Abstract
Objective
To study the expression of Rho-GDP dissociation inhibitor β, γ (Rho-GDIβ, Rho-GDIγ) in lung squamous cell carcinoma and adenocarcinoma and its relationship with the expression of RhoC (Ras homologus oncogenes C) and clinicopathologic parameters.
Methods
Western blot assay was employed for Rho-GDIβ, Rho-GDIγ and RhoC in lung squamous cell carcinoma and adenocarcinoma and non-neoplastic lung tissues of 37 cases with fresh specimens.
Results
The study showed that Rho-GDIβ, Rho-GDIγ and RhoC were expressed in lung cancer and non-neoplastic lung tissues, the level in lung cancer tissue was much higher than that in non-neoplastic tissues (P<0.001). In lung cancer, the expression of Rho-GDIβ was much higher in patients with lymph node metastasis (P=0.021), and the expression of Rho-GDIγ was much higher in poorly differentiated tumor than in well-differentiated and moderately differentiated tumor, but both of them were not correlated with other clinicopathologic parameters. The expressions of Rho-GDIβ and Rho-GDIγ were not correlated with the expression of RhoC.
Conclusion
In lung cancer, Rho-GDIβ and Rho-GDIγ may play a role in the tumorigenesis, Rho-GDIβ may promote metastasis, and Rho-GDIγ may have some relationship with differentiation.
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This work was supported by the Natural Sciences Foundation of LiaoNing province in 2005(No. 20052085)
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Sun, Mn., Li, Xq., Jing-yi, Z. et al. Significance of the expression of Rho-GDP dissociation inhibitorβ,γ in lung squamous cell carcinoma and adenocarcinoma. Chin. J. Cancer Res. 19, 287–290 (2007). https://doi.org/10.1007/s11670-007-0287-y
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DOI: https://doi.org/10.1007/s11670-007-0287-y