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The expression of receptors for vasoactive intestinal peptide and secretin in colon neoplasms

  • Clinical Observation
  • Published:
Chinese Journal of Cancer Research

Abstract

Objective: To investigate the expression of the receptors for vasoactive intestinal peptide (VIP) and secretin in colon cancer. Methods: This study visualized and characterized the receptors for VIP and secretin in the sequence of human tumor-free colon, adenoma, carcinoma, liver metastasis using storage phosphor autoradiography. Results: Receptors for VIP and secretin were demonstrated in tumor-free colon and colon tumors. A decrease in affinity of VIP receptors was shown in the colonic liver metastasis (Kd = 3.30 nmol) when compared with tumor-free colon (Kd = 0.82 nmol). An up-regulation of receptors for secretin was found in colonic liver metastases. Conclusions: VIP and secretin were both expressed on normal colon tissues. Binding of VIP decreased while secretin increased in colonic liver metastasis. A down-regulation of receptors for VIP in colonic liver metastases may helpful to understand the migration of colon cancer.

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Authors and Affiliations

  1. Department of Gastroenterology, The First Hospital, Chongqing University of Medical Sciences, 400016, Chongqing, China

    Tang Cheng-wei

  2. Dept of Gastroenterology - Hepatology, Leiden University Medical Center, Leiden, The Netherlands

    Izäk Biemond, Hein W Verspaget & Cornelis BHW Lamers

Authors
  1. Tang Cheng-wei
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  2. Izäk Biemond
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  3. Hein W Verspaget
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  4. Cornelis BHW Lamers
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Corresponding author

Correspondence to Tang Cheng-wei.

Additional information

Foundation item: This work was supported by a Grant from Chinese National Science Research Foundation of China for the Excellent Young Scientist(No. 39725012).

Biography: Tang cheng-wei, (1957–), doctor of medicine, professor, First Hospital, Chongqing University of Medical Sciences, majors in gastroenterological cancer.

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Tang, Cw., Biemond, I., Verspaget, H.W. et al. The expression of receptors for vasoactive intestinal peptide and secretin in colon neoplasms. Chin. J. Cancer Res. 13, 280–283 (2001). https://doi.org/10.1007/s11670-001-0048-2

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  • DOI: https://doi.org/10.1007/s11670-001-0048-2

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