolanyi, P., Illes, E., et al. (2008). Atrophy and decreased activation of fronto-parietal attention areas contribute to higher visual dysfunction in posterior cortical atrophy. Psychiatry Research, 164(2), 178–184. doi:10.1016/j.pscychresns.2008.01.006.

    Article  PubMed  Google Scholar 

  • Formaglio, M., Costes, N., Seguin, J., Tholance, Y., Le Bars, D., Roullet-Solignac, I., et al. (2011). In vivo demonstration of amyloid burden in posterior cortical atrophy: a case series with PET and CSF findings. Journal of Neurology, 258(10), 1841–1851. doi:10.1007/s00415-011-6030-0.

    Article  PubMed  Google Scholar 

  • Galton, C. J., Patterson, K., Xuereb, J. H., & Hodges, J. R. (2000). Atypical and typical presentations of Alzheimer’s disease: a clinical, neuropsychological, neuroimaging and pathological study of 13 cases. Brain, 123(3), 484–498.

    Article  PubMed  Google Scholar 

  • Josephs, K. A., Whitwell, J. L., Boeve, B. F., Knopman, D. S., Tang-Wai, D. F., Drubach, D. A., et al. (2006). Visual hallucinations in posterior cortical atrophy. Archives of Neurology, 63(10), 1427–1432. doi:10.1001/archneur.63.10.1427.

    Article  PubMed  Google Scholar 

  • Kas, A., de Souza, L. C., Samri, D., Bartolomeo, P., Lacomblez, L., Kalafat, M., et al. (2011). Neural correlates of cognitive impairment in posterior cortical atrophy. Brain, 134(5), 1464–1478. doi:10.1093/brain/awr055.

    Article  PubMed  Google Scholar 

  • Lehmann, M., Crutch, S. J., Ridgway, G. R., Ridha, B. H., Barnes, J., Warrington, E. K., et al. (2011). Cortical thickness and voxel-based morphometry in posterior cortical atrophy and typical Alzheimer’s disease. Neurobiology of Aging, 32(8), 1466–1476. doi:10.1016/j.neurobiolaging.2009.08.017.

    Article  PubMed  Google Scholar 

  • Lehmann, M., Barnes, J., Ridgway, G. R., Ryan, N. S., Warrington, E. K., Crutch, S. J., et al. (2012). Global gray matter changes in posterior cortical atrophy: a serial imaging study. Alzheimer’s & Dementia, 8(6), 502–512. doi:10.1016/j.jalz.2011.09.225.

    Article  Google Scholar 

  • McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology, 34(7), 939–944.

    Article  PubMed  CAS  Google Scholar 

  • McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Jr., Kawas, C. H., et al. (2011). The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s & Dementia, 7(3), 263–269. doi:10.1016/j.jalz.2011.03.005.

    Article  Google Scholar 

  • McMonagle, P., Deering, F., Berliner, Y., & Kertesz, A. (2006). The cognitive profile of posterior cortical atrophy. Neurology, 66(3), 331–338. doi:10.1212/01.wnl.0000196477.78548.db.

    Article  PubMed  Google Scholar 

  • Migliaccio, R., Agosta, F., Rascovsky, K., Karydas, A., Bonasera, S., Rabinovici, G. D., et al. (2009). Clinical syndromes associated with posterior atrophy: early age at onset AD spectrum. Neurology, 73(19), 1571–1578. doi:10.1212/WNL.0b013e3181c0d427.

    Article  PubMed  CAS  Google Scholar 

  • Migliaccio, R., Agosta, F., Possin, K. L., Rabinovici, G. D., Miller, B. L., & Gorno-Tempini, M. L. (2012a). White matter atrophy in Alzheimer’s disease variants. Alzheimer’s & Dementia, 8(5 Suppl), S78–S87. doi:10.1016/j.jalz.2012.04.010. e71–72.

    Article  Google Scholar 

  • Migliaccio, R., Agosta, F., Toba, M. N., Samri, D., Corlier, F., de Souza, L. C., et al. (2012b). Brain networks in posterior cortical atrophy: a single case tractography study and literature review. Cortex, 48(10), 1298–1309. doi:10.1016/j.cortex.2011.10.002.

    Article  PubMed  Google Scholar 

  • Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Medicine, 6(7), e1000097. doi:10.1371/journal.pmed.1000097.

    Article  PubMed  Google Scholar 

  • Nestor, P. J., Caine, D., Fryer, T. D., Clarke, J., & Hodges, J. R. (2003). The topography of metabolic deficits in posterior cortical atrophy (the visual variant of Alzheimer’s disease) with FDG-PET. Journal of Neurology, Neurosurgery & Psychiatry, 74(11), 1521–1529. doi:10.1136/jnnp.74.11.1521.

