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Expression of IL-13Ra2 gene in human brain tumors

  • Published:
Chinese Journal of Cancer Research

Abstract

Objective: To investigate the expression of IL-13Ra2 gene in brain tumors. Methods: Seventy-nine human brain tumors were obtained from the department of Neurosurgery of China Medical University. Human IL-13Ra2 expression was evaluated by reverse transcriptase polymerase chain reaction and immunohistochemical analysis. Results: IL-13Ra2 gene was highly expressed in glioblastoma, medulloblastoma, malignant meningioma and benign meningioma. Conclusion: Human IL-13Ra2 gene is expressed in brain tumors in addition to gliomas, and our result indicates that the IL-13Ra2 gene promoter based gene therapy method can be used to treat brain tumors in addition to gliomas. Further studies involving larger numbers of samples are necessary to fully understand the expression profile of IL-13Ra2 gene in the brain tumors.

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Authors and Affiliations

  1. Departments of Neurosurgery, The First Affiliated Hospital, China Medical University, 110001, Shenyang

    Wu An-hua, Tie Xin-xin, Wang Yun-jie & Yang Guo-rui

Authors
  1. Wu An-hua
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  2. Tie Xin-xin
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  3. Wang Yun-jie
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  4. Yang Guo-rui
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Corresponding author

Correspondence to Wu An-hua.

Additional information

Foundation item: This work was supported by National Natural Science Foundation of China (No.303000100) and HYD Educational Foundation (No. 94018).

Biography: WU An-hua (1970–), male, associate professor, The China Medical University, majors in immunotherapy and gene therapy of cancer.

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Wu, Ah., Tie, Xx., Wang, Yj. et al. Expression of IL-13Ra2 gene in human brain tumors. Chin. J. Cancer Res. 17, 157–160 (2005). https://doi.org/10.1007/s11670-005-0033-2

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  • DOI: https://doi.org/10.1007/s11670-005-0033-2

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