Abstract
Objective: To explore whether methylation of the CpG island in the promoter of the p16 tumor suppressor gene was associated with clinicopathological characteristics of the colorectal cancer patients. Methods: Methylation-specific PCR (MSP) was used to detect p16 methylation of the colorectal cancer patients. Results: In 58 sporadic colorectal cancer, 43.1% of the tumors had detectable p16 methylation. Dukes’ stage was associated with p16 methylation status. Dukes C, D patients (75%) were more likely to contain methylated p16 compared with Dukes A, B patients (13.3%). Conclusion: p16 methylation plays a role in the carcinogenesis of a subset of colorectal cancer. P16 methylation might be considered as a prognostic indicator.
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Foundation item: This work was supported by a grant from Ministry of Public Health of China (No. 98-1-303) and The Education Committee of Shanghai(No. 1 2000B02).
Biography: WANG Zhi-wei(1970–), master of medicine, Department of Cell Biology, Shanghai Second Medical University, majors in cell biology of cancer.
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Wang, Zw., Yi, J., Cang, H. et al. P16 methylation of the colorectal cancer and association with dukes stages. Chin. J. Cancer Res. 13, 288–290 (2001). https://doi.org/10.1007/s11670-001-0050-8
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DOI: https://doi.org/10.1007/s11670-001-0050-8