    Article  CAS  Google Scholar 

  • Radua, J., & Mataix-Cols, D. (2012). Meta-analytic methods for neuroimaging data explained. Biology of Mood & Anxiety Disorders, 2(1), 6. doi:10.1186/2045-5380-2-6.

    Article  Google Scholar 

  • Radua, J., Mataix-Cols, D., Phillips, M. L., El-Hage, W., Kronhaus, D. M., Cardoner, N., et al. (2012). A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps. Eur Psychiatry, 27(8), 605–611. doi:10.1016/j.eurpsy.2011.04.001.

    Article  PubMed  CAS  Google Scholar 

  • Scahill, R. I., Schott, J. M., Stevens, J. M., Rossor, M. N., & Fox, N. C. (2002). Mapping the evolution of regional atrophy in Alzheimer’s disease: unbiased analysis of fluid-registered serial MRI. Proceedings of the National Academy of Sciences of the United States of America, 99(7), 4703–4707. doi:10.1073/pnas.052587399.

    Article  PubMed  CAS  Google Scholar 

  • Shankar, G. M., & Walsh, D. M. (2009). Alzheimer’s disease: synaptic dysfunction and Abeta. Molecular Neurodegeneration, 4, 48. doi:10.1186/1750-1326-4-48.

    Article  PubMed  Google Scholar 

  • Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., et al. (1991). Physical basis of cognitive alterations in Alzheimer’s disease: synapse loss is the major correlate of cognitive impairment. Annals of Neurology, 30(4), 572–580. doi:10.1002/ana.410300410.

    Article  PubMed  CAS  Google Scholar 

  • Victoroff, J., Ross, G. W., Benson, D. F., Verity, M. A., & Vinters, H. V. (1994). Posterior cortical atrophy. Neuropathologic correlations. Archives of Neurology, 51(3), 269–274.

    Article  PubMed  CAS  Google Scholar 

  • Wallace, B. C., Schmid, C. H., Lau, J., & Trikalinos, T. A. (2009). Meta-Analyst: software for meta-analysis of binary, continuous and diagnostic data. BMC Medical Research Methodology, 9, 80. doi:10.1186/1471-2288-9-80.

    Article  PubMed  Google Scholar 

  • Westman, E., Cavallin, L., Muehlboeck, J. S., Zhang, Y., Mecocci, P., Vellas, B., et al. (2011). Sensitivity and specificity of medial temporal lobe visual ratings and multivariate regional MRI classification in Alzheimer’s disease. PLoS One, 6(7), e22506. doi:10.1371/journal.pone.0022506.

    Article  PubMed  CAS  Google Scholar 

  • Whitwell, J. L., Jack, C. R., Jr., Kantarci, K., Weigand, S. D., Boeve, B. F., Knopman, D. S., et al. (2007). Imaging correlates of posterior cortical atrophy. Neurobiology of Aging, 28(7), 1051–1061. doi:10.1016/j.neurobiolaging.2006.05.026.

    Article  PubMed  Google Scholar 

  • Yamasaki, T., Muranaka, H., Kaseda, Y., Mimori, Y., & Tobimatsu, S. (2012). Understanding the pathophysiology of Alzheimer’s disease and mild cognitive impairment: a mini review on fMRI and ERP studies. Neurology Research International, 2012, 719056. doi:10.1155/2012/719056.

    Article  PubMed  Google Scholar 

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Acknowledgments

JA is funded by a doctoral grant from the Foundation for Science and Technology, FCT (SFRH/BD/64457/2009, co-funded by FSE/POPH). JA and AS are funded by project PIC/IC/83290/2007, which is supported by FEDER (POFC—COMPETE) and FCT. JMS is supported by a fellowship of the project SwitchBox-FP7-HEALTH-2010-grant 259772-2. These organizations had no role in the study design, data collection, analysis, interpretation, or in the decision to submit the paper for publication.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Neuropsychophysiology Lab, CIPsi, School of Psychology, University of Minho, 4710-057, Braga, Portugal

    Jorge Alves, Adriana Sampaio & Óscar F. Gonçalves

  2. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, 4710-057, Braga, Portugal

    José Miguel Soares

  3. ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal

    José Miguel Soares

  4. Laboratório de Neuropsicofisiologia, Escola de Psicologia, Universidade do Minho, Campus de Gualtar, 4710-057, Braga, Portugal

    Jorge Alves

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  1. Jorge Alves
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  4. Óscar F. Gonçalves
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Correspondence to Jorge Alves.

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Alves, J., Soares, J.M., Sampaio, A. et al. Posterior cortical atrophy and Alzheimer’s disease: a meta-analytic review of neuropsychological and brain morphometry studies. Brain Imaging and Behavior 7, 353–361 (2013). https://doi.org/10.1007/s11682-013-9236-1

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